C7orf61
- Known as:
- C7orf61
- Catalog number:
- 003279A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- C7orf61
Related genes to: C7orf61
- Gene:
- C7orf61 NIH gene
- Name:
- chromosome 7 open reading frame 61
- Previous symbol:
- -
- Synonyms:
- IMAGE:4839025
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2008-07-18
- Date modifiied:
- 2016-12-01
Related products to: C7orf61
Related articles to: C7orf61
- Milk protein content represents a key economic trait in dairy production, yet the genetic architecture underlying this trait remains unexplored in Romanian dual-purpose cattle breeds. This study conducted a genome-wide association analysis for milk protein content in 313 Romanian Simmental (n = 271) and Romanian Brown (n = 42) cows belonging to the Research and Development Station for Bovine Arad, Romania. Following quality control, 33,531 SNPs were tested for association with protein percentage adjusted for other effects (breed, days in milk, season, year, parity) using linear regression with the first five principal components as covariates to control population stratification. Although no SNP reached genome-wide significance ( < 5 × 10), one SNP achieved significance ( < 2.98 × 10) and seven additional SNPs exceeded the nominal threshold ( < 1 × 10) across six chromosomes. The strongest association ( = 9.56 × 10) mapped to chromosome 25 near . Biologically relevant candidate genes included on chromosome 13, previously associated with milk traits in Chinese Holstein, and on chromosome 3, involved in calcium homeostasis. These findings provide initial insights into genomic regions influencing milk protein content in Romanian dual-purpose cattle, though validation in larger cohorts needs to be carried out. - Source: PubMed
Publication date: 2025/10/26
Bratu Daniel GeorgeBlaga ȘerbanZanfira Bianca CorneliaMircu CălinSpătaru Ioana IrinaTorda IuliuMizeranschi Alexandru EugeniuIlie Daniela ElenaCziszter Ludovic TomaVizitiu Dorin AlexandruBoldura Oana MariaHuțu Ioan - Chromosome 7 open reading frame 61 (C7orf 61) was a testis-specific gene, and may be involved in the process of spermatogenesis. This study aimed to investigate the expression of C7orf61 in the testis and determine its role in spermatogenesis. - Source: PubMed
Publication date: 2024/10/12
Wu YongZhang ZengHe ChihuaDeng Qiong - Globozoospermia is a genetic syndrome characterized by the presence of round-headed spermatozoa and infertility due to the inability of these spermatozoa to fertilize the oocyte. In this article, we present the clinical case of a young globozoospermic patient with a new, not yet described mutation of the gene. We also performed a systematic review of the literature on gene mutations, the outcome of assisted reproductive techniques, and the risk of transmission of abnormalities to the offspring in patients with globozoospermia and made recommendations to offer a more appropriate clinical management of these patients. - Source: PubMed
Publication date: 2022/07/06
Crafa AndreaCondorelli Rosita AngelaLa Vignera SandroCalogero Aldo EugenioCannarella Rossella - Spermatogenesis is a complex process of cellular division and differentiation that begins with spermatogonia stem cells and leads to functional spermatozoa production. However, many of the molecular mechanisms underlying this process remain unclear. Single-cell RNA sequencing (scRNA-seq) is used to sequence the entire transcriptome at the single-cell level to assess cell-to-cell variability. In this study, more than 33,000 testicular cells from different scRNA-seq datasets with normal spermatogenesis were integrated to identify single-cell heterogeneity on a more comprehensive scale. Clustering, cell type assignments, differential expressed genes and pseudotime analysis characterized 5 spermatogonia, 4 spermatocyte, and 4 spermatid cell types during the spermatogenesis process. The UTF1 and ID4 genes were introduced as the most specific markers that can differentiate two undifferentiated spermatogonia stem cell sub-cellules. The C7orf61 and TNP can differentiate two round spermatid sub-cellules. The topological analysis of the weighted gene co-expression network along with the integrated scRNA-seq data revealed some bridge genes between spermatogenesis's main stages such as DNAJC5B, C1orf194, HSP90AB1, BST2, EEF1A1, CRISP2, PTMS, NFKBIA, CDKN3, and HLA-DRA. The importance of these key genes is confirmed by their role in male infertility in previous studies. It can be stated that, this integrated scRNA-seq of spermatogenic cells offers novel insights into cell-to-cell heterogeneity and suggests a list of key players with a pivotal role in male infertility from the fertile spermatogenesis datasets. These key functional genes can be introduced as candidates for filtering and prioritizing genotype-to-phenotype association in male infertility. - Source: PubMed
Publication date: 2021/09/27
Salehi NajmehKarimi-Jafari Mohammad HosseinTotonchi MehdiAmiri-Yekta Amir - Globozoospermia is a rare phenotype of primary male infertility inducing the production of round-headed spermatozoa without acrosome. Anomalies of DPY19L2 account for 50-70% of all cases and the entire deletion of the gene is by far the most frequent defect identified. Here, we present a large cohort of 69 patients with 20-100% of globozoospermia. Genetic analyses including multiplex ligation-dependent probe amplification, Sanger sequencing and whole-exome sequencing identified 25 subjects with a homozygous DPY19L2 deletion (36%) and 14 carrying other DPY19L2 defects (20%). Overall, 11 deleterious single-nucleotide variants were identified including eight novel and three already published mutations. Patients with a higher rate of round-headed spermatozoa were more often diagnosed and had a higher proportion of loss of function anomalies, highlighting a good genotype phenotype correlation. No gene defects were identified in patients carrying < 50% of globozoospermia while diagnosis efficiency rose to 77% for patients with > 50% of globozoospermia. In addition, results from whole-exome sequencing were scrutinized for 23 patients with a DPY19L2 negative diagnosis, searching for deleterious variants in the nine other genes described to be associated with globozoospermia in human (C2CD6, C7orf61, CCDC62, CCIN, DNAH17, GGN, PICK1, SPATA16, and ZPBP1). Only one homozygous novel truncating variant was identified in the GGN gene in one patient, confirming the association of GGN with globozoospermia. In view of these results, we propose a novel diagnostic strategy focusing on patients with at least 50% of globozoospermia and based on a classical qualitative PCR to detect DPY19L2 homozygous deletions. In the absence of the latter, we recommend to perform whole-exome sequencing to search for defects in DPY19L2 as well as in the other previously described candidate genes. - Source: PubMed
Publication date: 2020/10/27
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