DGAT1 (Internal)
- Known as:
- DGAT1 (Internal)
- Catalog number:
- Y213653
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- DGAT1 (Internal)
Related genes to: DGAT1 (Internal)
- Gene:
- DGAT1 NIH gene
- Name:
- diacylglycerol O-acyltransferase 1
- Previous symbol:
- DGAT
- Synonyms:
- ARGP1
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-11
- Date modifiied:
- 2017-03-10
Related products to: DGAT1 (Internal)
(I) LightCycler 1. 0; (Internal Control can't be used for this system) ; (II) LightCycler2. 0; (III) PE5700, MJ_Opticon etc. single color systems; (IV) ABI7000, ABI7300, ABI7500, ABI7900, ABI StepO1.0ml Self-Standing Cryovial Internal Thread w/ O-Ring Seal1.2ml Cryogenic Vial,Self-Standing, Internal Thread1.2ml Self-Standing Cryovial Internal Thread w per O-Ring Seal1.2ml Self-Standing Cryovial Internal Thread w per Silicone Wa1.2ml Self-Standing Cryovial Internal Thread w per Washer Seal1.2ml Self-Standing Cryovial Internal Thread w/ O-Ring Seal1.2ml Self-Standing Cryovial Internal Thread w/ O-Ring Seal1.2ml Self-Standing Cryovial Internal Thread w/ Silicone Wa1.2ml Self-Standing Cryovial Internal Thread w/ Silicone Wa1.2ml Self-Standing Cryovial Internal Thread w/Washer Seal1.2ml Self-Standing Cryovial Internal Thread w/Washer Seal1.2ml Self-Standing Cryovial Internal Thread w_ O-Ring Seal1.2ml Self-Standing Cryovial Internal Thread w_ Silicone Wa1.5-times expansion model of ear dissection, external, middle & internal ear, 4 parts Related articles to: DGAT1 (Internal)
- The potential role of diacylglycerol acyltransferase 1(DGAT1) in regulating dendritic cell (DC) function and apoptosis in sepsis and its associated mechanisms is still unknown. Levels of very low-density lipoproteins (VLDLs), which transport endogenous triglycerides, are elevated in sepsis, leading to hypertriglyceridemia. Triacylglyceride (triacylglycerol, TAG) is the main energy storage material in life. DGAT 1 is a key enzyme in triglyceride synthesis, responsible for TAG synthesis during fat absorption and storage. This study explored the effect of the regulation of DGAT 1 expression on the immune function of dendritic cells in sepsis and associated mechanisms. Downregulation of DGAT 1 expression improved the function and apoptosis of bone marrow-derived dendritic cells in sepsis and may have activated pathway signaling proteins (JAK 2 and STAT 3) to alleviate oxidative stress and inflammation. These suggest that DGAT 1 may have a role in improving immune function in sepsis. - Source: PubMed
Publication date: 2026/04/17
Zhang MinZhang YaoluWu FangfangChen JianmingSu XiayiTao ZhangbinLi KeYe JianpingLu Zhongqiu - Aberrant interplay between epigenetics and metabolism contributes to prostate cancer (PCa) progression and represents a formidable challenge limiting the efficacy of drugs. Elucidation of the epigenetic underpinnings of prostate cancer (PCa) could provide promising insights into the drivers of therapy resistance. Through an unbiased siRNA screen of mSWI/SNF family members, which play a significant role in tumorigenesis, we identified Bromodomain containing 9 (BRD9) as an essential gene for PCa growth. Targeting BRD9 abolished PCa colony formation and migration in vitro, and inhibited orthotopic tumor growth in vivo. YAP/TEAD4 complex bound to the BRD9 promoter to elevate its levels. Integrated CUT&Tag-seq and RNA-seq analyses revealed DGAT1 as an important BRD9 effector. Mechanistically, BRD9 interacted with SREBP1 to co-occupy the DGAT1 promoter, increasing the H3K4me3 enrichment and chromatin accessibility. Additionally, the YAP-BRD9 axis enhanced the lipid droplets (LDs) formation, ferroptosis resistance, and tumorigenesis via inducing DGAT1. The pharmacological inhibition (or depletion) of BRD9 suppressed LDs formation, restored ferroptosis sensitivity, and PCa malignancy. Overall, the BRD9-SREBP1-DGAT1 axis represents a potential epigenetic therapeutic target for YAP-high PCa. - Source: PubMed
Publication date: 2026/04/14
