DCP1A
- Known as:
- DCP1A
- Catalog number:
- Y213512
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- DCP1A
Related genes to: DCP1A
- Gene:
- DCP1A NIH gene
- Name:
- decapping mRNA 1A
- Previous symbol:
- -
- Synonyms:
- HSA275986, SMIF, SMAD4IP1
- Chromosome:
- 3p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-07
- Date modifiied:
- 2015-07-16
Related products to: DCP1A
Related articles to: DCP1A
- Hyperosmotic shock and the resulting cell volume compression are commonly experienced by organs such as the kidneys, causing rapid formation of hyperosmotic phase separation (HOPS) condensates in the cytoplasm and nucleoplasm. Although the causal relationship between hyperosmotic shock and condensation has been characterized, the diffusion dynamics of biomolecular condensates in hyperosmotically compressed cells and their underlying mechanisms remain largely unknown. - Source: PubMed
Publication date: 2026/03/24
Halder BisalGao GuomingAhnoud ArminStakenas ShelbySumrall Emily RWalter Nils G - Keratoconus (KC) is a vision-threatening condition with a higher prevalence and earlier onset in males than in females. The study aims to investigate sex-associated transcriptomic features of KC and assess whether sex hormones modulate stromal remodelling. - Source: PubMed
Publication date: 2026/03/03
Sun YiningLi QixinWu XiaoqingYu XintongWang RuoqiSun BinjiaWang KaishengYu YeChen ShihaoJiang DanChen Wei - Hyperosmotic shock and the resulting cell volume compression are commonly experienced by organs such as the kidneys, causing rapid formation of hyperosmotic phase separation (HOPS) condensates in the cytoplasm and nucleoplasm. Although the tight relationship between hyperosmotic shock and condensation has been characterized, the dynamics of biomolecular condensates in hyperosmotically compressed cells and their regulatory mechanisms remain largely unknown. - Source: PubMed
Publication date: 2025/06/17
Halder BisalGao GuomingAhnoud ArminStakenas ShelbySumrall Emily RWalter Nils G - Seneca Valley virus (SVV), a new member of Picornaviridae, causes idiopathic vesicular symptoms in pregnant sows and acute death in neonatal piglets, considerably damaging the swine industry. The viral protease 3C (3C) cleaves host immune-related molecules to create a favorable environment for viral replication. In this study, we found that mRNA decapping enzyme 1A (DCP1A) is a novel antiviral effector against SVV infection that targets 3D viral RNA-dependent RNA polymerase for OPTN-mediated autophagic degradation. To counteract this effect, SVV 3C targets DCP1A for cleavage at glutamine 343 (Q343), resulting in the cleaved products DCP1A (1-343) and DCP1A (344-580), which lose the ability to restrict SVV replication. In contrast, the 3C cleavage-resistant DCP1A-Q343A mutant exhibited stronger antiviral effects than the wild-type DCP1A. Additionally, the degradation of the viral 3D protein targeted by DCP1A was abolished after its cleavage by SVV 3C. In conclusion, our study demonstrated that SVV 3C is a pivotal ISG antagonist that cleaves DCP1A. These results offer novel insight into how viruses evade host immunity. - Source: PubMed
Publication date: 2025/02/28
Yang JingjingLi ZijianMa RuiyiXie ShijieWang DanQuan RongWen XuexiaSong Jiangwei - Translation and the formation of membraneless organelles are linked mechanisms to promote cell stress surveillance. LncRNAs responsive to ethanol stress transcr_9136 of the SEY6210 strain and transcr_10027 of the BY4742 strain appear to act on tolerance to ethanol in these strains. Here, we investigate whether the ethanol responsiveness of transcr_9136 and transcr_10027 and their role in ethanol stress are associated with protein biogenesis and membraneless organelle assembly. SEY6210 transcr_9136∆ and BY4742 transcr_10027∆ and their wild-type counterparts were subjected to their maximum ethanol-tolerant stress. The expression of the transcr_9136, transcr_10027, , and genes was accessed by qPCR. The level of DCP1a, PABP, and eIF4E proteins was evaluated by Western blotting. Bioinformatics analyses allowed us to check whether transcr_9136 may regulate the expression of RRP1 and predict the interaction between transcr_10027 and Tel1p. The cell death rate of SEY6210 strains under control and ethanol stress conditions was assessed by flow cytometry. Finally, we evaluated the total protein yield of all strains analyzed. The results demonstrated that transcr_9136 of SEY6210 seems to control the expression of and and reduce the general translation. Furthermore, transcr_9136 seems to act on cell membrane integrity. Transcr_10027 of BY4742 appears to inhibit processing body formation and induce a general translation level. This is the first report on the effect of lncRNAs on yeast protein synthesis and new mechanisms of stress-responsive lncRNAs in yeast, with potential industrial applications such as ethanol production. - Source: PubMed
Publication date: 2025/01/28
Schnepper Amanda PivetaKubo Agatha M SPinto Camila MoreiraGomes Ramon Hernany MartinsFioretto Matheus NaiaJustulin Luís AntonioBraz Aline M MGolim Marjorie de AssisGrotto Rejane M TValente Guilherme Targino