NOXO1
- Known as:
- NOXO1
- Catalog number:
- Y213332
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- NOXO1
Related genes to: NOXO1
- Gene:
- NOXO1 NIH gene
- Name:
- NADPH oxidase organizer 1
- Previous symbol:
- -
- Synonyms:
- P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-12-09
- Date modifiied:
- 2014-11-19
Related products to: NOXO1
Related articles to: NOXO1
- Colorectal cancer (CRC) is increasingly diagnosed in individuals under 50 years of age, yet the underlying genetic predisposition remains largely unexplained, particularly in mismatch repair (MMR)-proficient cases. This study aimed to identify novel hereditary CRC susceptibility genes by integrating germline and tumour whole-exome sequencing (WES) with transcriptomic profiling across a cohort of early-onset CRC (EOCRC) patients. Tumours were categorised using Consensus Molecular Subtypes (CMS) classification and analysed for mutational signature and burden. We used a novel 'All vs One' multi-omic integration approach to identify loss-of-function rare germline variants with concordant gene expression alterations in tumour tissue. Five candidate genes (ADCY4, NOXO1, CDHR2, ARHGAP10, EEF2K) were prioritised based on this approach and potential biological relevance in CRC. These findings highlight the molecular heterogeneity of EOCRC and demonstrate the utility of multi-omic approaches in refining germline variant interpretation. Integrating tumour transcriptomics enhances gene discovery efforts and supports a more comprehensive understanding of CRC heritability in younger individuals. - Source: PubMed
Publication date: 2026/01/15
López-Novo AnaelAmigo JorgeDacal AndrésRemedios-Espino DavidCubiella JoaquínÁlvarez-Sánchez María VictoriaLadra-González María JesúsFernández-López FernandoÁlvarez-Castro AnaCarlés SilviaCameselle-Teijeiro José ManuelCuatrecasas MiriamBalaguer FrancescCastellví-Bel SergiFernández-Rozadilla CeresCarracedo ÁngelRuiz-Ponte Clara - NADPH oxidase organizer 1 (NoxO1) is known as a scaffold cytoplasmic subunit of the reactive oxygen species (ROS) forming Nox1 complex. We previously identified an interaction between NoxO1 and Erbin, a cytosolic scaffold protein that associates with Epidermal Growth Factor Receptor (EGFR), but its ROS-independent roles remain poorly understood. Here, we demonstrate that NoxO1 overexpression remodels the endolysosomal system by expanding early endosomes and lysosomes. A calibrated six-compartment ordinary differential equation model of EGFR trafficking predicts a slowed down intracellular trafficking: NoxO1 overexpression increased internalization rates by 14 % while reducing degradative sorting by 48 %, lysosomal transfer by 24 %, and final degradation by 41 %. Using fluorescent cargo (EGF and BSA), we confirmed enhanced internalization and cargo accumulation in lysosomes, supporting the idea of prolonged lysosomal retention in NoxO1 overexpressing cells. Mechanistically, NoxO1 activated transcription factor EB (TFEB), the master regulator of lysosomal biogenesis, in an Erbin-dependent but ROS independent manner. Proximity ligation assays revealed spatial association of NoxO1, Erbin, EGFR, and TFEB, suggesting a multi-protein regulatory complex. Genetic ablation of Erbin abolished NoxO1-induced increases in early endosome (EEA1) and lysosome (LAMP1) markers, confirming Erbin's essential role. In conclusion, via its interaction with Erbin NoxO1 promotes activation of TFEB, contributes to lysosome formation while delaying cargo degradation. - Source: PubMed
Publication date: 2025/12/12
Hebchen MaureenHerwig FalkSchader TimSpaeth ManuelaMüller NiklasSchröder Katrin - Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex inflammatory disease whose environmental pathogenic factors remain unclear. Microplastics, as emerging environmental pollutants, have been confirmed to deposit in the respiratory tract and induce inflammatory responses; however, their molecular association with CRSwNP pathogenesis remains elusive. This study integrates transcriptomic data from microplastic-exposed human airway epithelial cells and single-cell transcriptomic data from CRSwNP patients, employing machine learning algorithms to screen core genes and systematically exploring disease mechanisms through single-cell analysis, pseudotime trajectory inference, cell-cell communication analysis, and transcriptional regulatory network analysis. The study identified 29 genes commonly upregulated in both microplastic exposure and CRSwNP, with NOXO1 being consistently identified as the core driver gene by all algorithms. Single-cell analysis revealed that myoepithelial cells exhibited specific high responsiveness to microplastic-related genes and showed significantly increased proportions in CRSwNP. Pseudotime analysis unveiled aberrant differentiation trajectories involving myoepithelial cells and basal cells, characterized by high expression of CCL20, CNN1, and MXRA5. Cell-cell communication analysis identified pathological crosstalk between myoepithelial cells and mast cells through the LAMB3-CD44 axis, while SCENIC analysis demonstrated significant activation of EMT-related transcription factors (TWIST1/2, SOX18) in myoepithelial cells. This study establishes for the first time a molecular mechanistic model of microplastic-induced CRSwNP: microplastics trigger oxidative stress by upregulating NOXO1, driving pathological reprogramming of myoepithelial cells, establishing inflammatory amplification loops with mast cells through the LAMB3-CD44 axis, and ultimately promoting polyp formation. These findings provide novel insights into the role of environmental factors in CRSwNP pathogenesis and identify potential therapeutic targets. - Source: PubMed
Publication date: 2025/12/13
Gao YunLi LejunHuang YixingZhao XudongTeng Yaoshu - Tick infestation is one of the main challenges in tropical beef cattle production, leading to significant economic losses. Knowledge of the molecular factors underlying natural tick resistance in cattle contributes to genetic selection through the identification of biomarkers that can be used to accurately identify animals resistant to ticks. Although several genes associated with resistance to ticks have been identified, the molecular mechanisms underlying tick resistance are yet to be elucidated. This study investigated the biological processes, pathways, and key proteins involved in the resistance to the tick Rhipicephalus (Boophilus) microplus in a tropically adapted beef cattle breed. Tick resistance was evaluated in 162 Caracu cows. Blood samples were collected from a subset of 16 extreme animals, including eight with a high tick load (SUS) and eight with a low tick load (RES), for proteomic analysis by LC-MS/MS. - Source: PubMed
Publication date: 2025/11/12
Abduch Natalya GReolon Henrique GSilva Rafael M OBaldi FernandoFragomeni Breno OLourenco DanielaPaz Claudia C PStafuzza Nedenia B - Gastric cancer (GC), a malignant and highly proliferative disease, has profoundly impacts a substantial global population and is associated with several variables, including genetic, epigenetic, and environmental impacts. Global variance is associated with infection and dietary factors. - Source: PubMed
Publication date: 2025/10/16
Qian ZixingBai WeiLi JiaxuanRao XianjunHuang GuodongZhang XuepingWu WenyuLiu JiabaoWei Wei