Alkaline phosphatase _ ALPL
- Known as:
- Alkaline phosphatase _ ALPL
- Catalog number:
- NB100-62323
- Product Quantity:
- 0.2 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- Alkaline phosphatase _ ALPL
Related genes to: Alkaline phosphatase _ ALPL
- Gene:
- ALPL NIH gene
- Name:
- alkaline phosphatase, biomineralization associated
- Previous symbol:
- HOPS
- Synonyms:
- TNSALP, TNALP, TNAP
- Chromosome:
- 1p36.12
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2018-08-08
Related products to: Alkaline phosphatase _ ALPL
Alkaline Phosphatase Conjugated Affinity Purified anti-Swine IgG (H&L) [Goat] Secondary_Antibodies Alkaline Phosphatase Conjugated Affinity Purified anti_Swine IgG (H&L) [Goat]1-step Polymer HISTO STAT Alkaline Phosphatase Fast Red kit for IHC staining of Mouse & Rabbit & Rat primary antibodies, 900 slides plus (large size1-step Polymer HISTO STAT Alkaline Phosphatase Fast Red kit for IHC staining of Mouse & Rabbit & Rat primary antibodies, 350 plus slides (small size1-step Polymer HISTO-STAT Alkaline Phosphatase multivalant (Secondary Reagent Component) for staining Mouse, Rabbit & Rat primary antibodies, 350 pl1-step Polymer HISTO-STAT Alkaline Phosphatase multivalant (Secondary Reagent Component) for staining Mouse, Rabbit & Rat primary antibodies, 900 plu105 kDa islet cell antigen,BEM-3,Brain-enriched membrane-associated protein tyrosine phosphatase,ICA105,PTP IA-2,PTPLP,Ptprn,Rat,Rattus norvegicus,Receptor-type tyrosine-protein phosphatase-like N,R-P12 Lipoxygenase antibody (Alkaline Phosphatase)12 Lipoxygenase antibody (Alkaline Phosphatase)130 kDa myosin-binding subunit of smooth muscle myosin phophatase,Chicken,Gallus gallus,MBS,Myosin phosphatase target subunit 1,Myosin phosphatase-targeting subunit 1,MYPT1,PP1M subunit M110,PPP1R12A,14 kDa phosphohistidine phosphatase,Bos taurus,Bovine,Phosphohistidine phosphatase 1,PHP14,PHPT114 kDa phosphohistidine phosphatase,CGI-202,Homo sapiens,HSPC141,Human,Phosphohistidine phosphatase 1,PHP14,PHPT1,Protein janus-A homolog14 kDa phosphohistidine phosphatase,Mouse,Mus musculus,Phosphohistidine phosphatase 1,Php14,Phpt114 kDa phosphohistidine phosphatase,Oryctolagus cuniculus,Phosphohistidine phosphatase 1,PHP,PHP14,PHPT1,Protein histidine phosphatase,Rabbit14 kDa phosphohistidine phosphatase,Phosphohistidine phosphatase 1,PHP14,PHPT1,Pig,Sus scrofa Related articles to: Alkaline phosphatase _ ALPL
- Jinfeng pills (JFP), a well-known traditional Chinese medicine (TCM) consisted of 9 herbs, benefit Qi, nourish the blood, effectively regulate the menstrual cycle, promote ovulation and improve endometrial thickness and blood flow. Previous studies have shown that JFP has certain effect on premature ovarian insufficiency (POI). In this prospective cohort study, the effect and mechanisms of JFP on the outcomes of in vitro fertilization and embryo transfer (IVF-ET) in poor ovarian response(POR) was investigated. - Source: PubMed
Publication date: 2026/07/18
Kong XumeiLuo QianwenHuang TianhongChen FuruiZhang YananXiong DongshengQiu YuLai WeiYan XiaoyanLong FangyiGong Yan - Alkaline phosphatase (ALP) plays an essential role in skeletal mineralization and bone metabolism. While elevated ALP levels are commonly investigated in clinical practice, persistently low ALP values are often overlooked despite their potential association with hypophosphatasia (HPP), a rare metabolic bone disorder caused by pathogenic variants in the ALPL gene. This study aimed to determine the prevalence and clinical characteristics of adults with persistently low ALP in a large tertiary care hospital. - Source: PubMed
Publication date: 2026/07/18
