BNIP1
- Known as:
- BNIP1
- Catalog number:
- Y213707
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- BNIP1
Related genes to: BNIP1
- Gene:
- BNIP1 NIH gene
- Name:
- BCL2 interacting protein 1
- Previous symbol:
- -
- Synonyms:
- Nip1, SEC20
- Chromosome:
- 5q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-03-19
- Date modifiied:
- 2016-06-21
Related products to: BNIP1
Related articles to: BNIP1
- Mature cow weight (MWT), height (MHT), and body condition score (BCS) are economically important traits that significantly influence cowherd profitability by affecting maintenance feed requirements, which is the largest component of production costs. This study aimed to identify genomic regions, candidate genes, and pleiotropic variants associated with mature cow size traits in American Angus cattle, and to characterize their related gene ontology terms and metabolic pathways. The dataset provided by the American Angus Association comprised 434,746 MWT records from 222,907 animals; 213,875 MHT records from 112,987 animals; and 382,156 BCS records from 209,696 animals. Of these, 45,606 cows were genotyped and imputed to a common marker density of 54,609 markers. A final dataset of 51,410 SNPs from 45,452 animals remained after quality control for further analyses. The single-step genome-wide association study (ssGWAS) method was used in the analyses. Significant associations for mature cow size were detected on BTA7, BTA14, and BTA20, overlapping with previously reported QTLs for growth, feed efficiency, and carcass traits. Candidate genes such as , , , , , and were found to be related to muscle development, skeletal growth, lipid metabolism, and energy regulation. The genes , , , , , , , , , , and emerged as candidate genes exhibiting pleiotropic effects on mature cow size traits. Pathway enrichment highlighted the roles of insulin/IGF1R signaling, fibroblast growth factor receptors cascades, and mitogen-activated protein kinase pathways in MWT and MHT, while for BCS, only RHOD GTPase cycle was enriched. Pleiotropy-based analysis of regions affecting mature cow size traits identified shared genomic loci, and subsequent pathway analysis revealed G protein signaling as a common regulatory mechanism linking energy balance, adiposity, and growth. These results contribute to a better understanding of the genomic regions associated with mature cow size traits in Angus cattle. - Source: PubMed
Publication date: 2026/04/06
Ojo Ayooluwa OMulim Henrique ACampos Milena A FGarcia AndréRetallick-Riley KelliFonseca Pablo A SOliveira Hinayah R - RNF185 is a mitochondrial RING-type E3 ubiquitin ligase known to regulate mitochondrial homeostasis, apoptosis, and innate immune signaling through ubiquitination of substrates such as BNIP1, JWA, and cGAS. Although dysregulation of RNF185 has been reported in several cancers, its role in esophageal squamous cell carcinoma (ESCC) remains unclear. The present study aimed to investigate the function of RNF185 in ESCC progression and assess its potential as a therapeutic target. - Source: PubMed
Publication date: 2025/11/18
Wang Ke-HaoZhu HuiXu Meng-DanWang Yi-PingFan Qing-QingCen Dan-PingWang Shu-Jun - Depression is a heterogeneous psychiatric disorder with limited treatment efficacy, as 30-50% of patients exhibit inadequate responses to conventional monoaminergic antidepressants. Rhein, a bioactive anthraquinone derived from Rheum palmatum, exhibits rapid and sustained antidepressant effects in both acute and chronic social defeat stress (CSDS) mouse models. Using quantitative proteomics on prefrontal cortex (PFC) samples from control, CSDS, Rhein-treated, and imipramine-treated cohorts, we identified differentially expressed proteins that revealed Rhein's multi-target regulatory profile. Functional enrichment and clustering analyses indicated that Rhein predominantly restores dysregulated pathways related to lipid metabolism, ribosomal translation, mitochondrial and endoplasmic reticulum (ER) function, and synaptic plasticity, forming a coherent mechanistic axis underlying its therapeutic effects. Comparative analysis with imipramine-treated mice further highlighted Rhein's distinct capacity to modulate organelle homeostasis and synaptic remodeling with greater breadth. Parallel reaction monitoring (PRM) and Western Blotting validated key proteins