ABCB5
- Known as:
- ABCB5
- Catalog number:
- Y213833
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ABCB5
Related genes to: ABCB5
- Gene:
- ABCB5 NIH gene
- Name:
- ATP binding cassette subfamily B member 5
- Previous symbol:
- -
- Synonyms:
- EST422562, ABCB5beta, ABCB5alpha
- Chromosome:
- 7p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2016-10-05
Related products to: ABCB5
Related articles to: ABCB5
- Building on the identification of ABCB5 as a marker of limbal stem cells (LSCs), this study examines CD63, a newly identified molecule co-expressed with ABCB5 in limbal epithelial cells, to define its role in maintaining corneal epithelial cell identity. - Source: PubMed
Sasamoto YuzuruSuzuki KoseiSato ShinriLee Catherine A AMartin GabrielleKsander Bruce RFrank Markus HFrank Natasha Y - This study evaluated the sublethal effects of pyraclostrobin (PY) (0.750-12.0 μg/L) and its underlying toxic mechanisms following 28 days of embryonic exposure. PY at ≥3.00 μg/L caused developmental toxicity, characterized by increased larval weight, reduced body length, and hepatic and renal impairment. Different PY concentrations similarly altered glucose, pyruvate, total cholesterol, triglyceride, and free fatty acid levels and the transcription of glycolipid metabolism-related genes. Whole-larvae metabolomics further showed that PY simultaneously disrupted ABC transporters, amino acid biosynthesis, and arginine and proline metabolism pathways. Moreover, strobilurins PY, azoxystrobin, and trifloxystrobin induced and transcription during zebrafish embryo-larvae development. Molecular docking revealed that strobilurins formed hydrophobic interactions with conserved Phe793 and Phe1043 residues in zebrafish ABCB5, whereas no conserved binding interactions were observed with ABCB4, suggesting substrate specificity between strobilurins and ABCB5. This study provides potential molecular targets of PY toxicity and highlights the need to assess its chronic ecological risks. - Source: PubMed
Publication date: 2026/03/07
Jiang JinhuaZhou WenjingFang NanHe HongmeiWang XiangyunLiu XinZhang Changpeng - Pediatric acute myeloid leukemia (AML) is a biologically distinct and aggressive malignancy with limited effective therapies. While emerging targeted agents, including menin, FLT3, and PRMT5 inhibitors, show promise, the transcriptomic effects and the role of extracellular matrix (ECM) regulators, such as nidogen-1 (NID1), in modulating therapeutic responses remain unclear. - Source: PubMed
Publication date: 2026/02/21
Daniel Muteb MuyeyAndwey Gradel Holel - Acylsugars are structurally diverse specialized metabolites secreted by glandular trichomes of Solanaceae plants and play a crucial role in defense against herbivores and pathogens. However, the mechanism underlying acylsugar secretion remains unclear. This study identifies and characterizes the plasma membrane ATP-binding cassette (ABC) transporter Sl-ABCB5 as a key component mediating acylsugar transport in trichome secretory cells of cultivated tomato (Solanum lycopersicum). Using CRISPR-Cas9-generated Sl-ABCB5 knockout mutants, we observed a dramatic reduction in trichome acylsugar accumulation, accompanied by increased susceptibility to western flower thrips (Frankliniella occidentalis). In vitro transport assays using membrane vesicles and protoplasts confirmed the ability of Sl-ABCB5 to transport acylsugars. Furthermore, virus-induced gene silencing and CRISPR-mediated knockout of ABCB5 orthologs in wild tomato (Solanumpennellii) and black nightshade (Solanum nigrum) demonstrated functional conservation of this transporter across Solanaceae species. Together, these findings reveal a conserved acylsugar transport mechanism and establish ABCB5 as a promising target for engineering enhanced insect resistance in Solanaceae crops. - Source: PubMed
Publication date: 2026/02/17
Lyu TaoHan LeiqinJin JianfengWang JianjingZhou HuiyanXu XiaoyanFeng ShanYu JingquanLast Robert LFan Pengxiang - Cutaneous melanoma is one of the most aggressive skin cancers. Over the years, multiple studies have focused on identifying novel treatment strategies, with increasing attention directed toward immune-modulating mechanisms within the tumor microenvironment. Among these, ATP-binding cassette transporters and stem-associated pathways have been shown to influence drug response and immune escape. ABCB5 is a gene with multiple isoforms that significantly influences the immune response. In melanoma, the ABCB5α isoform is predominantly expressed, particularly in tumor stem-like cells where it promotes chemoresistance through active drug efflux. ABCB5 has also been linked to the regulation of PI3K/Akt, BCL-2, and miR-145-associated pathways. Moreover, ABCB5-positive cells contribute to the formation of an immunosuppressive microenvironment by secreting cytokines (IL-6, IL-8, TGF-β) and expressing immune checkpoint ligands, such as PD-L1, thereby favoring tumor progression and a poor prognosis. This review integrates current data on the molecular and microenvironmental mechanisms underlying melanoma progression and therapy resistance, and positions ABCB5 within the broader landscape of melanoma resistance mechanisms, emphasizing both its potential and its current limitations as a biomarker and therapeutic target. - Source: PubMed
Publication date: 2026/01/28
Tinca Andreea CătălinaSabău Adrian HorațiuCozac-Szoke Andreea RalucaChiorean Diana MariaLazar Bianca AndreeaHagău Raluca-DianaCocuz Iuliu GabrielNiculescu RalucaKosovski Irina BiancaMuntean Sofia TeodoraTurdean Sabin GligoreCotoi Ovidiu Simion