eotaxin
- Known as:
- eotaxin
- Catalog number:
- Y214033
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- eotaxin
Related genes to: eotaxin
- Gene:
- CCL11 NIH gene
- Name:
- C-C motif chemokine ligand 11
- Previous symbol:
- SCYA11
- Synonyms:
- eotaxin, MGC22554
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-24
- Date modifiied:
- 2016-10-05
- Gene:
- CCL24 NIH gene
- Name:
- C-C motif chemokine ligand 24
- Previous symbol:
- SCYA24
- Synonyms:
- Ckb-6, MPIF-2, eotaxin-2, MPIF2
- Chromosome:
- 7q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-14
- Date modifiied:
- 2016-03-01
- Gene:
- CCL26 NIH gene
- Name:
- C-C motif chemokine ligand 26
- Previous symbol:
- SCYA26
- Synonyms:
- MIP-4alpha, eotaxin-3, IMAC, MIP-4a, TSC-1
- Chromosome:
- 7q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1999-06-09
- Date modifiied:
- 2016-10-05
Related products to: eotaxin
Related articles to: eotaxin
- Two distinct blood eosinophil subtypes have recently been described as inflammatory-like (iEOS-like) and resident-like (rEOS-like) eosinophils. Eosinophilopoietins - interleukin (IL)-3, IL-5, and GM-CSF, as well as C-C chemokines - CCL11, CCL24, and CCL26 (eotaxin-1, 2, 3), CCL5 (RANTES), are key regulators of eosinophil activity. However, our understanding of the effects of these cytokines on blood eosinophil subtype chemotaxis, adhesion, and reactive oxygen species (ROS) production in asthma is limited. - Source: PubMed
Publication date: 2025/11/19
Rimkunas AiridasJanuskevicius AndriusVasyle EgleKalinauskaite-Zukauske VirginijaPalacionyte JolitaMiliauskas SkaidriusMalakauskas Kestutis - MicroRNAs (miRNAs) have emerged as critical epigenetic regulators in the pathogenesis of childhood bronchial asthma. This study employed high-throughput sequencing to explore miRNA expression profiles in an asthma cohort, with a focus on elucidating the functional mechanisms of key miRNAs. Notably, among the miRNAs validated by RT-qPCR, miR-31-5p exhibited the largest area under the curve (AUC) value and demonstrated significant anti-inflammatory effects in an OVA-induced allergic inflammation mouse model. Bioinformatics analysis and dual-luciferase reporter assays confirmed that TBXA2R is a direct target of miR-31-5p. Mechanistically, stimulation with house dust mite (HDM) and IL-4 downregulated miR-31-5p expression in A549 cells, accompanied by elevated levels of TBXA2R and eotaxins (CCL11, CCL24, CCL26). Conversely, overexpression of miR-31-5p suppressed TBXA2R-mediated eotaxin production. These findings highlight the significant role of miR-31-5p in peripheral blood mononuclear cells (PBMCs) of asthmatic children, suggesting its potential involvement in upregulating eotaxin expression in A549 cells through negative regulation of TBXA2R. - Source: PubMed
Publication date: 2025/10/31
Luo WenweiLi GangZhou LutingWang TingChen JiaweiDong HetingHuang LiZhu CanhongYan YongdongZhang LiwenWan YuChen Zhengrong - A deeper understanding of the immune-based pathogenesis of alopecia areata is essential for the development of novel targeted therapies. Compared to cytokines, chemokines exhibit substantially higher serum concentrations, offering a more robust approach for large-scale immune profiling. However, the complexity of chemokine interactions presents challenges in defining their precise roles in AA. To explore these dynamics, we conducted a scoping review and meta-analysis of 46 original research articles examining chemokine expression in skin and blood samples from AA patients; meta-analysis was performed when three or more studies assessed the same chemokine in comparable groups. Th1-associated chemokines-including CXCL9, CXCL10, CCL5, and CXCL11-were consistently elevated in AA, reflecting the known IFN-γ-driven response. A distinct Th2 chemokine signature was also observed, with increased levels of CCL13, CCL17, CCL22, and CX3CL1. Additionally, elevated levels of CCL2, CCL3, CCL4 (monocyte/dendritic cell recruitment), and CCL11, CCL24, and CCL26 (eosinophil recruitment) suggest the involvement of immune pathways beyond classical T helper subsets. Meta-analysis confirmed significantly elevated serum levels of CXCL9 (p = 0.003), CXCL10 (p = 0.004), CXCL8 (p < 0.001), and CCL17 (p < 0.001). These findings reveal a complex chemokine profile in AA, dominated by Th1 activity but also implicating Th2 and other immune pathways, highlighting the potential benefit of broader immunomodulatory strategies to address the multifaceted immune dysregulation underlying the disease. - Source: PubMed
Publication date: 2025/09/03
Van Caelenberg EliseBelpaire Arnovan Geel NanjaSpeeckaert Reinhart - Molecular signatures of chronic rhinosinusitis with nasal polyps (CRSwNP) related to macrophages remain unclear. This study aimed to develop a macrophage-associated diagnostic signature for CRSwNP. - Source: PubMed
Wang EnhaoHao YangheSong JingYuan JingHong YuLi YingWang YangWang ChengshuoWang MingZhang Luo - To determine the inflammatory profile of CRSwNP in Brazil and characterize the subgroups of CRSwNP patients in this population through cluster analysis. - Source: PubMed
Publication date: 2024/08/01
Romano Fabrizio RValera Fabiana C PFornazieri Marco ALopes Natália M DMiyake Marcel MDolci Ricardo L LNakanishi MarcioFreire Gustavo S MSakano EuláliaToro Mariana D CKosugi Eduardo MGregorio Luciano LDos Santos Marco C JMurata JulianaFernandes Atilio MMoras Luis LAvelino Melissa A GCamargo Leandro ALessa Marcus MAlmeida Laiana do CRoithmann RenatoRedeker NicoleTepedino Miguel SVianna Pedro MPiltcher Otávio BMeotti Camila DBezerra Thiago F PVoegels Richard Lde Mendonça Pilan Renata RBatista Murashima Adriana de Ada Silva Lilian E C MArruda EuricoGarcia Denny MTamashiro EdwinAnselmo-Lima Wilma