DCDC2
- Known as:
- DCDC2
- Catalog number:
- Y213497
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- DCDC2
Related genes to: DCDC2
- Gene:
- DCDC2 NIH gene
- Name:
- doublecortin domain containing 2
- Previous symbol:
- DFNB66
- Synonyms:
- RU2, KIAA1154, DCDC2A, NPHP19
- Chromosome:
- 6p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-20
- Date modifiied:
- 2016-10-13
Related products to: DCDC2
Related articles to: DCDC2
- - Source: PubMed
Publication date: 2026/03/26
Gestels ThomasMarino AngelaDumitriu DanaStephenne Xavier - The gene encodes a ciliary protein involved in microtubule polymerization and ciliary assembly. Although has been associated primarily with neuronal migration and ciliopathies affecting the liver and kidneys, its role in pulmonary disease has not been clearly defined. Ciliary dysfunction, particularly in motile cilia of the respiratory tract, can impair mucociliary clearance and lead to bronchiectasis, as seen in primary ciliary dyskinesia. Here, we report a rare case of bronchiectasis associated with a pathogenic (NM_016356.5):c.558del p.(Arg186SerfsTer5) variant, in which other known causes of bronchiectasis were excluded. This finding expands the phenotypic spectrum of -related disease, and suggests a potential link between mutations and respiratory involvement. Early recognition of this association might support timely pulmonary screening and intervention to improve long-term outcomes. - Source: PubMed
Publication date: 2026/02/09
AlSaedi Khulud SMazi Ahlam A - Developmental language disorders (DLDs) are common neurodevelopmental conditions, affecting approximately 7-10% of children, with significant impacts on communication, academic achievement, and social integration. While genetic factors are known contributors, the underlying genomic architecture and biological pathways remain incompletely understood. This analysis explores key genomic biomarkers of DLD and investigates their functional interactions. - Source: PubMed
Adnan Hassan RafalAl-Fatlawi Ali - Developmental Dyslexia (DD) and Attention-deficit/hyperactivity disorder (ADHD) are neurodevelopmental disorders that often coexist and share complex genetic underpinnings. Our case study integrates psychological assessments and whole exome sequencing to explore the genetic basis of DD and ADHD co-occurrence in a single proband (a nine-year-old female born to healthy) from a consanguineous Pakistani family. We present a proband with symptoms of impulsivity, inattention, and severe hyperactive behavior, along with speech impairment and moderate learning disabilities. The study identified non-synonymous variations in genes associated with both disorders, such as , , and , , , , , and . Network analysis revealed key pathways like , , and shedding light on potential mechanisms underlying the observed phenotypes. The study emphasizes the complexity of these conditions and underscores the need for personalized interventions to address diagnosis challenges. - Source: PubMed
Publication date: 2024/09/22
Haider ShujjahMondal TanmoyNawaz IrumAzam MaleehaGhosh Somiranjan - ICC is a malignant tumor that originates from the intrahepatic bile ducts with insidious symptoms and a poor prognosis. Early diagnosis methods and therapeutic targets are urgently needed for ICC. - Source: PubMed
Publication date: 2025/06/18
Wan WenzeLi YuanSun WentaoCheng ZeweiMa FenShen ShengLiu HoubaoZhang Jiwei