involved in mitochondrial functions (BNIP1, PISD, MRPL42, MRPS30, LRBA, IGHM), ER homeostasis (ACBD5, APOA4, RPL14), and synaptic plasticity (HDAC1, FAM3C, SSU72). These molecular findings suggest that Rhein exerts its antidepressant effects by restoring the functional integrity of mitochondria and the ER, thereby reprogramming synaptic plasticity. We inferred that this organelle-centered regulation further reinforces its potent modulation through multiple mechanisms and signaling pathways of synaptic plasticity, enabling Rhein to exert antidepressant effects through a coordinated, multi-layered mechanism. Collectively, our findings provide a systems-level mechanistic framework for Rhein's antidepressant efficacy and support its potential as a multi-pathway natural therapeutic, particularly for metabolic subtypes of depression. - Source: PubMed
Publication date: 2025/11/14
Ge ZiyuYang YangChen PeiKan WeijingLi LeiXu JiyiZhang YiGuo YumengZheng NanZhang WanjunZhang ChenhuiSun SiduoWang TianyiWang GangDu Jing - Runs of homozygosity (ROHs) are continuous homozygous segments of genomes that can be used to infer the historical development of the population. ROH studies allow us to analyze the genetic structure of a population and identify signs of selection. The present study searched for ROH regions in the Faverolle chicken breed. DNA samples from modern individuals and museum Faverolle specimens were obtained and sent for whole-genome sequencing (WGS) with 30× coverage. The results were aligned to the reference genome and subjected to additional filtering. ROH segments were then analyzed using PLINK 1.9. As a result, 10 regions on GGA1, 2, 3, 4, and 13 were identified. A total of 19 genes associated with fat deposition and lipid metabolism (, , , , , , , , ), fertility (, , ), muscle development and body weight (, , , , ), the shape and relative size of the skeleton (), and autophagy and apoptosis () were found. Developmental protein genes (, , , ) formed a separate cluster. Probably, selection for the preservation of high flavor characteristics contributed to the consolidation of these ROH regions. The present research enhances our knowledge on the Faverolle breed's genome and pinpoints their ROH segments that are also specific «selection traces». - Source: PubMed
Publication date: 2025/05/20
Ryabova Anna EAzovtseva Anastasiia IShcherbakov Yuri SDysin Artem PDementieva Natalia V - Skeletal dysplasias are a clinically and genetically heterogeneous group of rare disorders. Studies from large cohorts are essential to provide insights into the disease epidemiology, phenotypic spectrum, and mutational profiles. Here we enumerate additional 248 Indians from 197 families with a skeletal dysplasia, following a similar study earlier. We achieved a clinical-molecular diagnosis in 145 families by targeted analysis in 37 and next generation sequencing (exomes and genomes) in 108 families that resulted in a diagnostic yield of 73.6% (145 of 197 families). We identified 149 causal variants, of which 85 were novel, across 73 genes. Eighty-one distinct monogenic forms of skeletal dysplasia were observed with a high proportion of autosomal recessive skeletal dysplasias (60%, 84 families). We observed consanguinity in 35% of the families. Lysosomal storage diseases with skeletal involvement, FGFR3-related skeletal dysplasia and disorders of bone mineralisation were most frequent in this cohort. We expand the phenotypic and genotypic spectrum of rarely reported conditions (RAB33B, TRIP11, NEPRO, RPL13, COL27A1, PTHR1, EXOC6B, PRKACA, FUZ and RSPRY1) and noted novel gene-disease relationships for PISD, BNIP1, TONSL, CCN2 and SCUBE3 related skeletal dysplasia. We successfully implemented genomic testing for skeletal dysplasia in clinical and research settings. Our study provides valuable information on the spectrum of skeletal dysplasia and disease-causing variants for Asian Indians. - Source: PubMed
Publication date: 2024/12/20
Jacob PrinceSingh SwatiBhavani Gandham SriLakshmiGowrishankar KalpanaNarayanan Dhanya LakshmiNampoothiri SheelaPatil S JSoni J PMuranjan MamtaKapoor SeemaDhingra BhavnaBhat Ballambattu VishnuBajaj ShrutiBanerjee AmritaMamadapur MahabaleshwarHariharan Sankar VKamath NutanShenoy Rathika DSuri DeeptiShukla AnjuDalal AshwinPhadke Shubha RNishimura GenMortier GeertShah HiteshGirisha Katta M