ARAP2
- Known as:
- ARAP2
- Catalog number:
- Y213277
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ARAP2
Related genes to: ARAP2
- Gene:
- ARAP2 NIH gene
- Name:
- ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
- Previous symbol:
- CENTD1
- Synonyms:
- PARX
- Chromosome:
- 4p14
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-29
- Date modifiied:
- 2016-10-05
Related products to: ARAP2
Related articles to: ARAP2
- To investigate the differences in meat quality between high (FH) and low (FL) subcutaneous fat thickness in Baicheng oil chickens and their possible regulatory mechanisms, this study jointly analysed the transcriptome and metabolome characteristics of the liver and subcutaneous fat tissue of Baicheng oil chickens. The results showed that there were significant differences in muscle fatty acid content between the FH and FL groups. Through a combined analysis of the transcriptome and metabolome of the liver and subcutaneous fat tissue of Baicheng oil chickens, differentially expressed genes (DEGs) and metabolites such as ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 (ARAP2)-N-Acetylhistidine, phosphoenolpyruvate carboxykinase 1 (PCK1)-ACar 16:1, and PCK1-ACar 20:2 were identified as having significant correlations, synergistically regulating the lipid metabolism process in chickens. This study contributes to an in-depth understanding of the mechanisms of fat regulation and the formation of excellent meat quality traits in local chickens and provides a basis for the identification of biomarkers of breeding value. - Source: PubMed
Publication date: 2026/04/02
Zhao XiaoyuYao YangLi HaiyingLiao HerongDong WeiWu Yingping - Interferon-gamma (IFNγ) is critical for immunity against intra-macrophagic pathogens, signaling through the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway to induce a tyrosine-phosphorylation cascade that ensures a potent immune response. Excessive JAK-STAT signaling can drive hyperinflammation and autoimmunity; thus, signaling is tightly and selectively regulated by the IFNγ-inducible protein, suppressor of cytokine signaling 1 (SOCS1). SOCS1 inhibits signaling by directly blocking JAK kinase activity. Here, we identified a SOCS1-interacting partner, ankyrin repeat and pleckstrin homology domain 2 (ARAP2), that fine-tunes SOCS1 function. We report that tyrosine 415 in ARAP2 binds the SOCS1-Src homology 2 (SH2) domain and limits the ability of SOCS1 to inhibit IFNγ signaling. Our findings show that ARAP2 promotes the IFNγ response through a phosphorylation-dependent interaction with the negative regulator SOCS1, and this exacerbates inflammation in a mouse model of influenza virus infection. - Source: PubMed
Publication date: 2025/12/15
Keating NarelleDoggett KarenBidgood Grace MMeza Guzman Lizeth GDagley Laura FLi KunlunWilliams Bailey EGabrielyan AnnaAlvarado CarolinaBroomfield Benjamin JDuckworth Brigette CHockings ColinYousef JumanaLeong EvelynMorris RhiannonKueh AndrewGarnham Alexandra LGiner GöknurCasanova Jean-LaurentBoisson-Dupuis StephanieBabon Jeffrey JLinossi Edmond MTate Michelle DGroom Joanna RNicholson Sandra E - Fish transportation, a routine operation in aquaculture, can induce immune responses in fish, potentially affecting their health. Nevertheless, the immune response mechanisms involved in microRNAs (miRNAs) under transport stress remain unclear. Therefore, we investigated the immune response strategy of miRNAs in intestines of hybrid yellow catfish under transport stress via physiological, biochemical and RNA-seq analysis. We found that transportation induced innate immune response of intestines characterized by significant increases in alkaline phosphatase, acid phosphatase, lysozyme, and complement 3 level. Meanwhile, 50 differentially expressed miRNAs were identified and comprehensive analysis of miRNA-mRNA sequencing showed their targets genes involved in 9 immune-related pathways. Notably, the miRNAs involved in immune regulation, such as miR-29a/b, miR-106, miR-454-3p and miR-455, were notably upregulated following the induction of transport stress, while miR-196a-5p was significantly downregulated. In addition, their corresponding target genes such as tkt, mafg, arap2, nfatc2, egr2 and wnk4 showed opposite expression trends, suggesting that these genes may be the key immunomodulatory targets of corresponding miRNA. Here, we focused on the regulatory function