AIP _ ARA9
- Known as:
- AIP _ ARA9
- Catalog number:
- Y213690
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AIP _ ARA9
Related genes to: AIP _ ARA9
- Gene:
- AIP NIH gene
- Name:
- aryl hydrocarbon receptor interacting protein
- Previous symbol:
- -
- Synonyms:
- XAP2, ARA9, FKBP16
- Chromosome:
- 11q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-22
- Date modifiied:
- 2019-04-23
Related products to: AIP _ ARA9
Addicsin,ADP-ribosylation factor-like protein 6-interacting protein 5,Aip5,Aip-5,ARL-6-interacting protein 5,Arl6ip5,Glutamate transporter EAAC1-interacting protein,GTRAP3-18,Jwa,Mouse,Mus musculus,PRADP-ribosylation factor-like protein 6-interacting protein 5,Aip-5,ARL-6-interacting protein 5,ARL6IP5,Bos taurus,Bovine,PRA1 family protein 3,PRAF3ADP-ribosylation factor-like protein 6-interacting protein 5,Aip-5,ARL-6-interacting protein 5,ARL6IP5,Chicken,Gallus gallus,PRA1 family protein 3,PRAF3,RCJMB04_3k9ADP-ribosylation factor-like protein 6-interacting protein 5,Aip-5,ARL-6-interacting protein 5,ARL6IP5,Cytoskeleton-related vitamin A-responsive protein,Dermal papilla-derived protein 11,DERP11,GlutamADP-ribosylation factor-like protein 6-interacting protein 5,Aip-5,ARL-6-interacting protein 5,Arl6ip5,Glutamate transporter EAAC1-interacting protein,GTRAP3-18,Gtrap3-18,Jwa,PRA1 family protein 3,PraADP-ribosylation factor-like protein 6-interacting protein 5,Aip-5,ARL-6-interacting protein 5,ARL6IP5,Pig,PRA1 family protein 3,PRAF3,Sus scrofaAH receptor-interacting protein - AIP; Aryl-hydrocarbon receptor-interacting protein PolyclonalAH receptor-interacting protein - AIP; Aryl-hydrocarbon receptor-interacting protein; Immunophilin homolog ARA9; HBV X-associated protein 2; XAP-2 PolyclonalAH receptor-interacting protein - AIP; Aryl-hydrocarbon receptor-interacting protein; Immunophilin homolog ARA9; HBV-X-associated protein 2 PolyclonalAIMP1 Gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1AipAIPAipAIPAIP XAP2 antibody Ab host: Rabbit Related articles to: AIP _ ARA9
- Mobile genetic elements (MGEs), including LINE-1 retrotransposons, Alu and SVA elements, and human endogenous retroviruses (HERVs), constitute nearly half of the human genome and are increasingly understood to influence multiple dimensions of cancer evolution. Yet, pituitary neuroendocrine tumors (PitNETs) remain almost absent from mobilome research, despite exhibiting genomic and epigenetic contexts permissive to retroelement activation. In this review, we synthesize current evidence linking MGEs to PitNET biology and delineate unresolved but testable mechanisms. Structural genomic studies demonstrate that Alu-mediated non-allelic homologous recombination contributes to germline mutagenesis in MEN1 and AIP, reinforcing the notion that repetitive DNA architecture shapes PitNET predisposition. Transcriptomic analyses reveal global derepression of transposable elements and LINE-1 hypomethylation in subsets of tumors, while mechanistic connections to chromatin instability emerge from recurrent ATRX/DAXX deficiency and TP53 inactivation, both established repressors of retroelements. Furthermore, the retrocopy-derived long non-coding RNA RPSAP52 exemplifies how mobilome-origin transcripts can be co-opted as oncogenic regulators in PitNETs, acting through HMGA2-dependent proliferative networks. Preliminary data also suggest endogenous retroviral activation, with consistent upregulation of HERV envelope genes across distinct tumor subtypes. Nevertheless, no study has yet systematically mapped somatic mobile-element insertions (MEIs), quantified LINE-1 protein activity, or profiled HERV expression at locus resolution in PitNETs. Mobilome biology represents a tractable and conceptually rich frontier with diagnostic, prognostic, and therapeutic potential in pituitary tumorigenesis. - Source: PubMed
Publication date: 2026/04/21
