Foxi2 (mouse)
- Known as:
- Foxi2 (mouse)
- Catalog number:
- Y213931
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Foxi2 (mouse)
Related genes to: Foxi2 (mouse)
- Gene:
- FOXI2 NIH gene
- Name:
- forkhead box I2
- Previous symbol:
- -
- Synonyms:
- FLJ46831
- Chromosome:
- 10q26.2
- Locus Type:
- gene with protein product
- Date approved:
- 2007-05-02
- Date modifiied:
- 2014-11-19
Related products to: Foxi2 (mouse)
Related articles to: Foxi2 (mouse)
- Within feather pattern variation is widespread among chicken breeds globally and is primarily characterized by the distributions of eumelanin on a single feather vane. To analyze the genetic basis underlying different within feather patterns, we conducted the GWAS by pairwise comparing the three common patterns observed in Chinese domestic chickens: stippling, pencilling, and arrow. Based on the coding-region variants, a set of candidate genes were sifted out, notably MC1R, CDH1, MYO5C, FOXI2, and RANBP17, which are functionally associated with melanogenesis and pigment transport. From the perspective of regulatory variants, we integrated GWAS signals with RNA-seq data from growing-phase feather follicles to identify candidates driving transcript-level divergence. With putative regulatory variants, RANBP17, MAPK6, and LOC107051763 were identified as overlapping candidates with differentially expressed genes. Overall, by integrating coding-region and regulatory-region variant analysis, this study identified a set of prioritized candidate genes linked to within feather patterning. This study provides the first systematic genetic dissection of within-feather patterns in domestic chickens by integrating GWAS and RNA-seq, offering new insights into the genetic and developmental mechanisms underlying avian within feather pattern formation. - Source: PubMed
Publication date: 2026/02/14
Guo HuanjieChen YuqiGuo YifanWang BinghuiLi Jingyi - Germ layer specification represents a critical transition where pluripotent cells acquire lineage-specific identities. We identify the maternal transcription factors Foxi2 and Sox3 to be pivotal master regulators of ectodermal germ layer specification in Xenopus. Ectopic co-expression of Foxi2 and Sox3 in prospective endodermal tissue induces the expression of ectodermal markers while suppressing mesendodermal markers. Transcriptomic analyses reveal that Foxi2 and Sox3 jointly and independently regulate hundreds of ectodermal target genes. During early cleavage stages, Foxi2 and Sox3 pre-bind to key cis-regulatory modules (CRMs), marking sites that later recruit Ep300 and facilitate H3K27ac deposition, thereby shaping the epigenetic landscape of the ectodermal genome. These CRMs are highly enriched within ectoderm-specific super-enhancers (SEs). Our findings highlight the pivotal role of ectodermal SE-associated CRMs in precise and robust ectodermal gene activation, establishing Foxi2 and Sox3 as central architects of ectodermal lineage specification. - Source: PubMed
Publication date: 2025/11/04
Hendrickson Clark LBlitz Ira LHussein AminaParaiso Kitt DCho Jin SKlymkowsky Michael WKofron Matthew JCho Ken W Y - This study explores whether DNA methylation (DNAm) mediates the association between lean body mass (LBM) and cognition, as well as whether LBM mediates the association between DNAm and cognition. Based on the data of 59 monozygotic twin pairs, mediation analyses were performed using causal inference test method and mediation analyses. Average causal mediation effect (ACME), average direct effect (ADE), and total effect (TE) were calculated. Among the CpGs associated with LBM, five located within and genes (ACME: -0.0972-0.0463, |ACME/ADE|: 10.44%-18.30%) negatively mediated the association between LBM and cognition, while one in the gene (ACME: 0.3510, |ACME/TE|: 11.84%) positively mediated the association. Besides, the methylation risk score (MRS) of gene (ACME: -0.0517, |ACME/ADE|: 10.64%) and MRS of all CpGs (ACME: -0.0511, |ACME/ADE|: 10.53%) negatively mediated the association of LBM with cognition. For another, LBM negatively mediated the association between the DNAm level of one CpG within and cognition (ACME: -0.0732, |ACME/TE|: 20.78%), while positively mediated the association between the DNAm level of four CpGs within and cognition (ACME: 0.2812-0.4496, |ACME/TE|: 18.15%-27.29%). It was found the DNAm in , and partially mediates the association between LBM and cognition, and the association between DNAm in and with cognition is also partially mediated by LBM. - Source: PubMed
Publication date: 2025/07/14
Li HuihuiWang TongTian XiaocaoZhang DongfengWang Weijing - In vertebrates, germ layer specification represents a critical transition where pluripotent cells acquire lineage-specific identities. We identify the maternal transcription factors Foxi2 and Sox3 to be pivotal master regulators of ectodermal germ layer specification in . Ectopic co-expression of Foxi2 and Sox3 in prospective endodermal tissue induces the expression of ectodermal markers while suppressing mesendodermal markers. Transcriptomics analyses reveal that Foxi2 and Sox3 jointly and independently regulate hundreds of ectodermal target genes. During early cleavage stages, Foxi2 and Sox3 pre-bind to key cis-regulatory modules (CRMs), marking sites that later recruit Ep300 and facilitate H3K27ac deposition, thereby shaping the epigenetic landscape of the ectodermal genome. These CRMs are highly enriched within ectoderm-specific super-enhancers (SEs). Our findings highlight the pivotal role of ectodermal SE-associated CRMs in precise and robust ectodermal gene activation, establishing Foxi2 and Sox3 as central architects of ectodermal lineage specification. - Source: PubMed
Publication date: 2025/01/09
Hendrickson Clark LBlitz Ira LHussein AminaParaiso Kitt DCho JinKlymkowsky Michael WKofron Matthew JCho Ken W Y - In recent decades, substantial advancements in epigenetics have unveiled a profound understanding of its mechanisms in tumorigenesis and have offered promising strategies for epigenetic therapy in cancer patients. In our study, through bioinformatics analysis, we discovered a significant downregulation and hypermethylation of FOXI2 in clear cell renal cell carcinoma (ccRCC), while the expression in chromophobe cell carcinoma (chRCC) exhibited the opposite trend. Moreover, we established a strong correlation between FOXI2 expression levels and the prognosis of ccRCC. Gene enrichment analysis and cell function experiments unequivocally demonstrate that FOXI2 possesses the capability to induce cell cycle arrest and inhibit cell proliferation. Our research findings demonstrate that the expression of FOXI2 in ccRCC is under the regulation of promoter hypermethylation. Furthermore, in vitro experiments have conclusively shown that the overexpression of FOXI2 induces cell cycle arrest and inhibits cell proliferation. - Source: PubMed
Publication date: 2024/04/04
Zhou ShuaiCheng CongLiao Yi XiangWang LiZeng Jin MinZhou Fang FangZhang Xiu QinYang Tao