MDG1 _ DNAJB9
- Known as:
- MDG1 _ DNAJB9
- Catalog number:
- Y213329
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- MDG1 _ DNAJB9
Related genes to: MDG1 _ DNAJB9
- Gene:
- DNAJB9 NIH gene
- Name:
- DnaJ heat shock protein family (Hsp40) member B9
- Previous symbol:
- MDG1
- Synonyms:
- -
- Chromosome:
- 7q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-08-18
- Date modifiied:
- 2016-10-05
Related products to: MDG1 _ DNAJB9
Anti- MDG1 DNAJB9 Antibodyanti-MDG1 (3G4)anti-MDG1 (3G4)anti-MDG1 (3G4) type: Primary antibodies host: MouseAntibodies: DNAJB9 (aa61-75) HOST: Goat Clonality: pAbAntibodies: MDG1 _ DNAJB9 HOST: Goat Clonality: pAbDnaJ homolog subfamily B member 9,DNAJB9,Homo sapiens,Human,MDG1,Mdg-1,Microvascular endothelial differentiation gene 1 protein,UNQ743_PRO1471DnaJ homolog subfamily B member 9,Dnajb9,Mdg1,Mdg-1,Microvascular endothelial differentiation gene 1 protein,Rat,Rattus norvegicusDnaJ homolog subfamily B member 9,Dnajb9,mDj7,Mouse,Mus musculusDNAJB7 Gene DnaJ (Hsp40) homolog, subfamily B, member 7DNAJB9DNAJB9DNAJB9DNAJB9DNAJB9 Related articles to: MDG1 _ DNAJB9
- Amyloidosis comprises a heterogeneous group of diseases characterized by extracellular deposition of β-pleated-sheet fibrillar proteins that cause progressive organ dysfunction. Among immunoglobulin-related amyloidosis, combined heavy- and light-chain (AHL) amyloidosis is extremely rare, which accounts for approximately 7%. Several studies have demonstrated that complement components can be detected in renal amyloidosis. We report a rare case of renal AHL amyloidosis with marked complement deposition with clinicopathologic and proteomic insights. - Source: PubMed
Publication date: 2026/04/30
Yamamoto YoshihiroShinzato TakahiroShishihara ShusukeMatsuo KenIshikawa ArimiKuwahara NaomiShimizu AkiraNagai Kojiro - Fibrillary glomerulonephritis (FGN) is a rare glomerular disease characterized by proteinuria, hematuria, renal insufficiency, and hypertension and was first described in 1977. Rare cases of lupus nephritis (LN) have been reported to show fibril formation similar to that observed in FGN. To date, only 6 cases of FGN associated with systemic lupus erythematosus have been reported. - Source: PubMed
Publication date: 2026/04/23
Lin Jian-YuLin Su-XianDong Shao-ShaoWang Mu-Dan - Normal pregnancy involves the modulation of thousands of maternal plasma proteins, and protein values not within the normal range may indicate the development of adverse pregnancy outcomes. A decrease in placental growth factor and an increase in soluble fms-like tyrosine kinase 1 in maternal plasma were shown to be associated with fetal death at the time of diagnosis and to predict this devastating pregnancy outcome at 24 to 28 weeks of gestation. However, these proteomic dysregulations are also present in other obstetrical syndromes, and more specific and sensitive biomarkers are needed to implement preventive strategies. - Source: PubMed
Publication date: 2026/04/02
Romero RobertoBhatti GauravChaiworapongsa TinnakornGomez-Lopez NardhyMeyyazhagan ArunChaemsaithong PiyaJung EunjungAwonuga Awoniyi OKim Yeon MeeGudicha Dereje WKim Chong JaiBryant David RHassan Sonia STarca Adi L - Fibrillary glomerulonephritis is a rare cause of proteinuric kidney disease characterized by Congo red-negative fibrillary deposits and typically shows DNAJB9 positivity on immunohistochemistry. Amyloidosis is defined by Congo red positivity and can be typed by laser microdissection-tandem mass spectrometry when routine studies are inconclusive. We report the case of a 64-year-old man with proteinuria and declining kidney function whose kidney biopsy showed DNAJB9-positive fibrillary glomerulonephritis in glomeruli, but Congo red-positive deposits confined to the medulla were DNAJB9 negative. Laser microdissection-tandem mass spectrometry of the medullary deposits identified apolipoprotein A-IV amyloidosis, establishing concurrent fibrillary glomerulonephritis and apolipoprotein A-IV amyloidosis in the same biopsy. Apolipoprotein A-IV amyloidosis is often medullary predominant and, in rare hereditary forms related to autosomal dominant variants, may have implications for family members. Although apolipoprotein A-IV amyloidosis has been reported in cardiac amyloidosis, transthoracic echocardiography and cardiac magnetic resonance imaging showed no evidence of cardiac amyloid involvement in this patient. This case highlights that discordant staining patterns with DNAJB9-positive fibrillary glomerulonephritis alongside Congo red positivity in DNAJB9-negative areas should prompt consideration of dual pathology and targeted mass spectrometry to accurately type deposits and guide management. - Source: PubMed
Publication date: 2026/02/09
Ahmed SumaiyaCanney MarkStarkell GinetteMassicotte-Azarniouch David - Glioblastoma (GBM) is an aggressive tumor with limited therapeutic options. Zika virus (ZIKV) has demonstrated activity against GBM; however, the cellular pathways behind this interaction remain unclear. We systematically reviewed open-access primary studies assessing differentially expressed genes (DEGs) in GBM models infected with wild-type or engineered ZIKV using transcriptomic approaches (inclusion criteria); reviews, restricted-access studies, commentaries, preprints, abstracts, and articles lacking data or not meeting these conditions were excluded (PROSPERO CRD420251077092). We performed a pathway analysis of reported DEGs. PubMed and Google Scholar were searched up to 5 March 2025; 139 records were identified and 5 met the eligibility criteria. Risk of bias was evaluated using an adapted ToxRTool for in vitro experiments and the SYRCLE RoB tool for in vivo models. Altogether, 4360 genes were reported as upregulated and 2072 as downregulated; 12 genes (, , , , , , , , , , , and ) were consistently upregulated, none were consistently downregulated. Pathway analysis of the studies providing complete DEG lists identified 23 commonly enriched pathways mostly related to interferon signaling. These findings may help guide future research in this field; nevertheless, methodological heterogeneity limits comparability, reinforcing the need for standardized protocols. Funding: ITpS, CNPq, and FAPEMIG. - Source: PubMed
Publication date: 2026/02/15
Menezes DiegoReis Clarisse RezendeMamede IzabelaGeddes Victor Emmanuel Vianade Souza Renan PedraAguiar Renato Santana