Batista Rafael LochDa Roz D'Alessandre NatháliaCraveiro Flora LadeiraMarques Juliana MoreiraChaves Elisa FrançaArantes Dos Santos GabrielAgopian Guardia Gabriela DerFavoretto Galante Pedro Alexandre - Autoimmune pancreatitis (AIP) is a chronic pancreatic inflammatory disease that is often difficult to differentiate from pancreatic cancer. Some AIP patients may even progress into pancreatic ductal adenocarcinoma (PDAC). We sought to delineate the peripheral immunological landscape of AIP, identify its differences from PDAC and find novel biomarkers for disease differentiation. - Source: PubMed
Liu ChenxiaoChe TianyiLiu AiruWang JiaxinYang QidiTu YiwenLiu ZonghaoShen XiaonanHe XiangyiGong TingtingZhang LingSong ZhengjiFan JunjieZeng YueZou WenbinYe YouqiongZhang YaoZhang MinminZou DuowuZhou Chunhua - - Source: PubMed
Publication date: 2026/04/20
Marino Picciola ValentinoCrociara AnnaPiacentini SerenaRossi LucreziaAmbrosio Maria RosariaGessi Marcod'Amati AntonioRubini MicheleZatelli Maria Chiara - IgG4-related autoimmune pancreatitis (AIP) can resemble pancreatic ductal adenocarcinoma (PDAC), but it typically presents as a solid mass rather than a cystic-solid lesion. We report a rare case of AIP in a middle-aged man with a long-standing pancreatic tail mass that gradually enlarged and developed a cystic-solid configuration. Photon-counting CT showed a non-enhancing cystic component and a progressively enhancing solid portion with apparent invasion of adjacent organs, while FDG-PET/CT demonstrated marked metabolic activity, all strongly suggestive of malignancy. Serum IgG4 levels were normal and no extrapancreatic IgG4-related involvement was present. The patient declined biopsy and underwent radical surgery; histopathology revealed dense fibrosis, pancreatic atrophy, and lymphoplasmacytic infiltration consistent with IgG4-related AIP, with no evidence of cancer. This case highlights that atypical cystic-solid AIP can closely mimic invasive PDAC even with advanced imaging techniques, underscoring the importance of recognizing such rare presentations to avoid unnecessary radical resection. - Source: PubMed
Publication date: 2026/04/02
Xiao RanLi TianyuChen BoZhu LiangDong LiangboWang YaozongQiu XiaoyuanLiu JingyiBai MingliangHan JiashuLin ChenWang Weibin - Acute intermittent porphyria (AIP) is a rare metabolic disorder characterized by neurovisceral manifestations, most commonly severe abdominal pain. Thrombotic complications are not typically associated with AIP and are infrequently reported in atypical venous territories. Gonadal vein thrombosis (GVT) is an uncommon condition most frequently observed in the postpartum period or in association with pelvic infections and malignancy; its occurrence in patients with AIP is exceptionally rare. GVT is a potentially serious form of deep vein thrombosis, often underdiagnosed due to its nonspecific presentation. We report the case of a 53-year-old woman with genetically confirmed AIP, a history of recurrent venous thromboembolism, and poorly controlled type 2 diabetes mellitus, who presented with acute lower abdominal pain radiating to the groin and back, accompanied by gastrointestinal symptoms. Contrast-enhanced computed tomography demonstrated an acute right GVT and a concurrent nonocclusive pulmonary embolism. Initial laboratory investigations revealed hyponatremia, mild transaminitis, and hyperglycemia. The overlapping abdominal manifestations of AIP initially complicated the diagnostic process; however, the presence of focal groin and back pain prompted further evaluation, leading to a timely diagnosis. The patient was managed with porphyria-safe antibiotics, therapeutic anticoagulation, and supportive care, resulting in clinical improvement. This case underscores the importance of maintaining a high index of suspicion for uncommon thrombotic complications in patients with AIP who present with new or atypical pain patterns. Early recognition and careful selection of porphyria-safe therapeutic strategies are critical to prevent complications and optimize clinical outcomes. - Source: PubMed
Publication date: 2026/03/19
Goranti JyothsnaNeri Rosario DanielChohonis Kelly