CLPB
- Known as:
- CLPB
- Catalog number:
- Y213686
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- CLPB
Related genes to: CLPB
- Gene:
- CLPB NIH gene
- Name:
- ClpB homolog, mitochondrial AAA ATPase chaperonin
- Previous symbol:
- -
- Synonyms:
- HSP78, SKD3, FLJ13152, ANKCLB
- Chromosome:
- 11q13.4
- Locus Type:
- gene with protein product
- Date approved:
- 2005-10-04
- Date modifiied:
- 2019-04-23
Related products to: CLPB
anti-CLPBanti-CLPBanti-CLPB type: Primary antibodies host: RabbitAntibody: ClpB-P | ClpB3, Immunogen: KLH-conjugated peptide derived from ClpB-P of Arabidopsis thaliana Q9LF37, Host: rabbit, polyclonal, Confirmed reactivity: Arabidopsis thalianaAntibody: HSP101 | ClpB heat shock protein, C-terminal, Immunogen: recombinant protein of Arabidopsis thaliana Hsp101_ClpB, C-terminal 145 amino acids P42730, Host: rabbit, polyclonal, Confirmed reactAntibody: HSP101 | ClpB heat shock protein, N-terminal, Immunogen: recombinant Arabidopsis thaliana Hsp101_ClpB, N-terminal 145 amino acids P42730, Host: hen, polyclonal, Confirmed reactivity: ArabidoAntibody: HSP101 | ClpB heat shock protein, N-terminal, Immunogen: recombinant Hsp101 N-terminal derived from the sequence of Arabidopsis thaliana Hsp101 protein P42730, Host: rabbit, polyclonal, ConfBos taurus,Bovine,Caseinolytic peptidase B protein homolog,CLPB,SKD3,Suppressor of potassium transport defect 3Bovine Caseinolytic peptidase B protein homolog(CLPB) ELISA kitBovine Caseinolytic peptidase B protein homolog(CLPB) ELISA kitBovine Caseinolytic peptidase B protein homolog(CLPB) ELISA kit SpeciesBovineBovine ClpB caseinolytic peptidase B homolog (E. coli) (CLPB) ELISA kit, Species Bovine, Sample Type serum, plasmaCanine Caseinolytic peptidase B protein homolog(CLPB) ELISA kitCanine Caseinolytic peptidase B protein homolog(CLPB) ELISA kitCaseinolytic peptidase B protein homolog,CLPB,Homo sapiens,HSP78,Human,SKD3,Suppressor of potassium transport defect 3 Related articles to: CLPB
- Lacritin is a tear, saliva, plasma and cerebrospinal fluid glycoprotein with broad polypharmacology. Selective deficiency of its bioactive monomeric form appears to be deleterious for ocular surface health for which replacement therapy is beneficial. Its cleavage-potentiated C-terminus represented by the N-104 proteoform in tears is bactericidal and synergizes with the tear thrombin peptide GKY20. In the pathogenic and multidrug resistant PA14 strain of , we recently discovered that N-104 binds to the outer-membrane lipoprotein YaiW to gain access to the periplasm where it targets and inhibits the inner-membrane ferrous iron transporter FeoB (of FeoABC) as well as PotH, a subunit of the polyamine transporter PotFGHI. Further, PA14 gene expression shifts toward anaerobic respiratory pathways. Here we explore N-104-associated transcriptional changes over a broader range of functional categories pointing to a reduction in: (i) virulence by suppressed gene expression of virulence factors AprA and LasA; and Hcp1 and PsrA necessary for the respective assembly of type VI and III secretion systems, (ii) fitness (less AtsC, MgtA), (iii) metabolism (less AdhA, AtsC, GcvH2, GcvP2, FadE1, SsuD, SsuF, TauB, TauD, UspK, UspN), (iv) stress response (less UnG, PfpI, RmF), (v) proteostasis (less ClpB, GrpE, HtpG), (vii) quorum sensing (less CifR, GcvH2, GcvP2, PsrA, QuiP), and (viii) survival under anaerobic conditions (less AdhA, MhR, ModA, UspKLNO). Upregulated genes are directed towards enhancing PA14: (i) multidrug (more OprJ of MexCD-OprJ) and (ii) tellurite (more TerC) efflux, coupled with a seemingly PA14 survival attempt at (iii) anaerobic respiration (more NosR), (iv) translational fidelity (more QueE, RimP, TrmD) and (v) metabolism (CysT, MoaA1, Sbp, SsuA, SsuE). The overlap with aminoglycosides (4.3%), β-lactams (0%), cyclic peptides (2.5%), fluoroquinilones (0%) and macrolide (1.9%) classes of antibiotics in was minimal. Thus, N-104 appears to widely perturb PA14 fundamental processes in a distinctive manner. - Source: PubMed
Publication date: 2026/03/18
Mohammad Sharifian GhFatemeh NorouziGordon W Laurie - Lead halide perovskites are promising for artificial photosynthesis but suffer from aqueous instability. Here, we stabilize CsPbI quantum dots within a hydrophobic chlorine-functionalized covalent organic framework through multisite atomic-chlorine passivation, forms dual Cl-Pb coordination and Cl-I halogen bonding at the interface. This suppresses ionic migration while creating a gas-solid-liquid triphase interface for enhanced O diffusion. The resulting S-scheme heterojunction spatially separates carriers to concurrently drive two-electron oxygen reduction and water oxidation for HO synthesis without sacrificial agents. The system achieves production rates of 20.37 mmol h g in seawater, with a solar-to-chemical conversion efficiency of 1.38%, and operates stably for 20 h. Importantly, natural sunlight tests yield 11.7 mmol L HO in 10 h. Mechanistic studies confirm synergistic interfacial charge transfer and dual-reaction pathways via both oxygen reduction and water oxidation. This work demonstrates an approach for robust perovskite-based photocatalysts toward solar-driven chemical synthesis from seawater. - Source: PubMed