of miR-455 and its predictive target genes egr2. Double luciferase assay revealed that miR-455 might exist binding site in the 3'-UTR sequence of egr2 mRNA. Interestingly, silencing miR-455 under transport stress led to the increase of intestinal egr2 expression, affected intestinal immune and inflammation responses, and caused intestinal tissue damage and abnormal secretion of mucous substances. In conclusion, transport stress triggered intestinal immune response, and multiple miRNAs played important role in immune response, among which miR-455 might be an important biomarker. These findings not only improve the understanding of the immunomodulatory function of miRNA in fish, but also provide a theoretical basis for screening potential regulatory targets under transport stress. - Source: PubMed
Publication date: 2025/07/01
Zheng TaoTao YifanLu SiqiQiang JunXu Pao - Sperm infertility or subfertility is detrimental to the precious highland germplasm like yak whose population has been gradually declining in India. Understanding the 'omic' landscape of infertile or subfertile yak sperm can reveal some interesting insights. In an attempt to do the same, this study considered the semen of infertile or subfertile yak bulls for whole-genome and transcriptome evaluations. DNA sequencing revealed that the yak sperm genome contains the necessary genes to carry out all the important biological processes related to the growth, development, survival and multiplication of an organism. Interestingly, RNA Seq results highlighted that genes like , , and showed increased expression, while biological processes related to immune response (GO:0043308, GO:0002447, GO:0002278, GO:0043307, GO:0043312, GO:0002283, GO:0043299 and GO:0002446) were significantly overrepresented. These findings hint at a possible role played by immune system in regulating infertility or subfertility in yaks. Further, in-depth studies can validate these findings and help in improving our biological understanding in this area. - Source: PubMed
Publication date: 2024/10/17
Das Pranab JyotiKour AneetBhati JyotikaMishra Dwijesh ChandraSarkar Mihir - Metastatic prostate cancer (mPCa) is a widespread disease with high mortality. Unraveling molecular mechanisms of disease progression is of utmost importance. The microenvironment in visceral organs and the skeletal system is of particular interest as a harbinger of metastatic spread. Therefore, we performed a comprehensive transcriptomic analysis of prostate cancer lung metastases with a special focus on differentially expressed genes attributable to the microenvironment. Digital gene expression analysis using the NanoString nCounter analysis system was performed on formalin-fixed, paraffin-embedded (FFPE) tissue from prostate cancer (PCa) lung metastases (n = 24). Data were compared to gene expression data from primary PCa and PCa bone metastases. Bioinformatic analysis was performed using several publicly available tools. In comparison to prostate cancer bone metastases, 209 genes were significantly upregulated, and 100 genes were significantly downregulated in prostate cancer lung metastases. Among the up-regulated genes, the top 10 genes with the most significant P-value were HLA-DPB1, PTPRC, ITGB7, C3, CCL21, CCL5, ITGAM, SERPINA1, MFAP4, ARAP2 and among the down-regulated genes, the top 10 genes with the most significant P-value were FOXC2, TWIST1, CDK14, CHAD, IBSP, EPN3, VIT, HAPLN1, SLC44A4, TBX1. In PCa lung metastases genes associated with immunogenic responses were upregulated while genes associated with epithelial-mesenchymal transition were down-regulated. We also showed that CXCR3/CXCL10 axis plays a significant role in prostate cancer lung metastases in comparison to bone metastases. In this study, we comprehensively explored transcriptomic alterations in PCa lung metastases in comparison to primary PCa and PCa bone metastases. In PCa lung metastases genes associated with immunogenic responses are upregulated while genes associated with epithelial-mesenchymal transition are down-regulated. This points to a more immunogenic phenotype of PCa lung metastases thus potentially making patients more susceptible to immunotherapeutic approaches. - Source: PubMed
Publication date: 2024/08/15
Saraji AlirezaWulf KatharinaStegmann-Frehse JanineKang DuanOffermann AnneJonigk DannyKuehnel Mark PhilippKirfel JuttaPerner SvenSailer Verena Wilbeth