Ogg1 (mouse)
- Known as:
- Ogg1 (mouse)
- Catalog number:
- Y213699
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Ogg1 (mouse)
Related genes to: Ogg1 (mouse)
- Gene:
- OGG1 NIH gene
- Name:
- 8-oxoguanine DNA glycosylase
- Previous symbol:
- -
- Synonyms:
- HMMH, HOGG1, OGH1, MUTM
- Chromosome:
- 3p25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-22
- Date modifiied:
- 2016-10-05
Related products to: Ogg1 (mouse)
Related articles to: Ogg1 (mouse)
- Aberrant activation of the NLRP3 inflammasome contributes to a wide range of chronic inflammatory disorders. Here, we investigate small-molecule inhibitors originally developed to target the DNA repair enzyme hOGG1 and demonstrate their ability to inhibit NLRP3 activation in human cells. These compounds, including TH5487 (IC50 1.62 µM in human PBMCs), reduce IL-1β secretion while increasing type I interferon responses. Cryo-EM reveals direct association between NLRP3 and mitochondrial DNA, while structural modeling predicts interaction with oxDNA. Notably, inhibitors of the DNA repair glycosylase hOGG1 remain effective in L353P mutant PBMCs from FCAS patients and L351P in mice, at doses where the canonical NLRP3 inhibitor MCC950 is ineffective. Our findings uncover an additional druggable mechanism for inflammasome regulation via interference with oxidized DNA sensing, offering innovative therapeutic opportunities for autoinflammatory disease. - Source: PubMed
Publication date: 2026/04/16
Lackner AngelaPicucci Sofia IJiang WenjinOnyuru JansetCampos MelissaCabral Julia ELeonidas LemuelMacapagal AlijahLee HannahHenriquez ValerieWang KarenXu HuilinQiu YanfeiAlbrecht Lauren VHoffman Hal MMcNulty Reginald - Saline-alkaline (SA) soils pose a serious threat to soybean production worldwide. Although severe saline-alkaline stress can reduce yield by up to 30%, the mechanisms underlying saline-alkaline-induced inhibition of root growth remain unclear. In this study, two soybean cultivars with contrasting tolerance, Chang Nong 26 (CN26) and Jiyu 441 (JY441), were exposed to saline-alkaline stress induced by NaHCO and NaCO at Na concentrations of 0, 21, and 45 mmol·L. The effects on seed germination, early seedling growth, antioxidant responses, and root DNA damage were systematically examined. High-level saline-alkaline stress significantly inhibited germination and root elongation in both cultivars. Superoxide dismutase (SOD) and peroxidase (POD) activities increased markedly under stress, indicating activation of antioxidant defenses. Catalase (CAT) and ascorbate peroxidase (APX) to scavenge ROS and maintain cellular redox balance. Nevertheless, oxygen-free radicals (OFRs) accumulated to a significantly greater extent in the root tips of CN 26 than in JY441, suggesting lower tolerance in CN 26. Random amplified polymorphic DNA (RAPD) analysis revealed pronounced DNA damage in root tips under saline-alkaline stress, with more polymorphic bands detected in CN 26 than in JY441. Furthermore, qRT-PCR analysis demonstrated that the expression of DNA damage repair-related genes (, , , and ) was downregulated in CN 26 roots under stress, whereas and expression was upregulated. In contrast, these DNA repair genes in JY441 were significantly induced during the early stage of stress exposure and subsequently declined. Collectively, this study demonstrates that saline-alkaline stress inhibits soybean growth through the induction of oxidative DNA damage and cell cycle arrest in roots. The reduced capacity for DNA repair in CN 26 likely contributes to its greater sensitivity to saline-alkaline stress. This study provides mechanistic insights into saline-alkaline stress-induced growth inhibition in soybean and offers a theoretical basis for breeding stress-tolerant cultivars. - Source: PubMed
Publication date: 2026/04/07
Yang GegeSun RuiZhang YingyiSong JiaxinLi JiahuiLuan ZhihuiQi Wenjing - Glioblastoma (GBM) is the most prevalent primary brain tumor. Despite extensive investigations, GBM's resistance to the first-line drug temozolomide (TMZ) remains a major challenge in clinical management. This study explores the molecular mechanisms underlying TMZ resistance in GBM, emphasizing the roles of DNA repair gene polymorphisms and intratumoral genetic heterogeneity. - Source: PubMed
Publication date: 2026/04/10
Chen WeixuanLi CongLiu YunHuang Hengji - The aging brain is highly vulnerable to oxidative genomic damage, the accumulation of which is a hallmark of Alzheimer's disease (AD). The base excision repair (BER) pathway, initiated by DNA glycosylases, serves as the primary guardian against such damage. This review synthesizes recent evidence revealing the dual and dynamic roles of key DNA glycosylases including OGG1, MUTYH, MPG, and members of the NEIL family in AD pathogenesis. Beyond canonical repair functions, these enzymes actively participate in core pathological processes including Aβ/tau toxicity, neuroinflammation, and neuronal death, with their activities modulated by the AD microenvironment. We evaluate the therapeutic strategies targeting these enzymes, highlighting emerging strategies like OGG1 agonists for early-stage repair enhancement and inhibitors for dampening maladaptive inflammation in later stages. Finally, we propose a precision medicine approach based on a deeper understanding of glycosylase biology in distinct brain cell types and disease stages, providing a theoretical foundation for DNA repair-targeted interventions in AD. - Source: PubMed
Publication date: 2026/04/10
Zhao XiaLi YingzhouMeng ZiyaoXu XiaoxiaChen LinjieYu QinWang RuyaRen YiyuChen FanAi QiDeng YuYu HoumingWei JuruiLiang Guang - Aim: Validate the association RAD18 Arg302Gln (rs373572) and OGG1 Ser326Cys (rs1052133) - with Renal Cell Carcinoma (RCC) susceptibility and histopathological characterization. - Source: PubMed
Altemimi Iftikhar Khdhair AbbasAmeen Binan Adil MohammedAl-Terehi Mona NHussein Liwaa Mahdi