Agrp
- Known as:
- Agrp
- Catalog number:
- 043845A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Agrp
Related genes to: Agrp
- Gene:
- AGRP NIH gene
- Name:
- agouti related neuropeptide
- Previous symbol:
- -
- Synonyms:
- Agrt, ART, ASIP2
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-22
- Date modifiied:
- 2016-10-05
Related products to: Agrp
Related articles to: Agrp
- During pregnancy mammals increase their food intake to accommodate the elevated metabolic demands associated with fetal growth and development. However, the molecular and neural circuit mechanisms mediating increased feeding during pregnancy are largely unknown. Here, we demonstrate that arcuate nucleus agouti-related peptide (AgRP) neurons are activated and pro-opiomelanocortin (POMC) neurons are inhibited during pregnancy in mice. These changes are acutely required for promoting hyperphagia during pregnancy as chemogenetic inhibition of AgRP neurons or activation of POMC neurons both reduced the feeding of pregnant mice to non-pregnant levels. Finally, we utilized single cell resolution spatial transcriptomics in the arcuate nucleus of non-pregnant and pregnant mice to characterize pregnancy-induced changes in the transcriptomic state of arcuate nucleus neurons, including significant changes in many neurons controlling energy homeostasis, including AgRP and POMC neurons. Together, these findings outline a circuit mechanism regulating increased feeding during pregnancy, providing important mechanistic insights related to conditions at the intersection of reproduction and metabolism. - Source: PubMed
Publication date: 2026/07/17
Possa-Paranhos Ingrid CamilaCatalbas KeremCongdon SamuelCho DajinPattnaik TanyaNelson ChristinaPathak AaravPatel VrajSweeney Patrick - Glucocorticoids (GCs) are key regulators of energy homeostasis. Clinically, patients with Cushing's syndrome exhibit obesity, whereas adrenal insufficiency is associated with weight loss. However, circulating biomarkers reflecting GC action have not been established. Agouti-related protein (AgRP), an orexigenic neuropeptide, is upregulated by GC in the rodent hypothalamus. Here, we investigated whether AgRP is a surrogate marker of GC action through in vitro and in vivo experiments as well as a clinical study. - Source: PubMed
Publication date: 2026/07/15
Aoyama NatsukiNishiyama MitsuruIwasaki YasumasaNakayama ShuichiOkazaki MizuhoTaguchi TakafumiTsuda MasayukiHashimoto KoshiMakino ShinyaFujimoto Shimpei - - Source: PubMed
Zhang Yan - - Source: PubMed
Detomas MarioDischinger Ulrich - An appropriate stress response is essential for properly responding to, coping with, and subsequently recovering from disturbing environmental stimuli. However, how the brain dynamically encodes the scalability of stress responses remains poorly understood. Here, we found that, GABAergic neurons in the arcuate nucleus (Arc, denoted as Arc neurons) send direct inputs to corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (PVH, denoted as PVH neurons), the primary regulators of the hypothalamic-pituitary-adrenal (HPA) axis. Although PVH neurons exhibited time-locked activation in response to various environmental stressors, both GABA release onto PVH neurons and the activity of PVH-projecting Arc neurons were selectively reduced during exposure to prolonged, high-intensity stressors, but not following exposure to transient, low-intensity stressors. Notably, GABA release onto PVH neurons was positively correlated with PVH-projecting Arc neuron activity, yet anticorrelated with PVH neuronal activity in response to the same prolonged, high-intensity stressors. Selective silencing of PVH projecting Arc neurons was sufficient to elevate HPA axis activity and stress levels, phenocopying the effect of direct of PVH neuron activation. Conversely, selective activation of PVHprojecting Arc neurons reduced both HPA axis activity and stress levels, this effect was completely abolished by concurrent excitation of PVH neurons. Molecular identity screening further revealed that these PVH-projecting Arc neurons are not subsets expressing agouti-related peptide (AgRP) and tyrosine hydroxylase (TH) markers. Collectively, these findings indicate that the non-AgRP/TH Arc→PVH neurocircuit serves as a critical neural substrate that directly encodes the scalability of stress responses to environmental stressors by modulating inhibitory GABA release in a stimulus intensity-dependent manner. - Source: PubMed
Publication date: 2026/07/02
Cao YuhanSeese Megumi HJiang ZhiyingSu CunjinYang MaojieDo Monte Fabricio HTong QingchunXu Yuanzhong