ESRRG
- Known as:
- ESRRG
- Catalog number:
- Y213806
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ESRRG
Related genes to: ESRRG
- Gene:
- ESRRG NIH gene
- Name:
- estrogen related receptor gamma
- Previous symbol:
- -
- Synonyms:
- NR3B3, ERRg, ERR-gamma
- Chromosome:
- 1q41
- Locus Type:
- gene with protein product
- Date approved:
- 1998-02-17
- Date modifiied:
- 2018-02-14
Related products to: ESRRG
Anti- Estrogen-Related Receptor Gamma (ERR Gamma NR3B3) (ESRRG) Human AntibodyAnti- Estrogen-Related Receptor Gamma (ERR Gamma/NR3B3) (ESRRG) Human Antibodyanti-ESRRGanti-ESRRGanti-ESRRG ERR3 (N-Terminus)anti-ESRRG / ERR3anti-ESRRG / ERR3anti-ESRRG / ERR3anti-ESRRG / ERR3 (N-Terminus)anti-ESRRG type: Primary antibodies host: MouseAntibodies: ESRRG HOST: Goat Clonality: pAbELISA Kit FOR Estrogen-related receptor gamma; organism: Mouse; gene name: EsrrgERR gamma-2,ERR3,ERRG2,ESRRG,Estrogen receptor-related protein 3,Estrogen-related receptor gamma,Homo sapiens,Human,KIAA0832,NR3B3,Nuclear receptor subfamily 3 group B member 3Err3,Esrrg,Estrogen receptor-related protein 3,Estrogen-related receptor gamma,Kiaa0832,Mouse,Mus musculus,Nr3b3,Nuclear receptor subfamily 3 group B member 3Errg,Esrrg,Estrogen receptor-related protein 3,Estrogen-related receptor gamma,Nr3b3,Nuclear receptor subfamily 3 group B member 3,Rat,Rattus norvegicus Related articles to: ESRRG
- Early pregnancy is a highly coordinated process requiring precise embryo-maternal communication. Estradiol-17β (E2) is considered the primary conceptus-derived signal responsible for the maternal recognition of pregnancy in pigs. Successful pregnancy establishment requires two distinct peaks of E2 secretion by porcine conceptuses: during days 11-12 (the maternal recognition of pregnancy) and days 15-30 (implantation). Although the role of E2 in signaling to the maternal system is well established, its potential autocrine effects on conceptus development remain unclear. This study examined whether E2 regulates trophoblast function during the maternal recognition of pregnancy and implantation. We demonstrated that expression of estrogen receptors (ESR1, ESR2, GPER1) and selected pregnancy-related genes (FOXO3, GDF15, SERPINE1, ESRRB, ESRRG) changes during early pregnancy in the pig. E2 regulated the gene expression of its receptors (ESR1, ESR2, GPER1), genes involved in E2 synthesis (HSD17B1), prostaglandin synthesis (PTGS2, AKR1C4, PTGES), and key mediators of pregnancy establishment (IL1B2, SERPINE1, FOXO3, GDF15, ESRRB and ESRRG). Furthermore, E2, acting via nuclear estrogen receptors, enhanced trophoblast cell proliferation on days 12 and 15 of pregnancy, and increased adhesion as well as MAPK1/3 and PTK2 protein phosphorylation on day 15 of pregnancy. E2 stimulated cell proliferation via MAPK and PI3K/AKT/mTOR pathways, whereas E2-promoted adhesion was mediated via MAPK and PI3K/AKT signaling. Concluding, these findings indicate that E2 functions not only as a critical embryonic signal for the maternal recognition of pregnancy but also plays an autocrine role in conceptus development, regulating gene expression and trophoblast cell function during early gestation in pigs. - Source: PubMed
Publication date: 2026/04/11
Goryszewska-Szczurek EwelinaWaclawik Agnieszka - Hepcidin (encoded by the HAMP gene), produced primarily by hepatocytes, is the master regulator of systemic iron homeostasis, and its dysregulation contributes to various iron-related metabolic disorders. Cereblon (CRBN) has been implicated in metabolic regulation, while estrogen-related receptor gamma (ESRRG) is known to govern energy homeostasis and mitochondrial function. Here, we demonstrate a novel CRBN-ESRRG signaling pathway that mediates endoplasmic reticulum (ER) stress-induced hepatic HAMP expression. In mice and primary hepatocytes exposed to tunicamycin-induced ER stress, gene expression and biochemical analyses revealed that hepatic Crbn, Esrrg, and Hamp transcript levels were significantly increased. Hepcidin protein levels were correspondingly elevated, accompanied by reduced serum iron levels and increased cellular iron levels, consistent with hepcidin-mediated regulation of iron distribution. Overexpression of Crbn enhanced ESRRG expression and increased hepatic hepcidin production, whereas Crbn or Esrrg knockdown attenuated this response. Chromatin immunoprecipitation assays demonstrated enhanced ESRRG recruitment to the Hamp promoter. Collectively, these findings identify a CRBN-ESRRG regulatory axis that drives hepatic HAMP expression under ER stress and suggest a potential therapeutic target for ER stress-associated metabolic and iron disorders. - Source: PubMed