Alshahrani FahadAlsuliman SaraAlkalefah ReemaAlmutairi ShadenAleidi YaraAlmohaya Mohammed - Skeletal aging involves pyrophosphate/phosphate disequilibrium and impaired mechanotransduction, which together constrain osteogenic repair. We develop OsteoVes, a matrix-vesicle-mimetic extracellular organelle that combines tissue-nonspecific alkaline phosphatase (ALP)-mediated inorganic pyrophosphate (PPi) hydrolysis, nano-hydroxyapatite nucleation, and a mesenchymal stem cell-derived membrane interface for extracellular matrix anchoring. In aged human mesenchymal stem/stromal cells (MSCs), OsteoVes restores the Pi/PPi set point, suppresses PPARG activity, promotes RUNX2 nuclear translocation, and supports osteogenic differentiation. OsteoVes also increases actomyosin tension and engages an ITG/FAK-PIEZO1-JNK/c-JUN-RUNX2 mechanotransduction-associated pathway. In elderly osteopenic/osteoporotic patient-derived MSCs, OsteoVes supports ALP activity and matrix mineralization. Systemic administration improves trabecular microarchitecture and mechanical properties in naturally aged mice within 4 weeks, remains active in Alpl progeroid mice, and elicits osteoanabolic serum and imaging responses without evident short-term toxicity in metabolically aged rhesus macaques. These findings identify matrix vesicle (MV) dysfunction as an extracellular osteometabolic control point for short-term chemo-mechanical rescue. - Source: PubMed
Publication date: 2026/07/16
Zhang LiqiangWei XiaoZhang KeDing FanGuo ZiliangZou BinHe WangxiaoLiu Wenjia - Aging is among the major risk factors for male infertility. Coridius chinensis is a traditional Chinese insect medicine that has been utilized to improve male reproduction in China for hundreds of years, but elucidation of the underlying mechanisms involved remains challenging. - Source: PubMed
Publication date: 2026/07/08
Zhang MeiZeng FengyinLou HuixianMa JingHou Xiaohui - Hypophosphatasia (HPP) is a rare metabolic disorder caused by loss-of-function ALPL variants and characterized by heterogeneous skeletal and extra-skeletal manifestations. Although recent diagnostic criteria include ALPL variants, the diagnosis can be made based solely on clinical features. In adult-onset HPP, however, symptoms are often mild or nonspecific, including musculoskeletal symptoms and fatigue, making it difficult to differentiate from other conditions. This retrospective, cross-sectional study aimed to integrate genetic and biochemical data to enhance the clinical interpretation of low alkaline phosphatase (ALP) in patients with bone disorders. Among 865 consecutive adults visiting a bone-specialized outpatient department, patients with persistent hypophosphatasemia underwent ALPL sequencing. Clinical and biochemical characteristics were compared among three groups: biallelic or monoallelic variants with dominant-negative effect (DNE), monoallelic variants without DNE, and variant-negative individuals. Fifty-six patients (6.5%) showed persistent hypophosphatasemia. Two (0.2%) were compound heterozygotes, and 29 (3.4%) carried monoallelic variants without DNE. Clinical symptoms and secondary causes of hypophosphatasemia were similar between monoallelic without DNE and variant-negative patients, whereas serum ALP, urinary phosphoethanolamine (PEA), and plasma inorganic pyrophosphate (PPi) differed significantly. A model using thresholds of ALP < 35 IU/L, urinary PEA > 91 µmol/gCr, and plasma PPi > 1.96 µmol/L demonstrated high diagnostic performance for identifying patients with monoallelic variants without DNE. This study elucidated the complex clinical spectrum of patients with low ALP. Although clinical manifestations were comparable between monoallelic individuals without DNE and variant-negative individuals, distinct biochemical profiles were observed. Integrating genetic nosology into current diagnostic criteria may refine clinical decision-making. - Source: PubMed
Publication date: 2026/07/15
Hidaka NaokoKimura SoichiroWatanabe SoAkiyama TomoyukiTachikawa KanakoMichigami ToshimiAdachi NatsuhoIrie KokiHoshino YoshitomoKato HajimeNangaku MasaomiTanaka SakaeMakita NorikoSaito TakuIto Nobuaki