LAG3
- Known as:
- LAG3
- Catalog number:
- Y213646
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- LAG3
Related genes to: LAG3
- Gene:
- LAG3 NIH gene
- Name:
- lymphocyte activating 3
- Previous symbol:
- -
- Synonyms:
- CD223
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-03
- Date modifiied:
- 2016-10-05
Related products to: LAG3
Related articles to: LAG3
- Natural killer (NK) cells play a central role in anti-tumor immunity and immunosurveillance of senescence, yet their clinical performance is frequently limited by functional exhaustion during ex vivo expansion. Mesenchymal stem cell-derived exosomes (MSC-Exos) are increasingly recognized as immunomodulators, but their broader effects on NK cell fitness and functional states remain incompletely characterized. - Source: PubMed
Publication date: 2026/04/20
Fu YunyunLiu YiXu MingwenLiu GaojunSun JianzhiBu FanyuXie WenqingZhao JiayiLuo JunGuo QiangHuang YinghuaXu FengpingLiu SiqiLiu LongqiFu YingDong Xuan - Colon cancer (CC), a malignancy with high global incidence and mortality, remains a major public health burden. As a pivotal aspect of tumor metabolic reprogramming, fatty acid metabolism has drawn significant research interest. This study was designed to elucidate the relationship between fatty acid metabolism-related gene expression and prognosis in patients with CC. - Source: PubMed
Publication date: 2026/03/15
Zhou ShulingChen MinDong ZhikunYang YongShi XiaoruiKang HuanShi ChangbeiWang Xuan - Infusion-related reactions (IRRs) to immune checkpoint inhibitors (ICIs) have been reported in up to 20% of administrations, but the incidence varies among ICIs. - Source: PubMed
Publication date: 2026/04/17
Fujiwara YuTakahashi ToshiakiTsuchiya KazuyaKoseki MakoMarkus AnnelieseElias EvelynNishimura YoshitoPuzanov Igor - A 52-year-old man presented with sarcomatoid diffuse pleural mesothelioma that had relapsed at an isolated site after a complete response to dual-immune checkpoint inhibition (ICI). Targeted sequencing exhibited amplification of chromosome 9p24, encompassing JAK2, PD-L1, PD-L2, and PTPRD in the relapsed (post-ICI) tumor, compared with baseline (pre-ICI). On multiplex immunofluorescence, tumor-associated macrophages (TAMs) and CD8 cytotoxic T lymphocytes (CTLs) made up most of the cells in baseline and relapsed tumor (59% and 47%, respectively). Baseline tumor cells expressed genes linked to extracellular matrix remodeling and epithelial-mesenchymal transition, intermixed with M2-like TAMs and tissue-resident, effector-like CTLs. Relapsed tumor cells shifted to a growth factor-driven phenotype (NT5E, NOD1, GATA2, FN1, PDCD1LG2) that is known to cause functional impairment of CTLs, which then transitioned to an exhausted state (FCRL3, CST7, GPR171, TRAT1, LAG3); exhausted CD8 and CD4 T cells are seen in the peripheral blood at relapse. TAMs were enriched in antigen-presentation (CD80, CD86, CXCL10), extracellular matrix-degradation (MMP9, CTSL), and CTL-suppression (ARG1, PLA2G7) pathways. Our analyses revealed that regional immunosuppression mediated by adaptive reprogramming of tumor-cell and immune-cell (TAMs, CTLs)-intrinsic changes-rather than by immune evasion or stromal exclusion-served as a mechanism of acquired resistance to dual-ICI therapy. - Source: PubMed
Publication date: 2026/04/15
Ollila HelyKulkarni PrateekKim HyojinAnkola PratitiChintala Navin KThomas CarlosSauter Jennifer LOffin MichaelAdusumilli Prasad S - Continuous exposure to antigens drives the activation of circulating T follicular helper (cTfh) cells, promoting high-affinity antibody production. However, sustained stimulation may impair their function through the upregulation of immunoregulatory markers like B and T lymphocyte attenuator (BTLA) and Lymphocyte-activation gene 3 (LAG-3). This study investigated the role of cTfh cells and their subsets in Plasmodium falciparum-associated placental malaria (PM). In a cross-sectional study conducted in Yaounde, Cameroon (March 2022-May 2023), peripheral, placental, and cord blood samples were collected from 49 women at delivery. Hemoglobin (Hb) levels were recorded, and peripheral blood mononuclear cells (PBMCs), intervillous blood mononuclear cell (IVBMCs), and cord blood mononuclear cells (CBMCs) were isolated for multiparametric flow cytometry analysis of cTfh cells and subsets (ICOS and ICOS cTfh subsets). PM was associated with increased cTfh cell frequencies in both PBMC and IVBMC. PM-negative (PM-) women displayed higher ICOS cTfh cell frequencies, while PM-positive (PM+) women had elevated ICOS cTfh cells that correlated with parasitemia levels. BTLA expression was downregulated in bulk cTfh and ICOS cTfh cells during PM. Interestingly, cTfh frequencies in IVBMC positively correlated with baby weight, while cTfh frequencies in PBMC and IVBMC negatively associated with maternal Hb. Furthermore, BTLA and LAG-3 expression in IVBMC negatively correlated with birth weight. Together, these findings highlight altered cTfh cell profiles during PM, influencing maternal and neonatal outcomes. - Source: PubMed
Zambo Bitye Bernard MarieMbianda Nana Chris MarcoKwanou Tchakounte Bodin DarcisseFogang BalotinKenfack Tekougang Zangue BereniceMedouen Ndeumou Reine Seumko'oAyong LawrenceMegnekou Rosette