Publication date: 2026/04/06
An SeungwonKang Chung HyoPark TaehyunNedumaran BalachandarSung YounjooChung TaehoonPark Chul-SeungDjalilian Ali RKim Yong Deuk - Alternative splicing plays a critical role in cardiac development and function and becomes dysregulated in heart failure. Although splicing defects have been described in both dilated (DCM) and ischemic (ICM) cardiomyopathy, the extent to which these alterations contribute to disease mechanisms and how they are spatially distributed across cardiac regions remains poorly understood. This study aimed to profile alternative splicing events across the left ventricle (LV), right ventricle (RV), and interventricular septum (IVS) in end-stage heart failure patients with DCM and ICM, and to investigate potential regulatory factors driving these changes. - Source: PubMed
Publication date: 2026/03/24
Furtado MartaBarbosa PedroWemans AnaZhang LuLumley AndrewCarvalho TeresaNapoleão PatríciaLeszek PrzemyslawCarmo-Fonseca MDevaux YvanMartins Sandra - Preeclampsia (PE) is a life-threatening obstetric complication, and DNA methylation and immune system disorders play a key role in its development. This study aimed to explore the potential mechanisms and values of abnormally methylated immune-related differentially expressed genes (DEGs) in PE. Gene expression profiles and methylation data of PE were downloaded from the Gene Expression Omnibus (GEO) database. Immune-related genes were downloaded from the ImmPort database. Subsequently, differential expression analysis, functional annotation, immune cell infiltration analysis, Pearson correlation analysis, construction of classification models and miRNA-mRNA interaction network, and real-time PCR validation were carried out. Ten key abnormally methylated immune-related DEGs (ESRRG, FGF10, AHNAK, STC2, PPARG, LTF, MX1, ESR1, RELB, and JAG2) were identified and may be potential diagnostic biomarkers for PE. The decision tree (DT), random forests (RF), and support vector machine (SVM) classification models constructed based on these 10 genes exhibited a certain level of diagnostic accuracy. Compared with a single DEG, these classification models may have relatively higher diagnostic reference value. Functional annotation results showed that rap1, PI3K-Akt, and calcium signaling pathways may play a regulatory role in PE. The infiltration levels of monocytes, M2 macrophages, neutrophils, Tregs, and eosinophils in the PE group were abnormal. Key abnormally methylated immune-related DEGs were significantly correlated with the infiltration levels of immune cells. Moreover, 6 miRNA-mRNA pairs (hsa-miR-181b-5p-ESR1, hsa-miR-152-3p-ESR1, hsa-miR-26b-3p-ESR1, hsa-miR-4672-ESRRG, hsa-miR-502-3p-AHNAK, and hsa-miR-3059-5p-STC2) were identified. Key abnormally methylated immune-related DEGs may be associated with the immune mechanism of PE, given their correlation with related signaling pathways and immune cell infiltration. - Source: PubMed
Publication date: 2026/03/09
Yuan YuanWang QinSu XiaoZhong Lu - Early spontaneous abortion (ESA) is recognized as the most common complication during pregnancy and is often linked to dysfunction in the trophoblast and placenta. Studies suggest that downregulation of trophoblast oestrogen-related receptor gamma (ESRRG) may play a significant role in the impairment of placental function. In light of these findings, we evaluated the impact of ESRRG on trophoblast and placental function in ESAs, aiming to uncover new targets for diagnosis and treatment. - Source: PubMed
Publication date: 2026/02/02
Lv ShaLi LieyangXu XiaoxiaoLiang ZhengweiZhang RongruiZhou ZunlunLu Deqin