ADAM33
- Known as:
- ADAM33
- Catalog number:
- Y213451
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADAM33
Related genes to: ADAM33
- Gene:
- ADAM33 NIH gene
- Name:
- ADAM metallopeptidase domain 33
- Previous symbol:
- C20orf153
- Synonyms:
- DKFZp434K0521, dJ964F7.1
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-10
- Date modifiied:
- 2015-08-26
Related products to: ADAM33
Related articles to: ADAM33
- To explore the potential association between five single nucleotide polymorphisms (SNPs) (rs44707, rs612709, rs598418, rs2280089, and rs574174) in the ADAM33 gene and asthma susceptibility in the Zhuang population of Guangxi, China. - Source: PubMed
Publication date: 2026/03/21
Qin Zan-MeiHuang Xue-MeiWei XuanHe Zhi-YiDeng Jing-Min - The phenotypic nature of multimorbidity in severe asthma is poorly understood. Our aims in this study were to define multimorbidity phenotypes and their characteristics in severe asthma across Europe by identifying and characterising co-aggregation of comorbidities. - Source: PubMed
Publication date: 2026/02/05
Freeman AnnaRink SašaBansal Aruna TFrankemölle BettySingh MeharSont Jacob KBossios ApostolosAinsworth BenHyland MichaelChaudhuri RekhaMatisa DaceMihaltan FlorinSpanevello AntonioHeffler EnricoAdcock IanZappa MartinaCanonica Giorgio WalterBrusselle GuyBourdin ArnaudMaria Luigia Costanzo Giulia AnnaHorvath IldikoLúðvíksdóttir DóraPrincipe StefaniaKopač PeterLoureiro Cláudia ChavesSiddiqui SalmanEgesten ArneKalinauskaite-Zukauske VirginijaDimic-Janjic SanjaRoberts GrahamHromis SanjaMilenkovic BranislavaVarkonyi-Sepp JuditGoksel OzlemPereira Ana MDjukanovic RatkoRizzi AngelaCaminati MarcoHou RuihuaŠtajduhar AnamarijaParóczai DóraBrussino LuisaHeaney LiamHaitchi Hans MichaelBonini MatteoBieksiene KristinaDamadoglu EbruYasinska ValentynaGemicioglu BilunGrle Sanja PopovićBrinke Anneke TenCsoma ZsuzsannaKroica IvetaKuna PiotrDahlen BarbroPorsbjerg CelesteHodge HilaryŠkrgat SabinaSchleich FlorenceKurukulaaratchy Ramesh J - The Body Mass Index (BMI), integrating body weight and length, is a widely used metric for obesity assessment in humans. As pigs serve as crucial biomedical models, the application of BMI in swine and its genetic basis remain poorly explored. This study aimed to investigate the genetic architecture of pig BMI and compare two carcass-based BMI metrics (BMI-S and BMI-O) for breeding applicability. A total of 439 Landrace × Yorkshire crossbred pigs were genotyped with a 50 K SNP chip; heritability was estimated via a mixed linear model, and genome-wide association study (GWAS) was performed using the BLINK model. BMI-S and BMI-O exhibited moderate-to-high heritability of 0.55 and 0.47, respectively, with 17 genome-wide significant SNPs detected-including the top associated SNP on chromosome 4 and on chromosome 7. Key candidate genes (, , , ) and 5 SNP-trait associations validated in PigQTLdb were linked to lipid/energy metabolism and muscle development. Carcass-based BMI improved phenotypic accuracy, and our findings provide core genetic markers and a theoretical basis for molecular breeding of pig body conformation and lipid deposition traits. - Source: PubMed
Publication date: 2026/01/14
Jin LongBai ChunyanChen JinghanFeng ChengyueDong FengyiZhang XiaoranFei JunwenHe YuLiu WuyangChen ChangyiSun BoxingWang DaliSun Hao - Gastroesophageal reflux disease is a common condition that can lead to various complications, with gastroesophageal reflux cough (GERC) being one of the notable manifestations. Despite conventional therapies targeting acid suppression, recurrence and incomplete efficacy remain significant challenges. Tongjiang Hewei Decoction (THD), a traditional Chinese formulation, has shown clinical promise in alleviating GERD-related symptoms. However, its therapeutic mechanisms in GERC remain unexplored. In this study, the airway hyperresponsiveness (AHR) guinea pig model was constructed by infusing hydrochloric acid into the lower esophagus. Transcriptome sequencing was used to identify THD-related possible pathways in GERC. Lung resistance