Publication date: 2026/03/15
Meng GenpingWei ShuaiLi NingYin YuhuiDong BinSun ShihaoHu GuowenWang HaoWang Baodui - The rapid emergence of multidrug-resistant strains of Morganella necessitates new therapeutic approaches, such as phage therapy. Phages are considered a promising adjunct to antibiotics. However, the rapid emergence of phage-resistant bacterial mutants poses a significant challenge in clinical practice. Nevertheless, this phenomenon is often accompanied by fitness trade-offs. Therefore, understanding these fitness trade-offs is crucial prior to phage clinical application. In the present study, a new lytic Morganella morganii phage, named Henu15, was isolated and characterized. The phage genome comprises a 52,795 bp double-stranded DNA with 72 open reading frames. Notably, the phage genome lacks genes encoding integrases, known virulence factors, or acquired antibiotic resistance determinants, underscoring its therapeutic potential. A time-kill assay demonstrated that Henu15 exhibits synergistic effects with ciprofloxacin, norfloxacin, and ceftazidime. Importantly, a Henu15-resistant mutant exhibited pleiotropic defects, including impaired adsorption, enhanced sensitivity to polymyxin B and tetracycline, reduced biofilm formation, and diminished in vivo colonization capacity. Through the whole-genome resequencing of the phage-resistant mutant, mutations were found in 7 genes involved in encoding related proteins such as ATP-dependent chaperone protein ClpB, tetrasulfate reductase subunit A, and AlpA family transcriptional regulators, which might be responsible for the observed fitness defects, providing a molecular basis for the attenuated virulence. Together, these findings provide new insights into the evolutionary interactions between phage resistance and bacterial fitness that could potentially offer a novel approach to treating resistant Morganella infections. - Source: PubMed
Publication date: 2026/03/05
Wang YuhanShen JiawenZhuang HanyueCao HuiruLi JingjingYang XiaoxueLiu FangyuanWang QianXie JiajiaGeng JiayiWang WanerXi YuetingWang XiaoqingLi QimingTeng Tieshan - High-grade ovarian cancer (HGOC) remains a significant therapeutic challenge due to its aggressive nature and poor prognosis. The aim was to elucidate the molecular drivers of HGOC through an integrated bioinformatics analysis. - Source: PubMed
Timirci Kahraman Özlemİnal Gültekin GüldalBillur DeryanazBayralı Ülker Esinİşbilen MuratDurmuş SalihaÇakır TunahanYaylım İlhanİsbir Turgay - The current study investigated the antimicrobial mechanisms of Pulsed Electric Fields (PEF) by evaluating the resistance of 22 Escherichia coli K12 mutants. Initial screening at PEF treatment (23 kV/cm, 53.3 μs, 95.4 kJ/kg), pH 7.0, revealed increased sensitivity (p < 0.05) of ΔclpB, ΔrpoS, and ΔdnaK expressed in Log reductions. Further inactivation kinetic analysis of 8 selected strains at pH 7.0 and 4.0 revealed a non-linear, polyphasic behaviour. This was described by a global modelling approach combining a log-linear primary model with a second-order polynomial model incorporating treatment time, total specific energy, and survival data as variables. The calculated model parameters (C, C, and C) significantly differed (p < 0.05) among strains at pH 7.0, but not at pH 4.0. Furthermore, the calculated inactivation rates, k, varied in relation to the total specific energy. At pH 7.0, k was higher at low (0-40 kJ/kg) and high (140-180 kJ/kg) total specific energies, while at pH 4.0, it raised at high total specific energies (120-160 kJ/kg). In conclusion, E. coli response to PEF was dependant on the stress regulator rpoS. This response also involved genes which encode molecular chaperones such as dnaK, clpB and recA, related proteins for DNA repair. In conclusion, resistance to PEF was found to be influenced by pH and total specific energy, indicating that E. coli mounts a multifaceted response to PEF treatments, informing advanced microbial inactivation strategies for food safety. - Source: PubMed
Publication date: 2026/01/24
Lytras FotiosPsakis GeorgiosGatt RubenRaso JavierValdramidis Vasilis