SOX1
- Known as:
- SOX1
- Catalog number:
- Y213855
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- SOX1
Related genes to: SOX1
- Gene:
- SOX1 NIH gene
- Name:
- SRY-box 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 13q34
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-30
- Date modifiied:
- 2015-11-23
Related products to: SOX1
Related articles to: SOX1
- The aim of this study was to assess the impact of SARS-CoV-2 infection during pregnancy on the molecular profile of human milk and to identify associations between the expression of regulatory genes and clinical parameters of newborns. The study included a group of 19 women who had COVID-19 during pregnancy and a healthy control group of 21 women. Expression levels of miR-21, miR-155, and the transcription factor SOX1 were determined in human milk using qPCR. The correlation of SOX1 expression with parameters in cord blood and infant blood was also analyzed. It was shown that maternal SARS-CoV-2 infection (during pregnancy) is associated with significantly higher levels of miR-21, miR-155, and SOX1 expression in human milk. Furthermore, strong statistical correlations were found in the study group: SOX1 expression was positively correlated with C-reactive protein (CRP) levels and lactate concentration (LAC) in arterial umbilical cord blood, while negatively correlated with glucose levels. Our research shows that SARS-CoV-2 infection during pregnancy induces changes in the molecular composition of early breast milk, promoting immunomodulatory (miR-155) and regenerative (miR-21, SOX1) molecules. Post-COVID-19 breast milk serves as an active biochemical communication system, providing the newborn with signals that may modulate adaptive and immune responses to the unfavorable intrauterine environment. - Source: PubMed
Publication date: 2026/04/20
Gil-Kulik PaulinaPrzywara DominikaMitrus MichałPetniak AlicjaKondracki BartoszSzymanowska UrszulaSzymanowski RafałCzuba MonikaKondracka AdriannaKocki Janusz - The TALE homeodomain transcription factors Meis1 and Meis2 are broadly co-expressed during vertebrate organogenesis. They serve as critical regulators of early mouse lens morphogenesis at the lens placodal stage; however, their cooperative roles in subsequent lens morphogenesis remain unknown. Using a BAC-derived Foxe3-Cre driver active in proliferating anterior lens epithelium from embryonic stage E10.5, we conditionally ablated Meis1 and Meis2 individually and in combination and analyzed ocular development from E11.5 to postnatal day P21. Double mutants exhibited early-onset lens hypoplasia and epithelial disorganization detectable by E12.5, progressing to striking postnatal phenotypes characterized by small, highly vacuolated, triangular lenses that frequently detached and floated within malformed anterior segments. At mid-gestation, double mutants showed elevated apoptosis in the emerging lens epithelium and aberrant cell-cycle activity within primary fiber cells. Furthermore, levels of Pax6, FoxE3, Prox1, and Sox1 proteins in lens epithelium were reduced, while Sox2 was ectopically expressed. Junctional and epithelial integrity defects included central loss of ZO-1 and induction of α-smooth muscle actin, while N-cadherin levels were largely unchanged. Anterior segment abnormalities encompassed absence of the anterior chamber and iris-cornea adhesions. By contrast, Meis1-only mutants displayed variable lens and anterior segment defects, including a "big eye" phenotype with optic nerve and retinal ganglion cell abnormalities, whereas Meis2-only mutants were largely normal. These findings identify stage-selective, cooperative functions of Meis1 and Meis2 that maintain Pax6 expression, epithelial integrity, and growth, revealing novel Meis1/2-dependent pathways that are essential for advanced lens morphogenesis. - Source: PubMed
Publication date: 2026/04/16
Smolikova JanaAntosova BarboraLachova JitkaCvekl AlesKozmik Zbynek - Bisphenol A (BPA) has long been used in plastics, resins, and food packaging materials; however, extensive research has demonstrated its reproductive, developmental, and endocrine-disrupting effects. Consequently, BPA has been increasingly restricted and replaced with structural analogues. Among these, tetramethyl bisphenol F (TMBPF) has emerged as one of the most widely used substitutes, particularly in epoxy resins and food-can coatings. Although initially regarded as a safer alternative, accumulating evidence suggests that TMBPF may exert multiple toxicological effects, raising concerns about its potential developmental neurotoxicity. The present study aimed