Lubricin _ PRG4
- Known as:
- Lubricin _ PRG4
- Catalog number:
- Y213952
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Lubricin _ PRG4
Related genes to: Lubricin _ PRG4
- Gene:
- PRG4 NIH gene
- Name:
- proteoglycan 4
- Previous symbol:
- CACP
- Synonyms:
- JCAP, SZP, MSF, HAPO, bG174L6.2, FLJ32635
- Chromosome:
- 1q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-07-31
- Date modifiied:
- 2016-10-05
Related products to: Lubricin _ PRG4
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- The precise role of hypoxia-inducible factor-1α (HIF-1α) in osteoarthritis (OA) pathogenesis remains controversial, often debated between a protective compensatory factor and a disease mediator. Here, we demonstrate that sustained, uncoupled HIF-1α accumulation functions as a potent, compartment-specific pathogenic driver of joint destruction. Using genetically engineered mouse models, we reveal that chondrocyte-specific HIF-1α overexpression (Acan; Hif1αdPA) triggers spontaneous OA and exacerbates destabilization of the medial meniscus (DMM)-induced post-traumatic joint degeneration. Mechanistically, continuous HIF-1α activation drives pathological angiogenesis that physically dismantles the avascular, hypoxic cartilage niche, forcing a profound metabolic dysregulation that culminates in catastrophic matrix degradation. Conversely, sustained HIF-1α activation within the synovial and superficial cartilage compartments (Prg4- GFPCreERT2; Hif1αdPA) drives a slowly progressive, late-onset spontaneous OA through chronic inflammatory accumulation that actively suppresses Col2a1 expression. Furthermore, this robust inflammatory priming establishes a highly vulnerable microenvironment, whereby DMM surgery significantly accelerates the progression of trauma-induced joint collapse. Finally, transient whole-joint HIF-1α induction via an intra-articular injection of lipid nanoparticles (LNP-mRNA) closely recapitulates these detrimental effects. Collectively, our study reconciles existing controversies by establishing sustained HIF-1α accumulation as a spatiotemporally dynamic, broad disease amplifier across the articular ecosystem, highlighting its targeted inhibition as a promising therapeutic strategy for OA. - Source: PubMed
Gong WeiyuanTao ChuWang XingyunLiao RongdongLi JianglongGuo XiongtianQu MinghaoHuang JianmeiChen MingjueWei FuxinWang PengLin LijunChen DiYao QingWen ChunyiXiao Guozhi - Articular cartilage has a specialised extracellular matrix that provides tensile strength and resistance to compression, but repair capacity is limited. Matrix remodelling during growth is essential for long-term tissue function, yet the underlying protein-level adaptations remain poorly characterised in large-animal models relevant to human joint biology. - Source: PubMed
Publication date: 2026/06/22
Giuffredi GiuliaGisbert MauroFilas Karin VancíkováFalkov JemmaDillon Eugene TMoore SarahLabberté Margot CBrama Pieter A JNowlan Niamh C - Define the natural history of articular joint changes in aging C57BL/6JN mice. - Source: PubMed
Publication date: 2026/06/12
Oviedo ManuelaArnold Katherine MZars Elizabeth LPeralta-Herrera EduardoWeaver Samantha RWestendorf Jennifer J - Lubricin, also known as proteoglycan 4 (), is a key glycoprotein involved in boundary lubrication and maintenance of joint homeostasis in the temporomandibular joint (TMJ). However, the clinical evidence regarding synovial fluid (SF) lubricin levels remains limited and fragmented. This scoping review aimed to map and synthesize the available clinical evidence on lubricin levels in patients with temporomandibular disorders (TMDs) and their relationship to clinical outcomes, particularly pain and mandibular mobility. Searches were conducted in PubMed, Scopus, ACM, BASE, Cochrane, ClinicalTrials.gov, and Google Scholar. After duplicate removal and screening, two studies were included in the final synthesis. Preliminary findings from these studies suggest that (SF) lubricin levels may be lower in more advanced TMJ pathology, particularly in degenerative disease. Earlier stages of internal derangement showed lubricin concentrations closer to those observed in healthy controls, whereas advanced internal derangement and osteoarthritic disease were potentially associated with lower levels. One study also reported an inverse correlation between lubricin concentration and pain intensity, while the other demonstrated impaired boundary lubrication in TMD groups. Overall, the available clinical evidence is very limited and insufficient to establish as a validated biomarker but suggests a possible association between reduced SF lubricin levels and more advanced TMJ disease. Further well-designed clinical studies are required to confirm these observations and clarify their diagnostic and therapeutic relevance. - Source: PubMed
Publication date: 2026/06/02
Sikora PawełChęciński MaciejHorodniczy TomaszChęcińska KamilaTurosz NataliaRomańczyk KalinaHoppe AmeliaSikora Maciej - Rapid glycophenotyping is often limited by biofouling, reliance on complex, multistep labeling, and poor access to living cell surfaces. Here, however, we introduce a glycocalyx-mimetic electrochemical interface that converts lectin-glycan binding into multiplex electrical signals. We coat gold electrodes with a self-assembled brush of lubricin (PRG4), whose densely -glycosylated mucin domains present tumor-associated truncated O-glycans that serve as linkers to the lectins, our recognition elements. Embedding six lectins within lubricin enables orthogonal recognition of Gal-GalNAc-terminated oligosaccharides. In an electrochemical culture-plate format, the resulting sensor supports real-time, in situ glycophenotyping of melanoma cells, achieving quantitative agreement to a conventional, end point, lectin microarray. This glycocalyx-mimetic transducer thus enables the rapid, label-free screening of lectin-glycan interactions and the profiling of diagnostically relevant, tumor-associated glycans. - Source: PubMed
Publication date: 2026/06/09
Coimbra Pimenta ThiagoXavier Mendes AlexandreRath Ronil JAguiar do Nascimento LuizaPithaih VatsalaBellette Henry F FGrills ElizaBehren AndreasPires Souto Dênio EGreene George WrenMoulton Simon EDa Gama Duarte JessicaM Silva Saimon