was measured to evaluate lung function. Hematoxylin-eosin staining, immunohistochemistry, real-time fluorescence quantitative polymerase chain reaction, and western blotting were employed to assess airway remodeling. Airway smooth muscle cells were isolated to further investigate the effects of THD in vitro. In vivo assay indicated that THD reduced lung resistance and attenuated bronchial wall thickening, mucus hypersecretion, and inflammatory infiltration in a dose-dependent manner. Mechanistically, THD suppressed ADAM33, RhoA/ROCK, and Epac1/Rap1 pathways in vivo, correlating with reduced α-SMA and sm-MHC expression. Transcriptomic analysis revealed that THD exerted its effects through the Epac1/Rap1 signaling pathway. The Rap1 activator reversed THD's anti-AHR effects. In vitro, THD inhibited contractile protein synthesis via ADAM33 silencing, while ADAM33 overexpression abolished this effect. Collectively, THD alleviated GERC-induced AHR through dual modulation of the ADAM33/RhoA/ROCK axis and Epac1/Rap1 signaling, providing novel mechanistic insights into its therapeutic potential. These findings position THD as a multifaceted candidate for GERC management, bridging traditional medicine with modern molecular pharmacology. - Source: PubMed
Publication date: 2025/12/18
Zhang XiulianLi XueliangCheng YanmeiWei LeiLiu FangyingLi LiZhang WeiYan Xiuli - Cystic fibrosis (CF) is a rare genetic disease caused by pathogenic variants in the () gene, with wide clinical variability influence not only by the genotype but also by environmental and modifier genes such as (). The rs2280091 variant in may affect lung function and contribute to differences in disease severity. This study investigated the association between this genetic variant and lung function in CF patients. This cross-sectional study included 55 CF patients from a Brazilian center, with diagnosis confirmed by sweat testing and genotyping. Pulmonary function was evaluated by spirometry before and after bronchodilator (BD) administration according to the American Thoracic Society/European Respiratory Society guidelines, analyzing Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), FEV1/FVC ratio, Forced Expiratory Flow at 25%, 50%, and 75% of FVC (FEF25%, FEF50%, and FEF75%), mean Forced Expiratory Flow between 25% and 75% of FVC (FEF25-75%), and Maximal Expiratory Forced Flow (MEF). The rs2280091 variant was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and statistical analyses included Kruskal-Wallis and Mann-Whitney tests, chi-square (χ) tests, and calculation of odds ratios (ORs) with 95% confidence intervals (95% CI). The study included 55 CF patients, predominantly female (96.4%) and Caucasian (52.7%), with a median age of 17 years. genotyping revealed F508del/F508del as the most common genotype (52.7%). Analysis of the rs2280091 variant demonstrated that the AA genotype was most frequent in both CF patients (69.1%) and healthy controls (78.6%). Notably, the GG genotype was significantly enriched in CF patients (18.2%) compared with the controls (0.02%), yielding an odds ratio of 12.06 (95% CI: 4.86-29.91), while the G allele was also associated with increased disease risk (24.5% vs. 11.6%). Pulmonary function assessment indicated that carriers of the GG genotype or G allele had higher Forced Expiratory Flow parameters (FEF25%, FEF50%, FEF25-75%, and MEF) and improved BD responsiveness, suggesting a potential modulatory role of in peripheral airway function in CF. The G allele of the rs2280091 variant was more frequent among recruited CF patients and associated with improved peripheral airway function and BD response. These findings may reflect a survivor effect, in which carriers of this allele are more likely to reach clinical follow-up and recruitment rather than indicating a direct association with increased disease risk. - Source: PubMed
Publication date: 2025/11/29
Dos Santos Vinícius SantiagoMello Lucas SilvaMarques Luiz Felipe AzevedoSilva Luana RodriguesBertuzzo Carmen SílviaRibeiro José DirceuMarson Fernando Augusto Lima