C6orf81
- Known as:
- C6orf81
- Catalog number:
- 003165A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- C6orf81
Related genes to: C6orf81
- Gene:
- ARMC12 NIH gene
- Name:
- armadillo repeat containing 12
- Previous symbol:
- C6orf81
- Synonyms:
- FLJ25390
- Chromosome:
- 6p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-19
- Date modifiied:
- 2014-11-18
Related products to: C6orf81
Related articles to: C6orf81
- Previous studies have established that biallelic variants in armadillo repeat containing 12 () can lead to multiple midpiece abnormalities and asthenozoospermia. This study aims to characterize a homozygous variant associated with multiple morphological abnormalities of the sperm flagella (MMAF), and to evaluate its impact on the sperm ultrastructure and intracytoplasmic sperm injection (ICSI) outcomes. - Source: PubMed
Publication date: 2026/03/10
Xue YuYang JieQiao SenShi Shengjia - Neuroblastoma (NB) is a predominant extra-cranial malignancy in childhood, while molecular drivers of its progression and effective treatment strategies have yet to be clarified. RNA sequencing was performed to identify transcriptional regulators and corresponding target genes. To explore the biological effects and underlying mechanisms of these regulators, a comprehensive methodology was utilized, encompassing chromatin immunoprecipitation, dual-luciferase reporter assay, qRT-PCR, western blot, alongside gene over-expression and silencing techniques, co-immunoprecipitation, and mass spectrometry. The MTT assay, soft agar colony formation, Matrigel invasion, and nude mouse xenograft models were applied to assess oncogenic properties. Patient survival was analyzed using the log-rank test. Armadillo repeat containing 12 (ARMC12) was identified as a MYC-interacting modulator within liquid condensates to up-regulate critical nucleoporin-encoding targets (//), which promoted nuclear pore complex (NPC) biogenesis to facilitate nuclear trafficking of oncogenic effectors, thereby enhancing invasion and metastasis of NB. As a protein within extracellular vesicles of colonizing NB tissues, MGL_0381 also facilitated MYC transactivation via physical interaction to accelerate NPC biogenesis and NB progression. Tioconazole (TCZ) and UU-T02 were identified as efficient inhibitors blocking ARMC12-MYC and MGL_0381-MYC interaction, and synergistically reduced NPC number and aggressive features of NB. High , , , , or levels served as markers of unfavorable patient outcomes in clinical cohorts. These findings collectively demonstrate that dual targeting of AMRC12 and disrupts MYC liquid condensates-driven NPC biogenesis during NB progression. - Source: PubMed
Publication date: 2026/01/01
Hu AnpeiYang ChunhuiWang ZhijieWang XiaolinLi XinyueZhou ShunchenZhao BosenQu JiayingWang XiaojingZheng LiduanTong Qiangsong - Cohorts of individuals that have been genotyped and phenotyped for genomic selection programs offer the opportunity to better understand genetic variation associated with complex traits. Here, we performed an association study for traits related to body size and muscular development in intensively selected beef cattle. We leveraged multiple trait information to refine and interpret the significant associations. - Source: PubMed
Publication date: 2023/11/28
Gualdrón Duarte José LuisYuan CanGori Ann-StephanMoreira Gabriel C MTakeda HarukoCoppieters WouterCharlier CaroleGeorges MichelDruet Tom - Male infertility is a multifactorial reproductive health problem with complex causes. Non-obstructive azoospermia (NOA) is characterized by failure of spermatogenesis, leading to the absence of spermatozoa in ejaculates. The molecular mechanism underlying the NOA is still not well understood. - Source: PubMed
Publication date: 2023/08/04
Alagundagi Dhananjay BGhate Sudeep DShetty PrasannakumarGollapalli PavanShetty PraveenkumarPatil Prakash - Obstructive sleep apnea (OSA) has been associated with psychiatric disorders, especially depression and posttraumatic stress disorder (PTSD). genetic variants have been previously reported to confer the risk of depression and PTSD. This study aimed to investigate the association of single nucleotide polymorphisms (SNPs) in the gene with OSA and OSA-related quantitative traits. - Source: PubMed
Publication date: 2023/05/18
Wang AnzhaoWei ZhichengYuan HaolinZhu YaxinPeng YuGao ZhenfeiLiu YuenanShen JinhongXu HuajunGuan JianYin ShankaiLiu FengLi Xinyi