SUR1 _ ABCC8
- Known as:
- SUR1 _ ABCC8
- Catalog number:
- Y214022
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- SUR1 _ ABCC8
Related genes to: SUR1 _ ABCC8
- Gene:
- ABCC8 NIH gene
- Name:
- ATP binding cassette subfamily C member 8
- Previous symbol:
- SUR, HRINS
- Synonyms:
- HI, PHHI, SUR1, MRP8, ABC36, HHF1, TNDM2
- Chromosome:
- 11p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-01-10
- Date modifiied:
- 2019-04-23
Related products to: SUR1 _ ABCC8
Related articles to: SUR1 _ ABCC8
- Oligogenic inheritance in maturity-onset diabetes of the young (MODY) remains poorly characterized, and the contribution of multiple candidate variants to disease pathogenesis is incompletely understood. - Source: PubMed
Publication date: 2026/04/23
Honda MakieHonda RyoNomura Teiko KomoriNishikado YuichiTakahashi YoshihiroHosomichi KazuyoshiTsunekawa ShinYabe DaisukeHorikawa Yukio - Genetic variants causing loss of function (LOF) of glucokinase or ATP-sensitive potassium (KATP) channels underlie diabetes or congenital hyperinsulinism, respectively, but how the co-occurrence of such variants affects glucose control is unknown. This study presents genotypes and clinical phenotypes in a pedigree with LOF variants in both GCK and the pancreatic KATP channel. Heterozygous glucokinase deletion masked infantile hyperinsulinemia and hypoglycemia caused by a heterozygous LOF KATP channel variant. Carriers of the LOF KATP variant exhibited a shift from hypoglycemia to diabetes, as has been reported previously in some carriers of KATP LOF variants. - Source: PubMed
Publication date: 2026/04/17
Saint-Martin CécileElSheikh AssmaaJacqueminet SophieArnoux Jean-BaptisteCiangura CécileBellanné-Chantelot ChristineShyng Show-Ling - Adenosine triphosphate (ATP)-sensitive potassium cardiac channels (K) are composed of inward rectifying potassium channel (Kir) subunit Kir6.1 or Kir6.2, encoded by KCNJ8 or KCNJ11, and the sulfonylurea receptor SUR2 or SUR1, encoded by ABCC9 or ABCC8. - Source: PubMed
Publication date: 2026/04/16
Hu DanHuang YanRangel-Sandoval CinthiaSánchez-Pastor EnriqueOnetti Carlos GFerrer-Villada TaniaJiang Meng-NanHasdemir CanAkin IbrahimZhou Xiao-BoEl-Battrawy IbrahimCui MengRomano JohnPinheiro MariahAcuña-Ochoa Jose GChen LiangZhuang Le-NanHao Guo-LiangZhan Li-YingJiang HongAntzelevitch CharlesBarajas-Martínez Hector - Proteinuria is a common manifestation of glomerular disease. Advances in genetic testing have improved recognition of hereditary nephropathies such as LMX1B-associated nephropathy. Coexistence with immune-mediated glomerulonephritis is exceptionally rare. - Source: PubMed
Publication date: 2026/04/16
Sajjad AhsanAmer RidaAlsayed MohammadButt Muhammad DaoudMandayam SreedharSajjad MobeenMasood Attique Ur Rehman - Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycaemia in neonates and infants (blood glucose <3.0 mmol/L in first 2-3 days of life; <3.5 mmol/L after 3 days of life). Diazoxide demonstrates variable efficacy depending on the underlying genetic variant and clinical phenotype. Diazoxide has been associated with side effects that are likely dose dependent. This narrative review synthesizes current evidence on diazoxide's pharmacokinetics and side effect profile to support the development of individualised dosing strategies guided by genotype and patient-specific risk factors, with the aim of optimizing therapeutic outcomes and minimizing adverse effects. - Source: PubMed
Publication date: 2026/03/30
Wong TeresaChan DanielChua CherieCher WenqiLim SelinaChandran SureshYap Fabian