C5orf35
- Known as:
- C5orf35
- Catalog number:
- 003117A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- C5orf35
Related genes to: C5orf35
- Gene:
- SETD9 NIH gene
- Name:
- SET domain containing 9
- Previous symbol:
- C5orf35
- Synonyms:
- MGC33648
- Chromosome:
- 5q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-10-31
- Date modifiied:
- 2014-11-19
Related products to: C5orf35
Related articles to: C5orf35
- Characterizing the transcriptomic profiles of gastrointestinal tract tissues in high-altitude pigs is crucial for understanding the molecular mechanisms underlying their metabolic adaptation to high-altitude environments. Here, we generated RNA-seq data from five gastrointestinal tract tissues (i.e., stomach, jejunum, cecum, colon, rectum) and the triceps brachii muscle of six 300-day-old castrated male Tibetan pigs (inhabiting high-altitude regions) and six Black pigs (inhabiting low-altitude regions). Pigs were group-housed and fasted for 24 h before sampling. We identified transcriptional differences between these two pig populations, revealing that genes upregulated in the gastrointestinal tract tissues and triceps brachii muscle of Tibetan pigs, compared to Black pigs, are primarily associated with immune response and metabolic processes, including lipid metabolism. Consistently, a comparative analysis demonstrated that the fatty acid content was higher in the triceps brachii muscles of Tibetan pigs than in those of Black pigs. Additionally, we identified 18 genes, including , , , and , whose expression in gastrointestinal tract tissues was significantly correlated with the metabolite abundance (amino acid and fatty acid, etc.) in the triceps brachii muscles. This study may contribute to the understanding of high-altitude adaptation mechanisms in Tibetan pigs and provides valuable insights for further genetic improvement of pig breeds. - Source: PubMed
Publication date: 2025/12/04
Ran BoTang JieWang YanTao XuanYang YuekuiYang XuemeiGong JianjunHe ZhipingGu YirenLiu PengliangLiang Yan - Butylphthalide has shown significant potential in the treatment of ischemic stroke, but its precise mechanisms of action remain unclear. Long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) play crucial roles in the pathogenesis of ischemic stroke and may serve as potential therapeutic targets. This study investigated the effects of butylphthalide treatment on the lncRNA-mRNA co-expression network in ischemic stroke patients. - Source: PubMed
Publication date: 2025/04/10
An YangfangHuang LingyunLi JunChen ZhuoCai JizhangWang BiaoZhou Qiong - To screen for the key characteristic genes of the psoriasis vulgaris (PV) patients with different Traditional Chinese Medicine (TCM) syndromes, including blood-heat syndrome (BHS), blood stasis syndrome (BSS), and blood-dryness syndrome (BDS), through bioinformatics and machine learning and to provide a scientific basis for the clinical diagnosis and treatment of PV of different TCM syndrome types. - Source: PubMed
Liu XueweiJia HuangchaoWang LiyunWang ZiwenXu MengyueLi YunfeiWang Ronghui - Histone modifications such as methylation of key lysine residues play an important role in embryonic development in a variety of organisms such as of Pacific oysters, zebrafish and mice. The action of demethylase ("erasers") and methyltransferase ("writers") enzymes regulates precisely the methylation status of each lysine residue. However, despite fishes being very useful model organisms in medicine, evolution and ecotoxicology, most studies have focused on mammalian and plant model organisms, and mechanisms underlying regulation of histones are unknown in fish development outside of zebrafish. Here, putative histone lysine demethylases (Kdm) and methyltransferases (Kmt) were identified in an isogenic lineage of the self-fertilizing hermaphroditic vertebrate, the mangrove rivulus fish, Kryptolebias marmoratus. Evolutionary relationships with other animal demethylases and methyltransferases were examined, and expression patterns during embryonic development and in adult tissues were characterized. Twenty-five Kdm orthologues (Jarid2, Jmjd1c, Jmjd4, Jmjd6, Jmjd7, Jmjd8, Kdm1a, Kdm1b, Kdm2a, Kdm2b, Kdm3b, Kdm4a, Kdm4b, Kdm4c, Kdm5a, Kdm5b, Kdm5c, Kdm6a, Kdm6b, Kdm7a, Kdm8, Kdm9, UTY, Phf2 and Phf8) and forty-eight Kmt orthologues (Ezh1, Ezh2, Setd2, Nsd1, Nsd2, Nsd3, Ash1l, Kmt2e, Setd5, Prdm1, Prdm2, Prdm4, Prdm5, Prdm6, Prdm8, Prdm9, Prdm10, Prdm11, Prdm12, Prdm13, Prdm14, Prdm15, Prdm16, Setd3, Setd4, Setd6, Setd1a, Setd1b, Kmt2a, Kmt2b, Kmt2c, Kmt2d, Kmt5a, Kmt5b, Ehmt1, Ehmt2, Suv39h1, Setmar, Setdb1, Setdb2, Smyd1, Smyd2, Smyd3, Smyd4, Smyd5, Setd7, Setd9, Dot1l) were discovered. Expression patterns of both Kdm and Kmt were variable during embryonic development with a peak in gastrula stage and a reduction in later embryogenesis. Expression of both Kdm and Kmt was higher in male brains compared to hermaphrodite brains whereas specific expression patterns of Kdm and Kmt were observed in the hermaphrodite ovotestes and male testes, respectively. Putative histone demethylases (Kdm) and methyltransferases (Kmt) were for the first time characterized in a teleost besides zebrafish, the mangrove rivulus. Their domain conservation and expression profiles suggest that they might play important roles during development, gametogenesis and neurogenesis, which raises questions about epigenetic regulation of these processes by histone lysine methylation in K. marmoratus. Due to its peculiar mode of reproduction and the natural occurrence of isogenic lineages, this new model species is of great interest for understanding epigenetic contributions to the regulation of development and reproduction. - Source: PubMed
Publication date: 2018/11/17
Fellous AlexandreEarley Ryan LSilvestre Frederic - Genome-wide association studies have revealed many breast cancer (BC) risk-associated genetic variants that might functionally interact with other molecular determinants of BC. We analysed the association of 21 known risk-associated single-nucleotide variants (SNVs) with recurrent somatic variants in two cohorts of 77 and 754 oestrogen receptor α-positive BCs. Four SNVs located at 5q11.2 were found to be associated with the somatic PIK3CA variant status in the pilot cohort of 77 cases with odds ratio (OR) up to 6.5 indicating strong effects, and were selected for the validation phase. Two of these SNVs, rs252913 and rs331499, located in the MAP3K1/SETD9 gene boundary, were confirmed to be associated with somatic PIK3CA variants in the large cohort with OR 2.97 (1.17-7.75) and 1.76 (1.11-2.77), respectively, notably higher than their BC risk-associated values, both around 1.1. In the presence of the SNV or of somatic PIK3CA variants, cancers express significantly elevated levels of MAP3K1 and SETD9, with synergy of SNV and PIK3CA variants in MAP3K1 gene overexpression, consistent with a preferential PIK3CA-dependent regulation of the variant alleles. - Source: PubMed
Publication date: 2016/12/28
Puzone RobertoPfeffer Ulrich