Serotonin receptor 3A _ HTR3A

Price:

668.80 €

Known as:: Serotonin receptor 3A _ HTR3A
Catalog number:: Y213578
Product Quantity:: 200ul
Category:: -
Supplier:: ABM
Gene target:: Serotonin receptor 3A _ HTR3A

Related genes to: Serotonin receptor 3A _ HTR3A

Gene:: HTR3A ^{NIH gene}
Name:: 5-hydroxytryptamine receptor 3A
Previous symbol:: HTR3
Synonyms:: 5-HT3R, 5-HT3A
Chromosome:: 11q23.2
Locus Type:: gene with protein product
Date approved:: 1994-06-16
Date modifiied:: 2016-10-11

Related products to: Serotonin receptor 3A _ HTR3A

Related articles to: Serotonin receptor 3A _ HTR3A

Boldine Mitigates Chronic Unpredictable Stress-Induced Depression by Suppressing Serotonin 3A Receptor-Calcium/Calmodulin-Dependent Protein Kinase II Signaling and Nucleotide-Binding Domain Leucine-Rich Repeat Protein 3 Inflammasome in the Hippocampus.
Major depressive disorder is a debilitating condition linked to dysregulated serotonin (5-HT) signaling, neuroinflammation, and oxidative stress. Boldine (BDN), a natural aporphine alkaloid with antioxidant and neuroprotective properties, might have antidepressant potential, which is still unexplored. This study investigates the effects of BDN on chronic unpredictable stress (CUS)-induced depression-like behavior in male Wistar rats. It focuses on neuroinflammation, oxidative stress, monoamine levels, and 5-HT receptor modulation. Rats were subjected to CUS for 42 days and treated with BDN (20, 40, or 80 mg/kg, po) or vortioxetine (VORT, 20 mg/kg, p.o) from the 22nd to 42nd day. Behavioral assessments (sucrose preference test, forced swim test, hole board test) revealed that BDN significantly alleviated anhedonia, despair, and anxiety-like behaviors. CUS increased serum and hippocampal cortisol, oxidative stress (elevated malondialdehyde, reduced glutathione, superoxide dismutase, catalase), and pro-inflammatory markers (NLRP3, IL-1β), which BDN effectively normalized. High-performance liquid chromatographic analysis of the brain region showed that BDN restored hippocampal dopamine, norepinephrine, and serotonin levels. RT-PCR analysis demonstrated that BDN downregulated hippocampal and upregulated gene expression, suggesting serotonergic modulation. Histopathological evaluation confirmed BDN neuroprotective effects preventing CUS-induced neuronal damage in the CA1 and CA3 hippocampal regions. These findings indicate that BDN exerts antidepressant effects by mitigating oxidative stress, suppressing NLRP3-mediated neuroinflammation, normalizing HPA axis hyperactivity, and modulating 5-HT receptor signaling. Thus, BDN represents a promising multitarget therapeutic candidate for stress-related depression. - Source: PubMed
Publication date: 2026/04/28
Akotkar LikhitAswar Urmila
ANKFN1 in skin fibroblasts may modulate mast cell activity and is associated with dupilumab response in atopic dermatitis.
Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease. Dupilumab is a new targeted drug used to treat moderate to severe AD. However, some patients with AD exhibit poor response to dupilumab treatment. - Source: PubMed
Publication date: 2026/05/01
Wei Qiu-JuLu Jia-RongXiang Wan-YanLiang Hai-QiZhang Si-QiHuang Si-YuPeng Jun-WenZhou Ze-FengLi Qiu-JuZheng Wen-Jun
Fecal microbiota transplantation and Akkermansia muciniphila restore neurodevelopment and behavior via the gut-brain axis in autism-like zebrafish.
Effective therapies for Autism Spectrum Disorder (ASD) are currently limited, and the functional connections between gut microbiota and brain development are not fully elucidated. Using the Katnal2 mutant zebrafish as an ASD-like model, we evaluated whether fecal microbiota transplantation (FMT) from wild-type donors or supplementation with the probiotic Akkermansia muciniphila (A. muciniphila) could ameliorate neurodevelopmental deficits. Assessments included developmental phenotypes, behavior, microbial profiling, neurotransmitter-related gene expression, and short-chain fatty acid (SCFA) signaling in conventionally reared (CR) and germ-free (GF) fish. FMT from wild-type donors and A. muciniphila supplementation significantly improved hatching rates, growth parameters, heart rate, and locomotor activity in Katnal2 mutants, whereas microbiota from Katnal2 mutants induced analogous deficits in wild-type recipients. A. muciniphila successfully colonized the gut, reshaped microbial communities, and reduced anxiety-like behaviors. Mechanistically, A. muciniphila upregulates genes involved in dopamine (th), serotonin (tph1a), and gamma-aminobutyric acid (GABA) synthesis, downregulates the serotonin receptor htr3a, and enhances expression of the SCFA receptor ffar2, independently of total SCFA levels. Correlation analyses linked key developmental, behavioral, and transcriptional changes to altered microbial genera in a sample-specific manner, highlighting compositionally driven neuromodulatory effects of genetic and probiotic interventions. Thus, microbiota-targeted intervention with A. muciniphila rescues neurodevelopmental impairments in ASD models by remodeling the gut-brain axis, supporting its translational potential. - Source: PubMed
