S100A4 _ CAPL
- Known as:
- S100A4 _ CAPL
- Catalog number:
- Y213614
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- S100A4 _ CAPL
Related genes to: S100A4 _ CAPL
- Gene:
- S100A4 NIH gene
- Name:
- S100 calcium binding protein A4
- Previous symbol:
- MTS1, CAPL
- Synonyms:
- P9KA, 18A2, PEL98, 42A, FSP1
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2018-05-02
Related products to: S100A4 _ CAPL
Related articles to: S100A4 _ CAPL
- Non-alcoholic fatty liver disease (NAFLD) is a globally prevalent chronic liver disease, and its progression is closely associated with Kupffer cells (KCs). This study aims to characterize C-X-C motif chemokine ligand 9꞉secreted phosphoprotein 1 (CS) polarization in KCs and investigate its intercellular communication with endothelial cells (ECs) in NAFLD. - Source: PubMed
Lu YaoNi WenjuanChen RongcuiWang Wei - The aim was to determine the transcriptomic features of tumor and stromal cells in direct contact within tumor nodules in luminal and triple-negative breast cancer. - Source: PubMed
Publication date: 2026/07/29
Kalinchuk Anna YuPatskan Ivan AGrigorieva Evgeniya STashireva Liubov A - The search for new regulators of the immune response is an important task of modern immunology. In this work, we have found that Mts1 binds with high specificity to the innate immunity receptor TREM-1 and forms a stable complex with it. The same complex was found on the cell surface of macrophages. The appearance of soluble sTREM-1 in a conditioned medium after Mts1 interaction is considered the starting point of receptor activation. PCR analysis indicates activation of proinflammatory genes IL6, IL1β, and TNF after Mts1 administration. Based on these results, Mts1 can be considered a novel TREM-1 ligand. Using limited trypsinolisis, we have identified the epitopes of Mts1 responsible for TREM-1 activation. Similar to the full-length protein Mts1, the 17aa М7 peptide (ELPSFLGKRTDEAAFQK) of the Mts1 protein activates the TREM-1 receptor. Incubation of human lymphocytes with the Mts1 protein of its M7 peptide results in the appearance of cytotoxic subpopulations of NK cells and T lymphocytes, able to lyse HLA-deficient cancer cells via apoptosis or necroptosis. Activated lymphocytes induce apoptosis and necroptosis in HLA-negative tumor cells. The new regulatory peptide may be potentially used for the regulation of inflammatory processes and activation of antitumor immunity. - Source: PubMed
Publication date: 2026/07/17
Zhelezova Daria MRomanova Elena ATvorogova Anna VZiganshin Rustam HYashin Denis VSashchenko Lidia P - Glioblastoma multiforme (GBM) is among the most aggressive malignant brain tumors and is characterized by severe infiltration into surrounding brain tissue, rendering early detection exceedingly difficult with current diagnostic imaging methods. Chosen biomarkers S100A4, with a role in cell motility and tumor metastasis, and midkine (MDK), connected to tumor microenvironment remodeling and expansion, are both linked to GBM's infiltrative proliferation. This study investigates a computational framework for the structure-guided design of DNA tweezer nanostructures, evaluated for predicted interactions with S100A4 and MDK. AlphaFold 3 modeling predicted the three-dimensional structures of eight three-stranded, hinge-scaffolded DNA tweezer candidates. DNA structures and target proteins were paired together in molecular docking simulations conducted with HDOCK, from which docking analyses predicted favorable binding arrangements of the complexes identified. Among the constructs investigated, DT3_8 exhibited the most favorable predicted interaction profile across the integrated computational analyses. Comparative docking against additional S100 family proteins with similar electrostatic characteristics further suggested that the predicted interaction profile of DT3_8 may not be explained solely by nonspecific electrostatic complementarity. Collectively, these findings provide a computational proof of concept for the design of dual-target DNA tweezer nanostructures and establish a foundation for future development and experimental evaluation of DNA-based biosensing platforms for glioblastoma-associated biomarkers. - Source: PubMed
Publication date: 2026/07/20
Foo Hayley - Ectopic pancreas is defined as pancreatic tissue lacking anatomical and vascular continuity with the main pancreas. Malignant transformation within ectopic pancreatic tissue is extremely rare, and cases arising in the mesentery are exceptionally uncommon. We report a rare case of adenocarcinoma arising from ectopic pancreatic tissue in the proximal jejunal mesentery. - Source: PubMed
Publication date: 2026/07/17
Furusho IzuruHirashita TeijiroMiyoshino WataruTakayama HiroomiKawano YokoNagasawa YuikoNakamura ShunKawamura MasahiroMasuda TakashiEndo YuichiDaa TsutomuInomata Masafumi