SMUG1
- Known as:
- SMUG1
- Catalog number:
- Y213340
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- SMUG1
Related genes to: SMUG1
- Gene:
- SMUG1 NIH gene
- Name:
- single-strand-selective monofunctional uracil-DNA glycosylase 1
- Previous symbol:
- -
- Synonyms:
- UNG3, FDG, HMUDG
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2006-01-06
- Date modifiied:
- 2014-11-19
Related products to: SMUG1
Related articles to: SMUG1
- Maternal obesity (pregravid body mass index >30 kg/m), which has reached epidemic levels in the US, increases the incidence of cardiovascular disease and all cause premature death in the offspring. The placenta modulates fetal access to lipids and other nutrients and is considered a key player in fetal growth and maturation. However, the complex interplay between dysregulated metabolism in mothers with obesity and placental pathways mediating impacts on fetal development that predispose offspring to morbidities later in life, is poorly understood. - Source: PubMed
Publication date: 2026/01/28
Spadafora RuggeroZhang JiayiNirmala N RLi XueO'Tierney-Ginn Perrie - Small base lesions in DNA are primarily repaired through the base excision repair pathway, which is initiated by DNA glycosylases. This review focuses on single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), an enzyme whose name incompletely captures its broader biological roles. SMUG1 excises a wide range of substrates beyond uracil, shows a preference for double-stranded DNA, and has been reported to be a bifunctional DNA glycosylase with a weak lyase activity. Moreover, SMUG1 plays roles extending beyond DNA repair, including functions in RNA quality control and RNA biogenesis. Recently, genetic interactions have been described between SMUG1 and proteins that safeguard stressed replication forks, implicating a function for SMUG1 in cancer cell biology. Understanding SMUG1's full repertoire is key to uncovering its role in genome maintenance and unlocking its potential as a therapeutic target. Here, we review the biochemical properties reported for SMUG1 and its distinct functions from other uracil-DNA glycosylases . We also highlight the emerging role of SMUG1 in cancer cells and its potential as a therapeutic target, emphasizing the need to define the genetic and molecular contexts in which its modulation may be beneficial. - Source: PubMed
Publication date: 2025/12/12
Rudolfova NatalieSkjetne Alexander MyhrMontaldo Nicola PVisnes TorkildNilsen Hilde LogeMichel Maurice - The incorporation of nucleoside analogs into DNA by polymerases, followed by their removal through base excision repair (BER), represents a promising strategy for cancer chemotherapy. In this study, we investigated the incorporation and cytotoxic effects of several nucleoside analogs-some of which are epigenetic reprogramming intermediates-in the U87 glioblastoma cell line. We found that two analogs, 5-hydroxymethyl-2'-deoxyuridine (5HmdU) and trifluorothymidine (TFT), are both cytotoxic and are efficiently incorporated into genomic DNA. In contrast, the 5-carboxy analogs-5-carboxy-2'-deoxyuridine (5CadU) and 5-carboxycytidine (5CadC)-showed no cytotoxicity and were not incorporated into DNA. Interestingly, 5-hydroxymethyl-2'-deoxycytidine (5HmdC) was cytotoxic but was not directly incorporated into DNA. Instead, it was deaminated into 5HmdU, which was then incorporated and likely responsible for the observed toxicity. 5HmdU is actively removed from DNA through the BER pathways. In contrast, TFT remains stably incorporated and is neither excised by BER nor does it hydrolyze into 5CadU-a known substrate for the DNA glycosylase SMUG1. We also found that N-benzyladenosine (BzAdo), an inhibitor of the enzyme 2'-deoxynucleoside 5'-phosphate N-hydrolase (DNPH1), enhances the cytotoxicity of 5HmdU. However, the thymidine phosphorylase inhibitor tipiracil hydrochloride (TPI) does not increase the cytotoxic effect of TFT in U87 cells. Together, these findings highlight 5HmdU and TFT as promising chemotherapeutic agents for glioblastoma, each with distinct mechanisms of action and cellular processing. - Source: PubMed
Publication date: 2025/08/01
Herring Jason LSowers Mark LConrad James WHackfeld Linda CChang-Gu BruceDilawari RahulSowers Lawrence C - Pancreatic cancer is a lethal malignancy prone to gemcitabine resistance. The single-strand selective monofunctional uracil DNA glycosylase (SMUG1), which is responsible for initiating base excision repair, has been reported to predict the outcomes of different cancer types. However, the function of SMUG1 in pancreatic cancer is still unclear. - Source: PubMed
Publication date: 2025/08/11
Wu ZijianWang WeiHua JieZhang JingyaoLiu JiangShi SiZhang BoWang XiaohuiYu XianjunXu Jin - Recurrent pregnancy loss (RPL), which occurs in 1-5% of couples and nearly half of the cases remain unexplained, is a complex condition influenced by multiple factors. Previous investigations have demonstrated the role of m5C-related genes (MRGs) in cancer prognosis and the significance of epigenetic modifications during pregnancy. However, the connection between MRGs and the pathogenesis of RPL remains elusive. This study endeavors to elucidate this relationship through bioinformatics approaches. - Source: PubMed
Publication date: 2025/08/02
Luo HuanminLi ShuqingCao YumingXu JinfengWang Li