CYP17A1
- Known as:
- CYP17A1
- Catalog number:
- Y213528
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- CYP17A1
Related genes to: CYP17A1
- Gene:
- CYP17A1 NIH gene
- Name:
- cytochrome P450 family 17 subfamily A member 1
- Previous symbol:
- CYP17
- Synonyms:
- P450C17, CPT7, S17AH
- Chromosome:
- 10q24.32
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2017-12-15
- Gene:
- CYP17A1-AS1 NIH gene
- Name:
- CYP17A1 antisense RNA 1
- Previous symbol:
- CYP17A1OS
- Synonyms:
- bA753C18.3
- Chromosome:
- 10q24.32
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2004-05-27
- Date modifiied:
- 2015-07-09
Related products to: CYP17A1
Antibodies: CYP17A1 HOST: Goat Clonality: pAbBovine cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1) ELISA kit, Species Bovine, Sample Type serum, plasmaBovine Steroid 17-alpha-hydroxylase per 17,20 lyase;Cytochrome P450 17A1,CYP17A1 ELISA KitBovine Steroid 17-alpha-hydroxylase per 17,20 lyase;Cytochrome P450 17A1,CYP17A1 ELISA KitBovine Steroid 17-alpha-hydroxylase-17,20 lyase;Cytochrome P450 17A1,CYP17A1 ELISA KitBovine Steroid 17-alpha-hydroxylase-17,20 lyase;Cytochrome P450 17A1,CYP17A1 ELISA KitBovine Steroid 17-alpha-hydroxylase-17,20 lyase;Cytochrome P450 17A1,CYP17A1 ELISA KitBovine Steroid 17-alpha-hydroxylase-17,20 lyase;Cytochrome P450 17A1,CYP17A1 ELISA KitBovine Steroid 17-alpha-hydroxylase/17,20 lyase(CYP17A1) ELISA kitBovine Steroid 17-alpha-hydroxylase/17,20 lyase;Cytochrome P450 17A1,CYP17A1 ELISA KitBovine Steroid 17-alpha-hydroxylase/17,20 lyase;Cytochrome P450 17A1,CYP17A1 ELISA KitBovine Steroid 17-alpha-hydroxylase/17,20 lyase;Cytochrome P450 17A1,CYP17A1 ELISA KitBovine Steroid 17-alpha-hydroxylase/17,20 lyase;Cytochrome P450 17A1,CYP17A1 ELISA KitBovine Steroid 17-alpha-hydroxylase/17,20 lyase;Cytochrome P450 17A1,CYP17A1 ELISA KitBovine Steroid 17-alpha-hydroxylase_17,20 lyase(CYP17A1) ELISA kit Related articles to: CYP17A1
- Approximately 140 million people worldwide are exposed to inorganic arsenic through contaminated drinking water. Chronic exposure increases risk for cancers as well as cardiovascular, respiratory, and neurologic diseases. Arsenic metabolism involves the AS3MT (arsenic methyltransferase) gene, and arsenic metabolism efficiency (AME, measured as relative concentrations of arsenic metabolites in urine) varies among individuals. Inherited genetic variation in the 10q24.32 region, containing AS3MT, influences AME, but the mechanisms remain unclear. To better understand these mechanisms, we use tissue-specific expression data from GTEx (Genotype-tissue Expression project) to identify cis-eQTLs (expression quantitative trait loci) for AS3MT and other nearby genes. We combined these data with results from a genome-wide association study of AME using "colocalization analysis," to determine if 10q24.32 SNPs (single nucleotide polymorphisms) that affect AME also affect expression of AS3MT or nearby genes. These analyses identified cis-eQTLs for AS3MT in 38 tissue types. Colocalization results suggest that the casual variant represented by AME lead SNP rs4919690 impacts expression of AS3MT in 13 tissue types (> 80% probability). Our results suggest this causal SNP also regulates/coregulates expression of nearby genes: BORCS7 (43 tissues), NT5C2 (2 tissues), CYP17A1-AS1 (1 tissue), and RP11-724N1.1 (1 tissue). The rs4919690 allele associated with decreased AME is associated with decreased expression of AS3MT (and other coregulated genes). Our study provides a potential biological mechanism for the association between 10q24.32 variation and AME and suggests that the causal variant, represented by rs4919690, may impact AME (as measured in urine) through its effects on arsenic metabolism occurring in multiple tissue types. - Source: PubMed
Chernoff MeytalTong LinDemanelis KathrynVander Griend DonaldAhsan HabibPierce Brandon L