ASRGL1 _ ALP
- Known as:
- ASRGL1 _ ALP
- Catalog number:
- Y213879
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ASRGL1 _ ALP
Related genes to: ASRGL1 _ ALP
- Gene:
- ASRGL1 NIH gene
- Name:
- asparaginase like 1
- Previous symbol:
- -
- Synonyms:
- FLJ22316, ALP1, ALP
- Chromosome:
- 11q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-29
- Date modifiied:
- 2017-07-14
Related products to: ASRGL1 _ ALP
1H_Indole_3_acetyl chloride, 5_chloro_.alp _20S Proteasome Antibody : Alkaline Phosphatase2_diethylaminoethyl alpha_cyclopentyl_alp 2_diethylaminoethyl alp2_Piperidinemethanamine, 1_methyl_.alp _30 kDa prosomal protein,HC2,Homo sapiens,Human,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,NU,PROS30,PROS-30,Proteasome component C2,Proteasome nu chain,Proteasome subunit alp4(or 5)_(di_1H_indol_1_ylmethyl)_alpha,alp 4(or 5)_(di_1H_indol_1_yl4_Methylumbelliferyl_alpha_L_Idopyranosi 4_Methylumbelliferyl alpAcetylated Lysine Antibody: Alkaline PhosphataseAcetylated Lysine Antibody: Alkaline PhosphataseActin,alpha,Sm. Musc,Clone 1A4,Mab X_Hu,Bov,Gt,Sh,Rb,Ct,Dg,Ms,Rt,Hm,GP,Ch,Viper,Liz,Frg,Snl,Planaria,Crayfish, ALPActin,alpha,Sm. Musc,Clone:1A4,Mab X-Hu,Bov,Gt,Sh,Rb,Ct,Dg,Ms,Rt,Hm,GP,Ch,Viper,Liz,Frg,Snl,Planaria,Crayfish, ALPActinin-associated LIM protein,ALP,Alpha-actinin-2-associated LIM protein,Homo sapiens,Human,PDLIM3,PDZ and LIM domain protein 3ADAM22 (cytoplasmic) Antibody: Alkaline PhosphataseADAM22 (Extracellular) Antibody: Alkaline PhosphataseAHA1 Antibody: Alkaline Phosphatase Related articles to: ASRGL1 _ ALP
- Cancer cells resort to metabolic reprogramming to sustain proliferation. Lung cancer has one of the highest mortality rates of all types of cancer. An important factor in its high mortality rate is its tumors' ability to undergo significant metabolic reprogramming. Phytochemicals can counteract this altered metabolism and exhibit anticancer properties. , a plant used in traditional medicine, has shown such potential. This study evaluated the in vitro cytotoxic activity of its methanolic extract and its effects on the metabolism of HTB-177 lung cancer cells. Qualitative and quantitative phytochemical analysis of this extract was performed to characterize its main constituents. Lung cancer cells were treated with different extract concentrations to evaluate their response to the extract. Cytotoxicity was determined using an MTT assay, and metabolites were analyzed through H-NMR spectroscopy combined with multivariate statistical analysis. Transcriptomic profiling was also conducted to assess gene expression changes in metabolic pathways. Three main phenolic compounds were identified in the extract. The HPLC profile revealed peaks corresponding to gallic acid (GA), ferulic acid (FA), and rosmarinic acid (RA). The extract exhibited cytotoxic activity with an IC of 192.85 µg/mL. Metabolic alterations were observed mainly in glycolysis, the Krebs cycle, and lipid metabolism-key pathways for tumor growth. Transcriptomic data revealed altered metabolism-related genes. The upregulation of ME1 correlated with the observed increase in pyruvate levels, while the downregulation of ALDH7A1 and ASRGL1 was linked to altered amino acid catabolism. Furthermore, transcriptomic data revealed the upregulation of the pro-apoptotic gene HRK. These results indicate that the methanolic extract of possesses cytotoxic activity against lung cancer cells by modulating central metabolic routes and gene expression linked to cancer cell survival and proliferation. - Source: PubMed
Publication date: 2026/03/25
Valdez-Arellanes Ana LRamírez-Cabrera Mónica AArredondo-Espinoza Eder UHernández-Núñez EmanuelSanchez-González Monica NBalderas-Rentería IsaiasRamirez-Estrada Karla - Dementia is increasingly recognized as a condition characterized not only by neurodegeneration but also by significant immune alterations, with potential consequences for both humoral immunity and peripheral gene regulation. However, the relationship between these processes when targeting neuronal and retroviral antigens remains poorly understood. This study investigated immune responses to asparaginase-like protein 1 and human endogenous retroviruses in different types of dementia. Plasma and peripheral blood mononuclear cells were collected from patients with