Rab17 (mouse)
- Known as:
- Rab17 (mouse)
- Catalog number:
- Y214016
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Rab17 (mouse)
Related genes to: Rab17 (mouse)
- Gene:
- RAB17 NIH gene
- Name:
- RAB17, member RAS oncogene family
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q37.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-14
- Date modifiied:
- 2015-08-25
Related products to: Rab17 (mouse)
Related articles to: Rab17 (mouse)
- Structural variants (SV) are major drivers of evolutionary processes such as adaptation and speciation, yet their complexity and dynamics in wild populations remain largely unexplored. Avian diversity is highest in the Neotropics, primarily due to the suboscine passerine radiation; however, despite this diversity, genomic resources and studies of SVs in suboscines are scarce compared to their sister clade, the oscine passerines ("songbirds"). Here, we used long-read and chromatin conformation capture sequencing to assemble a high-quality scaffolded reference genome and construct a population-scale pangenome from 5 individuals of the Pearly-vented Tody-Tyrant (Hemitriccus margaritaceiventer), a suboscine bird with plumage variation across its distribution in South American dry forests. Our pangenome graph reveals extensive structural variation, with the chromosomal distribution of SVs strongly predicted by simple and low-complexity repeats - highlighting how specific repeat architecture may influence genome evolution. We discovered intraspecific copy number variation in multigene families, with the most complex instance including beta-keratin genes. Lastly, we identified a 306 kb inversion spanning several melanin pigmentation-associated genes (e.g. MREG, MLPH, RAB17), making it a potential candidate SV for known intraspecific plumage variation. Our study establishes a population-scale pangenome resource for a suboscine bird, enabling characterization of the genome-wide abundance, diversity, and distribution of SVs within this species. - Source: PubMed
Publication date: 2026/05/02
Lopez Kelsie Ade Carvalho Clarissa Ferreirade Lima Hevana SantanaNaka Luciano Nicolásdo Amaral Fabio RaposoBravo Gustavo AEdwards Scott V - Oral squamous cell carcinoma (OSCC) is an aggressive cancer with limited improvement in patient outcomes despite advances in surgery, chemotherapy, and radiotherapy. The LIM-only protein LMO4 functions as a transcriptional co-regulator and is known to be increased in several epithelial cancers, but its contribution to OSCC has not been well defined. In this study, we found that LMO4 expression was markedly higher in OSCC tissues and was associated with poorer overall survival. Cellular experiments showed that LMO4 enhanced OSCC cell proliferation, migration, and resistance to ferroptosis by promoting the ubiquitin-proteasome-dependent degradation of the tumor suppressor RAB17. Restoration of RAB17 expression reduced these malignant behaviors. In a nude mouse xenograft model, tumors with high LMO4 grew faster and displayed lower RAB17 protein levels. Taken together, our results indicate that LMO4 contributes to OSCC progression through post-translational regulation of RAB17 and ferroptosis control, suggesting that this pathway could serve as a new therapeutic target. - Source: PubMed
Publication date: 2025/11/10
Fan JiaJiaZhang HongyanLiu LinWang ChunyuJia ShihengWang QianXu ZengyanZhao FengfeiXiang ShuzhenMa WeiHuang ZhuoranLiu MindaLi YanshuDai Wei - Spinal cord injury (SCI) is a severe and complex condition that can lead to significant physical impairments and affect the life quality of patients. Neural stem cells (NSCs) transplantation holds as a promising therapeutic approach for SCI. However, the challenging post-SCI microenvironment limits NSCs effectiveness. Our current research has found that transplanted NSCs, though with lower survival and differentiation, still aided in injury repair. Hypoxia was identified as a stressor inducing the release of extracellular vesicles (EVs) from NSCs through HIF-1α/RAB17 enhancing SCI repair. By extracting and modifying these EVs derived from hypoxia treated NSCs with CAQK/Angiopep2 peptides, we were able to accurately deliver them to the injury site, enhancing recovery without relying on cell survival or differentiation. This study delved into the reparative role and underlying mechanisms of transplanted NSCs in SCI, focusing on their non-cellular contributions and developed an innovative, targeted strategy for the transplantation of EVs derived from NSCs, offering a cell-free, precision therapeutic intervention for the treatment of SCI. - Source: PubMed
Qin TianQin YimingWen HaichengWu TiandingDuan ChunyueCao YongSun YiZhou HongkangLu HongbinJiang LiyuanHu JianzhongLi Chengjun - Oxyresveratrol, a natural derivative of resveratrol, has been shown to possess antimelanogenic properties. However, the underlying mechanism and its effect on melanin transfer remain poorly understood. In this study, the effects and mechanisms of oxyresveratrol on melanogenesis, dendrite formation, and melanosome transport were investigated. In vitro assays indicated that oxyresveratrol is a potent inhibitor of human tyrosinase, with an IC value of 2.27 µg/mL. Treatment of B16F10 melanoma cells with oxyresveratrol suppressed melanogenesis through the down-regulation of the MC1R/cAMP/MITF signaling pathway. In a co-culture model of B16F10 and HaCaT cells, oxyresveratrol inhibited both melanin transfer and dendrite formation by down-regulating the expression of small GTPases (CDC42, RAB17, RAB11B, RAC1) and the kinesin KIF5B. These findings suggested that oxyresveratrol may serve as a promising therapeutic agent for pigment-related disorders by inhibiting melanogenesis, dendrite formation, and melanosome transport. - Source: PubMed
Publication date: 2025/07/01
Zhang JianhuaLiu ShichaoGuo WenjiaoHuang YunLi Na - Melanin safeguards cells from UV radiation, while also giving them colour (pigmentation). However, excessive melanin production (hyperpigmentation) can cause unwanted side effects such as skin freckles and food browning. As a result, there is a desire to control and in particular reduce melanin production. This study aims to identify bioactive peptides derived from Crocodylus siamensis serum that inhibit tyrosinase, which is a key enzyme in melanin production. We demonstrate hydrolysis of Crocodylus siamensis serum produces peptides that are potent inhibitors of tyrosinase. We demonstrate that alkaline hydrolysis is the most effective method (IC = 0.4323 ± 0.049 μg/μL) and use peptidomic analysis to identify two peptides, HG8 (HIVGRGAG) and RI10 (RNIKASHILI), that are as effective alone as the serum hydrolysate. Our results show that both peptides could inhibit cellular tyrosinase activity and reduce melanin accumulation by down-regulating the expression levels of MITF, TYR, TRP1 and TRP2, which are key regulators of melanogenesis. The peptides also reduce the expression levels of Rab27A, MLPH, Myosin Va, Rab17 and gp100, suggesting they suppress melanosome maturation and transport. Furthermore, both peptides show antioxidant properties in B16F10 cells. These findings hold significant promise for the development of tyrosinase inhibitory peptides as therapeutic agents for hyperpigmentation. - Source: PubMed
Publication date: 2025/02/01
Kwathai MintraTaemaitree LapatradaRoytrakul SittirukDaduang SakdaKlaynongsruang SompongJangpromma Nisachon