C5orf40
- Known as:
- C5orf40
- Catalog number:
- 003122A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- C5orf40
Related genes to: C5orf40
- Gene:
- FNDC9 NIH gene
- Name:
- fibronectin type III domain containing 9
- Previous symbol:
- C5orf40
- Synonyms:
- MGC27121
- Chromosome:
- 5q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-07-26
- Date modifiied:
- 2014-11-19
Related products to: C5orf40
Related articles to: C5orf40
- The study aims to explore the genetic predispositions and molecular pathways of low cardiorespiratory fitness (VO) in young Saudi females ( = 70). Young females were grouped based on the level of VO according to the specification of the physical fitness specialist certification as low VO (< 28.9; = 19) and high VO (> 33; = 14) and genotyped for 243345 putative functional exonic variants. The -rs10037485T, -rs75380747G and -rs13695C SNPs on chromosome 5, 12 and 17, respectively were found to be the most significant among young Saudi females with low VO ( < 8.01 × 10). Linkage disequilibrium (LD) analysis among the significant SNPs ( < 0.001) have revealed risk and protective haplotypes with high degree (-value < 1.0 × 10) of LD. The most significant risk haplotypes with the low VO in young Saudi females are: Chromosome 1: -rs10800201G; -rs4657537A; rs4657583T (-value = 2.00 × 10); Chromosome 3: rs978979G; -rs7637449A; -rs111934125T; -rs9835332G (-value = 5.00 × 10) and Chromosome 17: -rs13696C; -rs1901187C (-value = 1.00 × 10). Functional Enrichment Analysis revealed that the genes with SNPs < 0.001 have significantly involved in the heart rate ( = 0.00442), body weight ( = 0.00629), breath tests ( = 0.0147), proteolysis ( = 0.00623) and cardiac muscle fiber development ( = 0.0263). In conclusion we could say that the identified genetic predispositions and gene-annotation enrichment in low VO in young Saudi females revealed that they are at high risk for developing cardiovascular complications. - Source: PubMed
Publication date: 2019/06/15
Al Asoom Lubna IbrahimAlsuwat Hind SalehRafique NazishAl Makhaita MarwahAlamoudi WidyanAbdulAzeez SayedBorgio Jesu Francis - To study the cellular and molecular function of peroxisome proliferator-activated receptor γ (PPARγ) in skeletal muscle differentiation, we have generated inducible gain-of-function to overexpress PPARγ in C2C12 myoblasts. In order to identify PPARγ targets, RNA sequencing (RNA-seq) was used to evaluate and quantify the transcriptomes and expression patterns during myogenic differentiation under the overexpression of PPARγ. The formation of myotubes and the expression of muscle-specific myogenic genes such as MyoD and MyoG may be inhibited by PPARγ overexpression. Multiple genes and pathways were significantly involved in this process, including 11 genes such as Fndc9 and Slc14a1 with fundamental change of regulation modes, 9 genes of which were validated by the data of qRT-PCR. Our studies demonstrate that PPARγ would play critical roles on myoblasts differentiation, mediating crosstalk among several pathways and transcription factors. Our data is available in the Gene Expression Omnibus (GEO) database with the accession number as GSE99399. - Source: PubMed
Publication date: 2017/11/10
He KanWu GuoyingLi Wen-XingGuan DaogangLv WenwenGong MengtingYe ShoudongLu Aiping