dementia. Antibody reactivity against asparaginase-like protein 1 and human endogenous retroviruses was assayed by enzyme-linked immunosorbent assay, while peripheral gene expression was quantified by qPCR. Group comparisons and correlation analyses were performed. Patients exhibited increased antibody responses against asparaginase-like protein 1 and human endogenous retroviruses despite reduced peripheral expression of the corresponding genes. Within patients, antibodies against asparaginase-like protein 1 were inversely correlated with its transcript levels, whereas antibody responses to human endogenous retroviruses correlated positively with residual gene expression. Immune and transcriptional measures targeting these molecules were interrelated, indicating shared immune pathways. For the first time, this study identifies a coordinated relationship between humoral immune responses and peripheral gene expression in the dementia such as AD, MCI and mixed Dementia offering a novel context for interpreting immune dysregulation and suggesting potential immune-based biomarkers linked to neurodegenerative processes. - Source: PubMed
Publication date: 2026/03/25
Simula Elena RitaErcoli TommasoRuiu ElisaFais MilenaNoli MartaSolla PaoloSechi Leonardo Antonio - Atherosclerosis (AS), a chronic inflammatory disorder of the vasculature, remains the principal driver of cardiovascular disease, accounting for substantial morbidity, mortality, and healthcare burden worldwide. Beyond its vascular implications, recent research highlights the metabolic reprogramming of glutamine (Gln) as a central axis in disease biology. Glutamine metabolism, long recognized for its role in tumorigenesis, is now emerging as a critical determinant of clinical outcomes across diverse cancers, underscoring its broader relevance to pathological processes. - Source: PubMed
Publication date: 2025/12/01
Wang ShiweiZheng ManYang Jing - To explore the immunological mechanisms underlying spermatogenetic malfunction in patients with non-obstructive azoospermia (NOA) based on bioinformatics and machine learning, and to screen out the key genes associated with spermatogenesis failure. - Source: PubMed
Huang Shu-QiangLi Zhi-HongTan Cui-YuChen Miao-QiYuan Xiao-JunChen Wan-RuYang Luo-YaoFeng Xu-NuoChen Cai-RongYan Qiu-Xia - Nasopharyngeal carcinoma (NPC) is an aggressive and highly metastatic malignancy, presenting significant challenges for early diagnosis and treatment. Asparaginase-like protein 1 (ASRGL1) is an important enzyme involved in amino acid metabolism, and previous studies have linked it to the progression of various tumors. However, the specific role of ASRGL1 in NPC remains unclear. This study analyzed multiple publicly available datasets related to NPC. We conducted single-cell RNA sequencing (scRNA-seq) analysis on the GSE150430 dataset to identify different cell subpopulations and examine ASRGL1 expression and its functional implications. The expression of ASRGL1 and its correlation with EMT were validated using transcriptomic data. The expression of ASRGL1 in C666-1 cells was interfered with by siRNA, cell proliferation and invasion were detected by CCK8, EdU, plate cloning, Transwell and scratch method, and EMT was evaluated by detecting the expression of E-cadherin and N-cadherin. Amino acid metabolomics and GC-MS headspace metabolomics were used to analyze the effects of ASRGL1 knockdown on the metabolic pattern of NPC cells. This study found that ASRGL1 was mainly expressed in fibroblasts, epithelial cells and myeloid cells in nasopharyngeal carcinoma (NPC). The ASRGL1-cell gene was significantly enriched in the epithelial-mesenchymal transition pathway. Knocking down ASRGL1 can further inhibit the proliferation, invasion and EMT of C666-1 cells. At the same time, the utilization of various amino acids was significantly reduced, and further GC-MS metabolomics analysis showed that the cell metabolism was unbalanced. This study elucidates the expression characteristics and potential functional roles of asparaginase-like protein 1 (ASRGL1) in nasopharyngeal carcinoma (NPC), providing new insights into its potential as a diagnostic marker and therapeutic target. - Source: PubMed
Publication date: 2025/05/02
Pei YingYingLi ChunlinZhang BinZheng QiChen ShengnanLi Ji