C5orf24
- Known as:
- C5orf24
- Catalog number:
- 003108A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- C5orf24
Related genes to: C5orf24
- Gene:
- C5orf24 NIH gene
- Name:
- chromosome 5 open reading frame 24
- Previous symbol:
- -
- Synonyms:
- FLJ37562
- Chromosome:
- 5q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-04-03
- Date modifiied:
- 2016-11-22
Related products to: C5orf24
Related articles to: C5orf24
- The circRNA-miRNA-mRNA networks of extracellular vesicles (EVs) in first-onset schizophrenia (FOS) have not been reported yet. Here, we constructed circRNA-miRNA-mRNA networks of EVs, and examined their diagnostic efficiency in FOS. - Source: PubMed
Publication date: 2025/07/09
Du XinzheHu WeiLi XinrongGao YaoLi JunxiaHu XiaodongWang XiaoZhao WentaoCheng LongCao XiaohuaCao HongbaoRen ZhiyongZhang YuXu YongLiu Sha - Stroke is a leading cause of death and disability worldwide. It is crucial to understand the influencing factors and potential mechanisms of stroke, as well as reducing its risk. This study identified the expression of the B230219D22Rik gene in mouse microglial cells, corresponding to the human gene C5orf24, using the NCBI database. We then validated the role of C5orf24 in stroke using quantitative real-time PCR, enzyme-linked immunosorbent assay, western blot and Mendelian randomization (MR) analysis. Additionally, we evaluated the causal association of C5orf24 with three other vascular diseases: coronary heart disease, myocardial infarction, and embolism. The gene B230219D22Rik and C5orf24 expressed in microglia was observed to have reduced expression in mouse and human cell stroke models, respectively. In MR analysis, we found a significant causal relationship between increased C5orf24 levels and reduced stroke risk (OR = 0.68, 95% CI 0.48-0.98, P = 4.07 × 10). However, this association was not observed in three other vascular diseases. To further explore the function of C5orf24 in stroke, we overexpressed C5orf24 in the oxygen-glucose deprivation/reperfusion (OGD/R) model of human microglial cell line clone 3 (HMC3) in vitro and found that C5orf24 inhibited the expression of inflammatory factors IL-1β and IL-6. In our study, we revealed a causal relationship between elevated levels of C5orf24 and a reduced risk of stroke through cell experiments and MR analysis, and found that inflammation might play a mediating role. This suggests that C5orf24 could be a promising drug target for stroke treatment. - Source: PubMed
Publication date: 2025/03/05
Gao RanXu YaqiZhang MinZeng QiZhu GaizhiSu WentingWang Renxi - Maintaining blood glucose homeostasis during fasting and feeding is crucial for the prevention of dysregulation that can lead to either hypo- or hyperglycaemia. Here we identified feimin, encoded by a gene with a previously unknown function (B230219D22Rik in mice, C5orf24 in humans), as a key modulator of glucose homeostasis. Feimin is secreted from skeletal muscle during feeding and binds to its receptor, receptor protein tyrosine kinase Mer (MERTK), promoting glucose uptake and inhibiting glucose production by activation of AKT. Administration of feimin and insulin synergistically improves blood glucose homeostasis in both normal and diabetic mice. Notably, a specific single nucleotide polymorphism (rs7604639, G>A) within the MERTK gene, causing an amino acid substitution (R466K) within the feimin-MERTK binding region, leads to reduced association with feimin and elevated postprandial blood glucose and insulin levels in humans. Our findings underscore a role of the feimin-MERTK signalling axis in glucose homeostasis, providing valuable insights into potential therapeutic avenues for diabetes. - Source: PubMed
Publication date: 2025/01/02
Shi XiaoliuHu XiaoFang XinleiJia LiangjieWei FangchaoPeng YingLiu MenghaoGao AiboZhao KeChen FengyiHu XiaoliHong JieNing GuangSong YongfengWang JiqiuWang Yiguo - Little knowledge of antigen existence in the pulmonary tuberculosis (PTB) patient serum impeded its development in antigen detection technology, despite its considerable potential. - Source: PubMed
Publication date: 2024/03/26
Sheng GangChu HongqianDuan HuijuanSun HongXie ZhongyaoSun ZhaogangCao Tingming - Maternal asthma in pregnancy is associated with adverse perinatal and child health outcomes; however, mechanisms are poorly understood. - Source: PubMed
Publication date: 2022/07/03
Lee Alison GTignor NicoleCowell WhitneyColicino ElenaBozack AnneBaccarelli AndreaWang PeiWright Rosalind J