Jia Pan-PanLi YanYang Hao-YuDing YuanGuo Feng-YiWu Ming-FeiJia Jin-QiuPei De-Sheng
Differential Expression of Endocannabinoid Receptors in Lesional and Non-Lesional Skin of Psoriasis Patients: Insights Into Pathogenesis and Potential Therapeutic Targets.
Psoriasis is a chronic, immune-mediated inflammatory skin disease with a complex etiology involving genetics, environmental triggers, and immune dysregulation. Research suggests that the endocannabinoid system (ECS) is involved in inflammation and skin homeostasis, prompting interest in its involvement in the pathogenesis of psoriasis. - Source: PubMed
Publication date: 2025/07/26
Turk Jaime NKirchhof Mark G
Identification and expression profile of serotonin receptors in the developmental stages and hemocytes of the Pacific oyster (Crassostrea gigas).
Serotonin (5-hydroxytryptamine, 5-HT), a pleiotropic biogenic monoamine, modulates immune response through interactions with its distinct receptors (5-HTRs). In this study, thirteen 5-HTRs were identified in the Pacific oyster (Crassostrea gigas) to elucidate their functions in immune response to Vibrio stimulation. Except for the unique ligand-gated cation channels (Cg5-HTR3A-like), the other twelve 5-HTRs (Two Cg5-HTR, Cg5-HTR-like, Cg5-HTR1, Cg5-HTR1A-like, Cg5-HTR1B, Cg5-HTR1B-like, Cg5-HTR2A-like, Cg5-HTR2B, Cg5-HTR4, Cg5-HTR5, and Cg5-HTR6) all belong to G protein-coupled receptor (GPCR) superfamily. Among those twelve 5-HTRs, most are non-canonical members lacking complete seven-transmembrane (7TM) domains; only Cg5-HTR2B and Cg5-HTR6 retain the canonical GPCR architecture. Ten conserved motifs were identified in oyster 5-HTRs, with motif 2 being universal across all receptors and motif 10 unique to Cg5-HTR3A-like, indicating subtype-specific divergence. Molecular docking revealed significant differences in binding affinity and residue interaction among Cg5-HTRs, with Cg5-HTR6 exhibiting the highest binding affinity for 5-HT. Analysis across developmental stages revealed that Cg5-HTR1A-like transcripts were enriched in early gastrula, gastrula and trochophore, Cg5-HTR4, Cg5-HTR1B, and Cg5-HTR-like enriched specifically in the D-shape stage, while Cg5-HTR2B and Cg5-HTR1 transcripts enriched during the pediveliger, spat, and juvenile stages. Furthermore, Cg5-HTR-like and Cg5-HTR1 were primarily expressed in granulocytes, Cg5-HTR1A-like and Cg5-HTR2B in agranulocytes, and Cg5-HTR6 and Cg5-HTR1B in semi-granulocytes. Crucially, following secondary Vibrio splendidus stimulation, the expression levels of Cg5-HTR-like, Cg5-HTR1, Cg5-HTR1A-like, Cg5-HTR1B and Cg5-HTR2B mRNA in hemocytes upregulated significantly, indicating their potential role in immune priming. These findings suggested the potential mechanisms of 5-HTRs in regulating the immune response of hemocytes in C. gigas, which offered insights into the evolutionary conservation and immunoregulation divergence of these receptors in invertebrates. - Source: PubMed
Publication date: 2026/01/31
Xu MinhuiDong MirenGao XiaolongWu WeiWang LinglingWang Chunlin

Serotonin receptor 3A _ HTR3A

Related genes to: Serotonin receptor 3A _ HTR3A

Related products to: Serotonin receptor 3A _ HTR3A

Related articles to: Serotonin receptor 3A _ HTR3A

Boldine Mitigates Chronic Unpredictable Stress-Induced Depression by Suppressing Serotonin 3A Receptor-Calcium/Calmodulin-Dependent Protein Kinase II Signaling and Nucleotide-Binding Domain Leucine-Rich Repeat Protein 3 Inflammasome in the Hippocampus.

ANKFN1 in skin fibroblasts may modulate mast cell activity and is associated with dupilumab response in atopic dermatitis.

Fecal microbiota transplantation and Akkermansia muciniphila restore neurodevelopment and behavior via the gut-brain axis in autism-like zebrafish.

Differential Expression of Endocannabinoid Receptors in Lesional and Non-Lesional Skin of Psoriasis Patients: Insights Into Pathogenesis and Potential Therapeutic Targets.

Identification and expression profile of serotonin receptors in the developmental stages and hemocytes of the Pacific oyster (Crassostrea gigas).