FADS1
- Known as:
- FADS1
- Catalog number:
- Y213651
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- FADS1
Related genes to: FADS1
- Gene:
- FADS1 NIH gene
- Name:
- fatty acid desaturase 1
- Previous symbol:
- LLCDL1
- Synonyms:
- D5D, FADSD5, TU12, FADS6
- Chromosome:
- 11q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-30
- Date modifiied:
- 2016-10-05
Related products to: FADS1
Related articles to: FADS1
- The Zhuang, China's largest ethnic minority with over 17 million individuals, represent a critical yet understudied population for understanding East Asian genetic diversity and population history. Here, we present the first high-coverage whole-genome (>30×) and exome (>70×) sequencing study of the Zhuang (ZUN), integrating ancient and modern genomic data to reconstruct their evolutionary trajectory. We show that ZUN derive ∼68% of their ancestry from the Tai-Kadai-speaking people, diverging ∼3,000-5,000 years ago (ya), with the Maonan as their closest genetic relatives. Our analyses support a shared origin of Tai-Kadai and Austronesian populations ∼7,000 ya, predating their divergence from Sino-Tibetan groups ∼16,000 ya. Substantial gene flow from Han Chinese since ∼4,000 ya reduced genetic divergence between ZUN and northern East Asians to ∼12,000 years. The ZUN ancestral gene pool formed ∼5,000-3,000 ya through multiple admixture waves, with 87% contribution from southern populations and 12% from northern groups. Demographic modeling indicates continuous population expansion until ∼10,000 ya, followed by a pronounced growth surge over the past 400 years. Adaptive selection signatures highlight genes linked to immune response (IGH cluster), lipid metabolism (FADS1/2), wound healing (TMEM121), and environmental adaptation (ABCC11), suggesting dietary shifts and tropical pathogens as key evolutionary drivers. Furthermore, the ZUN genetic profile reflects their role as a regional hub for gene flow into neighboring populations, coinciding with Han migrations during the Qin dynasty. Together, these results identify the Zhuang as descendants of Baiyue populations with a distinctive dual ancestry shaped by Neolithic southern and northern East Asians. - Source: PubMed
Publication date: 2026/05/15
Mao ChuangxueLi SongyangLu YanLiu QiDeng LianGao YangZhang XiaoxiChen HaoYang YajunXu Shuhua - Type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD) frequently coexist and increase cardiovascular risk. Although habitual omega-3 (ω3) polyunsaturated fatty acids (PUFAs) may improve cardiovascular risk, their metabolic effects in type 2 diabetes and MASLD remain unclear. We hypothesized that ω3-PUFA intake reduces hepatocellular lipid content (HCL) in individuals carrying single-nucleotide polymorphisms (SNPs) of the fatty acid desaturase (FADS) 1 and FADS2 genes, which associate with higher desaturase activity. - Source: PubMed
Publication date: 2026/05/02
Suzuki KeitaBódis Kálmán BPafili KalliopiHara AkinoriKnebel BirgitSchlesinger SabrinaSchrauwen-Hinderling VeraTrenkamp SandraAl-Hasani HadiKahl SabineHerder ChristianWagner RobertTakamura ToshinariNakamura HiroyukiRoden Michael - Gout is an acute inflammatory arthritis triggered by monosodium urate (MSU) crystal deposition and activation of innate immune responses. In addition to inflammasome signaling, emerging evidence suggests that metabolic reprogramming of arachidonic acid (AA) pathways amplifies inflammatory responses during gout flares. However, the contribution of upstream fatty acid desaturation processes that regulate endogenous AA availability remains poorly defined. 1,2,3,4,6-Penta-O-galloyl-β-D-glucose (PGG) is a naturally occurring polyphenol with reported anti-inflammatory activity, but its effects on MSU-induced fatty acid metabolism and gouty inflammation have not been well established. - Source: PubMed
Publication date: 2026/04/24
Umar SadiqLu YuDhavamani SugasiniYalagala Poorna C RWietecha Mateusz SRavindran Sriram - Benzo(a)pyrene (BaP) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), as typical environmental carcinogens, are widely present in tobacco smoke and air pollution. Their combined exposure is an important cause of high incidence of laryngeal cancer. However, the molecular mechanism of their synergistic carcinogenesis remains unclear. To fill this gap, this study employed an integrated strategy combining network toxicology, multi-dimensional transcriptomics (bulk and single-cell), machine learning, molecular simulation, and cell function verification to systematically explore the mechanism by which BaP and NNK combined exposure induce laryngeal cancer. Through multi-dimensional data mining and machine learning algorithms, the core molecule FADS1 was identified. Functional enrichment analysis revealed that FADS1-related genes mainly participate in lipid metabolism reprogramming and tumor malignant phenotype regulation pathways. Molecular docking and 100 ns kinetic simulation confirmed that both BaP and NNK can stably bind to FADS1, with a stronger binding affinity for BaP (ΔG = -9.0 kilocalories/mole), and the binding mode is mainly based on van der Waals forces and hydrophobic interactions. Cell experiments demonstrated that combined exposure of BaP and NNK can significantly upregulate the expression of FADS1 in laryngeal cancer cells, enhance cell proliferation, migration, and invasion abilities, while silencing FADS1 can effectively reverse these malignant phenotypes. In summary, this study clarified the key role of FADS1 in mediating the synergistic promotion of laryngeal cancer by BaP/NNK, providing experimental support for understanding the carcinogenic mechanism of environmental compound pollutants, and also offering potential targets for risk assessment, early diagnosis, and precise prevention and control of air pollution and tobacco exposure-related laryngeal cancer. - Source: PubMed
Publication date: 2026/05/08
Hu YifanHe ZhizhenLi ShuangHan BaoaiYang XiupingChen Xiong - During the European Neolithic transition, migrating Anatolian farmers admixed with local hunter-gatherers, coinciding with major shifts in diet, environment, and lifestyle that imposed strong selective pressures. Local ancestry inference is widely used to detect selection following admixture, but most methods were developed and validated on present-day populations. Their performance in ancient DNA, where reference panels are smaller, data sparser, and admixture more ancient, remains unresolved. We benchmark six local ancestry inference methods on 176 imputed Neolithic genomes, comparing ancestry proportions, tract length distributions, and selection signatures. While individual-level ancestry estimates are highly correlated across methods, inferred tract lengths and admixture time estimates vary by over an order of magnitude. Integrating results across methods and replicating across methods and in two independent datasets (n=378 and 1,121) identifies robust ancestry deviations at and , consistent with adaptation on pigmentation and metabolism, respectively. We also identify (circadian rhythm) and (innate immunity) as candidate loci, but with less consistent signals across methods. Finally, we replicate previous reports of excess hunter-gatherer ancestry at the HLA, but these results are inconsistent across methods and suggest that they may be affected by bias in local ancestry inference. Our findings demonstrate that while local ancestry inference recovers biologically meaningful signals in ancient genomes, results can be sensitive to the methods used for inference, particularly in complex regions like the HLA. Method choice critically influences inferred ancestry patterns and selection signals, underscoring the importance of multi-method validation. - Source: PubMed
Publication date: 2026/04/28
Mies GeorgiaMathieson Iain