DEAD_box protein 6
- Known as:
- DEAD box protein 6
- Catalog number:
- Y213499
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- DEAD box protein 6
Related genes to: DEAD_box protein 6
- Gene:
- ADAT2 NIH gene
- Name:
- adenosine deaminase tRNA specific 2
- Previous symbol:
- DEADC1
- Synonyms:
- dJ20N2.1, TAD2
- Chromosome:
- 6q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-26
- Date modifiied:
- 2019-01-18
Related products to: DEAD_box protein 6
Related articles to: DEAD_box protein 6
- Adenosine-to-Inosine (A-to-I) modification is one of the most common transfer RNA (tRNA) modifications in humans. However, the role of A-to-I tRNA modification in colorectal cancer (CRC) remains poorly understood. - Source: PubMed
Publication date: 2026/03/17
Cheng Cillian HJi FenfenShen JianmingJiao YingChen DanyuYang HuanYe LiufangTao RuizhiWei QinyaoKang WeiYu JunWong Chi Chun - RNA modification enzymes (RMEs) are key post-transcriptional regulators that impact RNA stability, translation, and splicing. Dysregulation of RMEs is closely associated with tumor initiation and progression. However, their global regulatory patterns and clinical relevance across cancer types remain incompletely characterized. - Source: PubMed
Publication date: 2026/01/28
Zhan QianqianSun HuihuiWang XiangtingLiang Xiaolin - Carcass traits are among the most critical production characteristics in broiler chickens. Therefore, the precise identification of genetic variants and candidate genes affecting these traits is highly valuable for enhancing breeding efficiency and overall productivity in poultry. In this study, a genome-wide association study (GWAS) was conducted to analyse seven carcass traits in 1 498 cocks from a Chinese indigenous yellow-feathered meat chicken population, which had been subjected to three generations of selective breeding for improved BW and feed conversion ratio. The assessing traits included breast muscle weight (BMW), BWs at 42 and 56 days (BW42, BW56), carcass weight (CW), eviscerated weight (EW), eviscerated weight with giblets (EWG), and leg weight (LW). Six significant single-nucleotide polymorphism (SNP) sites were identified by using the "Jingxin No. 1″ 55 K SNP microarray and bioinformatic analysis. These SNPs were annotated to six candidate genes on chromosomes 1, 2, 3, 4, 9, and Z, including SPHKAP, ALCAM, CMTM7, ADAT2, LIMCH1 and AP3B1, with the variant in the SPHKAP gene harboured a frameshift deletion in the coding region. Our study identified novel variants related to chicken carcass traits, which provide a new insight into the genetic mechanism of chicken carcass traits. These trait-associated genetic variants could facilitate the selection of more efficient broilers. - Source: PubMed
Publication date: 2025/12/23
Pan ZGeng HLi DCheng XLiu Y - Transfer RNAs (tRNAs) are subject to various chemical modifications that influence their stability or function. Adenosine to Inosine (A-to-I) editing in the tRNA anticodon at position A34 is an important modification that expands anticodon-codon recognition at the wobble position and is required for normal mRNA translation. The relevance of tRNA editing in cancer remains unexplored. Here we show that the genes encoding the ADAT2/3 deaminase complex, responsible for A-to-I tRNA editing in humans, are commonly amplified and/or overexpressed in several tumor types including liposarcoma (LPS). We find that LPS cell growth and tumorigenicity is dependent on ADAT2/3 tRNA editing activity. Mechanistically, we find decreased tRNA editing upon ADAT2 depletion, defective translation of a subset of mRNAs, and altered protein homeostasis. Thus, ADAT2 promotes oncogenesis and the translation of growth promoting mRNAs that are enriched in NNC codons that lack cognate tRNAs and therefore depend on A-I tRNA editing for decoding and mRNA translation. Our results identify ADAT2/3 as a potential new cancer therapeutic target. - Source: PubMed
Publication date: 2025/09/02
Ramirez-Moya JuliaAntika Titi RindiLiu QiXiong XushenAli RajaGutierrez AlejandroGregory Richard I - Ever since the legendary publication by Francis Crick in JMB introducing the wobble hypothesis in 1966, inosine has been a permanent part of molecular biology. This review aims to integrate the rich array of novel insights emerging from subsequent research on the adenine-to-inosine modification of tRNA, with an emphasis on the results obtained during the last 5 years. Both the grand panorama of 4 billion years of evolution of life and the medical implications of defects in inosine modification will be reviewed. The most salient insights are that: (1) inosine at position 34 (the first position in the anticodon) is not universally present in the tree of life; (2) in many bacteria just a single homodimeric enzyme (TadA) is responsible for both tRNA inosine modification and mRNA inosine modification; (3) rapid progress is currently being made both in the molecular understanding of the heterodimeric ADAT2/ADAT3 enzyme responsible for inosine modifications in eukaryotes and in experimental capabilities for monitoring both the cytoplasmic tRNA pool and their modifications; (4) for selected tRNAs, inosine modification at position 37 has been demonstrated but this modification remains under-studied; (5) modification of tRNAs known to contain inosine can be incomplete; (6) the GC content of the T-stem is of great importance for wobble behavior, including wobbling behavior of inosine; and (7) the tRNA inosine modification is of direct relevance to human disease. In summary, research on inosine continues to yield important novel insights. - Source: PubMed
Publication date: 2025/05/17
van der Gulik Peter T SHoff Wouter D