MDA5 _ Ifih1 (mouse)
- Known as:
- MDA5 _ Ifih1 (mouse)
- Catalog number:
- Y213689
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- MDA5 _ Ifih1 (mouse)
Related genes to: MDA5 _ Ifih1 (mouse)
- Gene:
- IFIH1 NIH gene
- Name:
- interferon induced with helicase C domain 1
- Previous symbol:
- -
- Synonyms:
- MDA-5, Hlcd, MDA5, IDDM19
- Chromosome:
- 2q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-25
- Date modifiied:
- 2019-04-23
Related products to: MDA5 _ Ifih1 (mouse)
Related articles to: MDA5 _ Ifih1 (mouse)
- Probiotics have been widely used in aquaculture. Host-derived probiotics offer advantages in intestinal adhesion and colonization. This study characterized probiotic properties of Latilactobacillus sakei MG6, a gut-derived strain, and evaluated its effects on immune modulation, nutrient metabolism, and intestinal microbiota community of turbot (Scophthalmus maximus). Samples were collected at the following time points: CON (day 0, diet without MG6 supplementation), days L1-7 (days 1, 2, 3, and 7, turbots fed diets with MG6 supplementation), and days S3-7 (days 3 and 7, after post-cessation). In vitro assays revealed that L. sakei MG6 exhibited strong acid tolerance, bile salt resistance, and high auto-aggregation. And the cell-free supernatant of L. sakei MG6 showed antimicrobial activity against Vibrio anguillarum, Vibrio alginolyticus, and Vibrio scophthalmi. In vivo, the results demonstrated that compared to CON, dietary MG6 significantly enhanced respiratory burst activity at days L1 and S3, increased serum total protein, albumin, and globulin levels at day L1. The expressions of immune related genes IL-8, IL-1β, IL-10, TGF-β, MHC-I, and IFIH1 in the head kidney were also upregulated by dietary MG6 at days L3 and L7. Concurrently, the digestive enzyme activities were also significantly elevated by MG6 at days L3 and L7. Dietary MG6 reshaped gut microbial community, with L7 exhibiting enriched microbial diversity, stabilized co-occurrence networks, and positive correlations with nutrient metabolism pathways. However, the turbot showed disrupted intestinal homeostasis and impaired nutrient absorption at S3. These results demonstrated that L. sakei MG6 can effectively colonize the turbot intestine, synergistically enhance immune function, metabolic efficiency, and intestinal microbial resilience, supporting its application as a functional feed additive for sustainable aquaculture. The alternate feeding strategy of MG6 (Cessation of MG6 supplementation) induces intestinal dysbiosis and metabolic dysregulation in turbot, whereas continuous MG6 supplementation may demonstrate superior benefits for host health. - Source: PubMed
Publication date: 2026/05/12
Liu QianhuiOu WeihaoZhao JingjingGe XiaoyuanMai KangsenZhang Yanjiao - Adenosine deaminase acting on RNA 1 (ADAR1) deaminates adenosine to inosine in dsRNA. ADAR1 RNA editing marks cellular dsRNA as self, preventing aberrant activation of the antiviral dsRNA sensor MDA5. Adar Ifih1 (MDA5) or Adar Mavs double mutant pups escape Adar mutant aberrant interferon induction but die early. Here, we show that long-lived Adar Mavs Eif2ak2 (PKR) mice display a new residual defect: failure to maintain blood CD8+ T cells due to loss of an editing-independent function of ADAR1. Further dsRNA sensor-stripping in Adar Mavs Eif2ak2 Zbp1 mutants shows that loss of blood CD8+ T cells is not prevented. Challenging Adar+/- heterozygous or Adar Mavs Eif2ak2 mice with blood stage Plasmodium yoelii infection led to reduced parasitemia in Adar+/- mice by increased basal interferon. Unexpected reduced parasitemia in Adar Mavs Eif2ak2 mice is also likely due to interferon-related defects specific to hemopoietic cells, leading to altered populations of γδ T cells and other immune cells. The defects observed in this partially dsRNA sensor-stripped mouse suggest that different antiviral dsRNA sensors normally complement each other. - Source: PubMed
Publication date: 2026/05/08
Linhartova PavlaQuin JaclynLoja TomasMelicherova JankaDu QiupeiCherian AnnaVukic DraganaModry DavidTomandlova MarieCervena BarboraStribrnah HelenaOstlund Farrants Ann-KristinKnight AndreaKeegan Liam PeterO'Connell Mary A - Lung transplantation is a definitive lifesaving option for end-stage lung disease; however, its role in rapidly progressive interstitial lung disease (RP-ILD) associated with anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibodies remains debated. We retrospectively analyzed two anti-MDA5-positive RP-ILD (MDA5 RP-ILD) patients who underwent bilateral lung transplantation and synthesized pertinent literature to evaluate clinical value and the impact of therapeutic interventions. Both patients recovered postoperatively and were discharged after symptomatic management and supportive care. One patient subsequently developed cerebral infarction and died approximately 8 months after transplantation, whereas the other remains clinically stable under regular follow-up. Given the limited efficacy of conventional therapies and the overall poor prognosis of anti-MDA5-positive dermatomyositis (MDA5 DM) with RP-ILD, our observations-together with prior reports-support lung transplantation, with extracorporeal membrane oxygenation (ECMO) as a bridge when necessary, as a promising and reliable therapeutic strategy. Lung transplantation may offer definitive treatment in carefully selected patients, underscoring its important clinical value. - Source: PubMed
Publication date: 2026/04/22
Zhang QingLi Xiao-DongLi Yang - The IUCN endangered spotted pond turtle () demonstrates markedly reduced resistance to -induced infections compared to the red-eared slider (). This study investigates the immunological basis for this disparity by analyzing infection outcomes and splenic transcriptomes of both species post-pathogen challenge. In a preliminary experiment, 32 turtles (16 and 16 ) were exposed to . developed skin ulcer syndrome at a significantly higher incidence (81.25%) than (12.5%) ( < 0.05). Comparative transcriptomic analysis identified 19 differentially expressed immune-related genes, with qPCR validation across five tissues (heart, liver, spleen, intestine, blood) revealing pronounced interspecies differences in , , , and expression. Notably, and its downstream effector were robustly upregulated in but were considerably lower in , correlating with delayed pathway activation and impaired epidermal barrier repair. Concurrently, upregulation in facilitated rapid T-cell-mediated pathogen clearance, whereas its delayed induction in hindered adaptive immunity. These findings implicate dysregulated innate () and adaptive () immune pathways as key determinants of 's susceptibility to bacterial infection. Despite the critical conservation status of , the immunological basis underlying its heightened susceptibility to bacterial infections remains largely unexplored; this study addresses this gap by comparing the splenic transcriptomes of and following challenge, identifying the dysregulated - Immune Axis and -mediated adaptive immunity as key determinants, thereby providing actionable immune targets for conservation breeding and susceptibility screening in this endangered species. - Source: PubMed
Publication date: 2026/04/09
Dai WenxiuLi ZeruiLiu YuqingZhou YingwenGan YananYe YinziMu Yi - The development of rapidly progressive interstitial lung disease (RP-ILD) in patients with anti-MDA5-positive dermatomyositis-associated interstitial lung disease (MDA5+ DM-ILD) is a major cause of adverse outcomes, including mortality. This study aimed to identify factors influencing the occurrence of RP-ILD in patients with MDA5+ DM-ILD. - Source: PubMed
Publication date: 2026/04/10
Li HaixiaYi MingyangDa GaoLi MinghaoWang Zhiwan