Zhu XuejinWen ZhimeiWu JinhaiChen SianXu RanWang BinZhu YingwenChen Yanfei - This experiment investigated the effects of dietary Krasch. (AOK) supplementation on the n3-polyunsaturated fatty acid (n3-PUFA) profile of subcutaneous adipose tissue (SADT) in Arbas cashmere goats and explored the underlying transcriptional mechanisms. Forty healthy, weaned kids (120 ± 10 days of age; similar body weight) were randomly allocated to two groups ( = 20): a control group (CON, basal diet) and an AOK group (AOK, basal diet with 3% of the roughage replaced by AOK). The feeding trial spanned 104 days, consisting of a 14-day adaptation period and 90 days of data acquisition. Compared with the CON group, AOK significantly reduced the content of saturated fatty acids (SFAs) and n6-polyunsaturated fatty acids (n6-PUFAs)/n3-PUFAs (n6/n3). In contrast, the levels of n3-PUFAs in the SADT of cashmere goats increased markedly ( < 0.05). Compared with the CON group, AOK exhibited significantly higher activities of hormone-sensitive lipase (HSL) ( = 0.027), adenylyl cyclase 2 (ADCY2) ( = 0.010), adenylyl cyclase 5 (ADCY5) ( = 0.046), cluster of differentiation 36 (CD36) ( = 0.013), solute carrier family 27 member 4 (SLC27A4) ( = 0.021), and fatty acid binding protein 4 (FABP4) ( = 0.040), along with significantly lower activities of fatty acid synthase (FAS) ( = 0.002), lipoprotein lipase (LPL) ( = 0.048), and stearoyl-coa desaturase (SCD) ( = 0.026) in SADT. Compared with the CON group, the activities of superoxide dismutase (SOD) ( = 0.032), catalase (CAT) ( = 0.010), glutathione peroxidase (GSH-PX) ( = 0.029), and total antioxidant capacity (T-AOC) ( = 0.002) were significantly increased in the AOK group. Transcriptomic profiling revealed that AOK supplementation downregulated mRNA levels of , 5, , , , 1 (1), stearoyl- 2 (2), 1 (1), 1 (1), (), 1 (1), 1 (1), 27 2 (272), 4 (4), and 1 (1) ( < 0.05). It also markedly induced 4 (4) ( < 0.01) in SADT. Genes significantly enriched in the adenosine-monophosphate-activated protein kinase (AMPK) signaling pathway included , 1, 1, and 1 ( = 0.010). Genes significantly enriched in the phosphatidylinositol 3-kinase-akt (PI3K-Akt) signaling pathway included 1 and 4 ( = 0.015). 1, 2, and 1 were identified as the genes significantly enriched in the insulin resistance signaling pathway ( = 0.048). was the only gene significantly enriched in the cholesterol metabolism pathway ( = 0.049). Genes showing a tendency toward significant enrichment in the peroxisome-proliferator-activated receptor (PPAR) signaling pathway included 4, 1, 1, and ( = 0.051). These interconnected cascades improve insulin sensitivity, stimulate triglyceride (TG) hydrolysis, and modulate n3-PUFA levels. Supplementation with AOK enhances n3-PUFA content by accelerating TG breakdown while simultaneously restraining FA oxidation in SADT. Consequently, AOK supplementation can be effectively used to enhance the nutritional value of cashmere goat meat through improved n3-PUFA deposition in SADT. - Source: PubMed
Publication date: 2026/04/02
Jiang LianguangZhao YanliZhang QingyueZhang ShangxiongGuo XiaoyuGuo YongmeiYan Sumei - The Crimean-Congo Haemorrhagic Fever Virus (CCHFV), a tri-segmented negative-strand virus that belongs to the genus, is highly pathogenic in humans but not in other host species. Following infection in humans, CCHFV disseminates widely but replicates most strongly in hepatocytes, indicating a preferential liver tropism. As hepatocytes are the primary site for production and secretion of lipids, here we sought to characterize the interplay between CCHFV and lipoprotein metabolism in hepatocytes. First, we found that CCHFV particles display a heterogeneous profile of density, suggesting various virion compositions. Next, we showed that several lipoprotein components are associated with viral particles. Additionally, we found that pharmacological inhibition or down-regulation of the host factors involved in lipoprotein biogenesis and lipid metabolism could impair CCHFV infection. Our results, therefore, by revealing a close interplay between liver lipid metabolism and CCHFV, highlight the potential of repurposing existing lipid-modulating drugs and allow designing new interventions to curb CCHFV infections. - Source: PubMed
Publication date: 2026/03/30
Gautam AnupriyaZhong LiOgire EvaBodoirat SergueïRiedmiller IlarySander Willem JBoson BertrandGandhi ApoorvBurlaud-Gaillard JulienAmirache FouziaLegros VincentRoingeard PhilippeLotteau VincentMathieu CyrilleCosset François-LoïcDenolly Solène - Pregnancy requires coordinated immunometabolic adaptations that allow maternal immune tolerance while preserving tissue remodeling and host defense. Circulating monocytes contribute critically to these processes, yet how gestation shapes their metabolic state and functional specialization remains incompletely defined. - Source: PubMed
Publication date: 2026/03/06
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