C6orf173
- Known as:
- C6orf173
- Catalog number:
- 003210A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- C6orf173
Related genes to: C6orf173
- Gene:
- CENPW NIH gene
- Name:
- centromere protein W
- Previous symbol:
- C6orf173
- Synonyms:
- CUG2
- Chromosome:
- 6q22.32
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-26
- Date modifiied:
- 2015-08-24
Related products to: C6orf173
Related articles to: C6orf173
- Depression-related liability is frequently accompanied by reduced physical function, yet the shared genetic architecture linking mood-related traits and physical-function decline remains incompletely characterized. We applied genomic structural equation modeling to European-ancestry GWAS summary statistics for five constituent phenotypes: depressive symptoms, depression diagnosis, grip strength, appendicular lean mass, and walking pace. A Depression-Physical Function shared genetic factor was constructed as a cross-trait genetic covariance dimension and evaluated using LDSC-based validation and leave-one-trait-out sensitivity analyses. We then performed factor GWAS, FUMA locus annotation, Bayesian fine-mapping, MAGMA gene-based analysis, transcriptome-wide association analysis, pathway enrichment, CELLECT/MAGMA cell-type specificity analysis, partitioned heritability analysis, and gsMap spatial transcriptomic mapping. The shared factor showed good model fit and retained 755,397 quality-controlled variants for downstream analysis. The factor was positively genetically correlated with depression-related traits and negatively correlated with physical-function-related traits. FUMA identified 245 genome-wide significant SNPs, 44 lead SNPs, and 38 genomic risk loci, with 127 positional mapped genes. Fine-mapping prioritized one high-confidence locus. MAGMA identified 19 Bonferroni-significant genes and 326 FDR-significant genes, while TWAS identified 322 FDR-significant expression-associated genes. Integrating FUMA positional mapping, MAGMA gene-level association and TWAS expression-level association prioritized eight convergent genes: TMEM106B, CENPW, DRD2, LRFN5, NCAPG, DCAF16, SGIP1, and FAM120A. Functional enrichment highlighted postsynaptic structure, neuron spine, synaptic plasticity, and synapse organization. CELLECT/MAGMA prioritized brain non-myeloid neurons and glial populations, with additional endocrine-metabolic and immune-hematopoietic signals. Spatial transcriptomic mapping localized top signals to brain and spinal cord regions in the embryonic neuro-muscle reference. Partitioned heritability analysis showed enrichment in conserved, intronic, promoter, and chromatin-related genomic annotations. These findings support a shared polygenic covariance dimension linking depression-related liability with reduced physical-function-related genetic propensity. Downstream analyses prioritized candidate loci, genes, and biological contexts, with enrichment patterns consistent with neuronal, synaptic, and regulatory genomic processes. - Source: PubMed
Publication date: 2026/07/16
Zeng WenYang XiupengXu Yonggang - Cervical cancer (CC) remains a leading cause of cancer-related mortality among women, and advances in its therapeutic approaches are disappointing, in which novel therapies and precise experimental approaches are needed to be exploited. This study intends to explore the effects and involved molecular mechanism of Stichopus japonicus acidic mucopolysaccharide (SJAMP) on CC progression. CCK8 and EdU assays were utilized to test the ability of cell proliferation. Colony formation, transwell, flow cytometry assays were applied to detect cell colonies, migration, invasion, and apoptosis accordingly. RT-qPCR and western blot were used to quantify the expression levels of transcription factor AP-2 Alpha (TFAP2A) and centromere protein W (CENPW), respectively. JASPAR website, ChIP-qPCR, and dual-luciferase reporter assay were used to verify the binding loci of TFAP2A on the promoter region of CENPW. Xenograft tumor models were produced to confirm the effects of CENPW silence or SJAMP treatment in CC. SJAMP suppressed malignant phenotypes of CC cells in a dosage-dependent manner. Besides, SJAMP regulated the biological behaviors of CC cells via regulating TFAP2A expression, which further regulated CENPW expression as its transcription factor. The expression of CENPW was elevated in CC and positively correlated with TFAP2A, and the silence of CENPW hampered tumor growth in vivo. In addition, CENPW overexpression abolished the repressed cell malignant activities induced by TFAP2A silence. Xenograft tumor models proved that SJAMP curbed tumor growth in vivo via repressing TFAP2A-mediated CENPW expression. Our research revealed that SJAMP exerted its anti-tumor effects via decreasing TFAP2A-mediated CENPW expression in CC. - Source: PubMed
Publication date: 2026/07/24
Cai ZhengxiangLiu DachunHe YongpengFang ZhanglanYang HuguangLan XiaHe MiaoXian YiGong Juan - The difference in molecular characteristics of Triple negative breast cancer (TNBC) aids in distinguishing between its four prominent subtypes- basal-like 1, basal-like 2, mesenchymal, and luminal androgen receptor. This study presents the first integrative framework that combines explainable AI with machine learning approaches to classify TNBC subtypes. Unlike conventional models, our approach offers interpretability while enabling biomarker prioritization by identifying key hub genes that drive subtype-specific predictions. - Source: PubMed
Publication date: 2026/02/22
L Biji CPatel TruptiCharan DevyaniSinha Mangalam GoutamS RupaakJain MedhanshBhardwaj AshutoshGupta AnnanyaJ DheebaK AthiraMishra AnkitaMishra Deepak - The histone-fold domain (HFD) is a conserved protein interaction module that requires stabilization through a handshake interaction with an HFD partner. All HFD proteins known to date form obligate dimers to shield the extensive hydrophobic residues along the HFD. Here, we find that the lepidopteran kinetochore protein CENP-T is soluble as a monomer. We attribute this stability to a structural rearrangement, which leads to the repositioning of the HFD helix α3. This brings a conserved two-helical extension closer to the histone fold, where it takes over the position and function of the CENP-T partner CENP-W. This change has no effect on the DNA-binding ability of the lepidopteran CENP-T. Our analysis suggests that the monomeric HFD originated in the last common ancestor of insects, with a possible second independent origin in Acariformes, both of which lack CENP-W. Our study highlights an unexpected structural variation in a protein module as conserved and optimized as the HFD, providing a unique perspective on the evolution of protein structure and the forces driving it. - Source: PubMed
Publication date: 2025/10/29
Sankaranarayanan Sundar RamUlmer JonathanMørch AnnaAli-Ahmad AhmadSekulić NikolinaDrinnenberg Ines Anna - Infertility remains a prevalent global health concern, with Premature Ovarian Insufficiency (POI) and Recurrent Spontaneous Abortion (RSA) being common causes of female infertility. - Source: PubMed
Publication date: 2025/09/29
Chen ChenZhang XinyueLi WenxinLiu YueqinZhao DanZhang SuboZhu Xiaolan