Dgcr8
- Known as:
- Dgcr8
- Catalog number:
- 037626A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Dgcr8
Related genes to: Dgcr8
- Gene:
- DGCR8 NIH gene
- Name:
- DGCR8 microprocessor complex subunit
- Previous symbol:
- C22orf12
- Synonyms:
- DGCRK6, Gy1, pasha
- Chromosome:
- 22q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 2000-06-29
- Date modifiied:
- 2019-01-25
Related products to: Dgcr8
Related articles to: Dgcr8
- Silicosis, one of the most common and severe forms of pneumoconiosis, remains a major occupational health concern worldwide. Given the lack of effective therapies, understanding the underlying molecular mechanisms is urgently needed. Here, we report that ALKB homolog 1 (ALKBH1), an N6-methyladenosine (mA) demethylase, is upregulated in silica-induced pulmonary fibrosis and plays a pro-fibrotic role. The antifibrotic peptide Ac-SDKP inhibited Alkbh1 expression and alleviated pulmonary fibrosis. Mechanistically, ALKBH1 suppressed the biosynthesis of miR-129-5p by removing mA modification from pri-miR-129-5p, thereby reducing DGCR8-mediated processing and leading to decreased mature miR-129-5p levels. Ac-SDKP reversed this process, restoring miR-129-5p expression. Functionally, overexpression of miR-129-5p attenuated silica-induced pulmonary fibrosis by suppressing macrophage activation. Collectively, these findings identify the Ac-SDKP-ALKBH1-miR-129-5p axis as a critical regulatory mechanism, with ALKBH1-mediated mA demethylation of pri-miR-129-5p representing a key node and a promising therapeutic target for silicosis. - Source: PubMed
Li QianDu JiakunYi XueLi ShifengYang YiWang XinyuXu ZelinJin FuyuLi TianLi YaqianXu DingjieWei ZhongqiuCai WenchenMao NaZhang LijuanYu XiaoShi YiweiYang FangXu HongGao Xuemin - Overcoming chemoresistance is a major therapeutic challenge to improve patient's outcome, and lncRNAs are involved in the carcinogenesis and progression of NSCLC. Accordingly, this study was aimed to explore the roles and functions of lncRNA FENDRR in the progression and drug resistance of NSCLC. - Source: PubMed
Publication date: 2026/04/15
Wang Yuan-JinLiu Xiang-MingLi Shu-YuanLv Meng-WeiWang QiaoZhang Hao - Molecular biomarkers are increasingly used for risk stratification, particularly in up-front surgery settings (Children's Oncology Group trials), whereas in preoperative chemotherapy setting, the ongoing International Society of Pediatric Oncology (SIOP)-Renal Tumor Study Group-2016 UMBRELLA study aims to validate selected biomarkers for future risk-adapted treatment strategies. This systematic review summarizes all literature on the prognostic value of these biomarkers. - Source: PubMed
Publication date: 2026/05/18
Oller AgustinaKemmeren PatrickPerotti Danielavan Tinteren HarmVerschuur ArnauldSpreafico FilippoBrok JesperFurtwängler Rhoikos C JChowdhury TanzinaAl-Saadi ReemVujanic Gordan MTreece Amy LDrost Jarnovan Grotel MartineMullen Elizabeth AEvageliou Nicholas FGraf NorbertHong Andrew LGessler ManfredGeller James Ivan den Heuvel-Eibrink Marry M - Cardiac fibrosis is a pivotal pathological process driving adverse cardiac remodeling and a defining feature of end-stage heart disease. Nicotine, a principal constituent of tobacco products, is now recognized as an independent risk factor for cardiovascular disease. However, its direct effects on cardiac fibroblasts (CFs) biology and the molecular mechanisms underlying nicotine-induced cardiac fibrosis remain incompletely understood. - Source: PubMed
Publication date: 2026/04/27
Wu Hui-HuiLi Yue-YanMeng Fan-LiangDu Jia-MinZheng YanSong Chun-HongLi Li-MingLi YingSu Guo-Hai - Pluripotent stem cell (PSC) differentiation is orchestrated by intricate autocrine and paracrine signaling networks. Among these, exosomes, key components of the cellular secretome, are implicated as crucial mediators of intercellular communication via delivery of bioactive molecules, including microRNAs (miRNAs). This study investigated the role of exosomal miRNAs in stem cell differentiation using -deficient mouse embryonic stem cells (mESCs), which are incapable of producing mature miRNAs. Although the differentiation capacity was markedly impaired in these cells, partial restoration was observed following treatment with exosomes derived from differentiating wild-type mESCs. Exosomal miRNA uptake was confirmed, and gene ontology analysis revealed significant enrichment of pathways associated with cell fate determination, morphogenesis, and apoptosis regulation. Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that exosomal miRNAs modulated multiple osteoinductive signaling cascades, notably the MAPK and TGF-β pathways, in Dgcr8-deficient cells. Apoptotic markers were also downregulated, suggesting a protective effect conferred by the exosomal cargo. Collectively, our results suggest that exosome-mediated delivery of miRNAs may represent a fundamental mechanism by which pluripotent stem cells coordinate stress responses and differentiation trajectories, providing novel insights into the regulation of embryogenesis. - Source: PubMed
Publication date: 2026/03/25
Ha Tae-WonKim Hyun KyuNo DongyueLee Jeong BinKim AhyeonKim BomiSong YenaChoijamts MunkhzulChoi YoungsokLee MihyeLee Man Ryul