to investigate the neurodevelopmental effects of TMBPF using both in vitro and in vivo approaches. First, a developmental neurotoxicity assay employing Sox1-GFP mouse embryonic stem cells was used to evaluate cytotoxicity using the cell counting kit-8 assay and neural differentiation based on green fluorescent protein (GFP) fluorescence intensity. The results indicated developmental neurotoxic potential according to the established discrimination index. Subsequently, pregnant and lactating mice were exposed to TMBPF daily from gestational day 10.5 to postnatal day 20, and their offspring were assessed for behavioral performance as well as changes in the expression of neurodevelopment-related genes in the brain. Behavioral analyses encompassed multiple domains, including memory and learning, social behavior, anxiety-related responses, and spontaneous locomotor activity, suggesting alterations in these functional outcomes. Molecular analyses further demonstrated changes associated with dopaminergic and cholinergic signaling, synaptic plasticity, neuronal activity markers, neuropeptides, and inflammatory pathways. Collectively, these findings provide the first evidence in a mammalian model that maternal exposure to TMBPF may influence offspring neurodevelopment. These findings suggest potential implications for human exposure to TMBPF, particularly through food-contact materials, and warrant further mechanistic and dose-response studies. - Source: PubMed
Publication date: 2026/04/05
Hwang InhoKim SunJeung Eui-Bae - Malignant neoplastic diseases currently constitute a substantial global health burden. As a class of highly pathologically heterogeneous and complex disorders, addressing malignant tumors necessitates multifaceted efforts across various levels. SOX1, a member of the SOX transcription factor family B subgroup, plays a pivotal role in transcriptional activation during embryonic neurogenesis. Growing evidence indicates that SOX1 also contributes to tumor initiation and progression through multiple mechanisms. While SOX1 exhibits context-dependent functions, its tumor-suppressive action in epithelial cancers frequently involves direct antagonism of the Wnt/β-catenin pathway and downregulation of targets like c-MYC and Cyclin D1. This review synthesizes current insights into the gene function of SOX1 and its roles within oncogenic signaling pathways, which are frequently subject to regulation by epigenetic modifications. The authors further evaluate the potential of SOX1 as a biomarker and therapeutic target in cancer diagnosis, treatment, prognosis, and associated complications. Although the functional heterogeneity of SOX1 presents challenges for clinical application, therapeutic modulation of its upstream and downstream pathways, as well as methylation-based assays for early detection, remain clinically promising. - Source: PubMed
Publication date: 2026/04/03
Zhou XianghuaWang JiaqiYang FanfanGao YufanHou Chunxiao - The development of the central nervous system (CNS) depends on tightly regulated gene expression programs that guide neural progenitor differentiation and neuronal subtype specification. The tunicate provides a powerful and simplified model for dissecting the genetic control of nervous system development, with a larval CNS composed of just over 200 neurons and sensory cells. Although CRISPR/Cas9-mediated mutagenesis is now routinely used in , validated single-guide RNAs (sgRNAs) have yet to be validated for key neural genes. Here, we report the design and experimental validation of 25 novel sgRNAs targeting eight conserved genes encoding conserved proteins involved in neurodevelopment and neural function, including six transcription factors ( and ) and two neural effector genes ( and ). Candidate sgRNAs were selected using CRISPOR and tested for mutagenesis efficiency using Illumina-based target site amplicon sequencing. All sgRNAs induced insertions or deletions at their target loci, with most genes yielding at least one sgRNA with mutagenesis efficacy exceeding 30%, with the exception of , for which maximal efficacy reached 25%. We further compared measured mutagenesis rates with predicted Doench '16 and Doench Ruleset 3 (RS3) scores, observing a modest but improved correlation with RS3 predictions. Based on these results, we recommend considering both scoring algorithms, with RS3 potentially offering improved predictive value for . - Source: PubMed
Publication date: 2026/03/27
Popsuj SydneyKalsang TenzinKim KwantaeDrummond EricaManekar PoojaMunagapati PranavvarmaOleti ManasiSato HirokiVickery IzabellaGigante Eduardo DStolfi Alberto