C1orf186
- Known as:
- C1orf186
- Catalog number:
- 002875A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- C1orf186
Related genes to: C1orf186
- Gene:
- RHEX NIH gene
- Name:
- regulator of hemoglobinization and erythroid cell expansion
- Previous symbol:
- C1orf186
- Synonyms:
- FLJ16052
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-12
- Date modifiied:
- 2018-02-01
Related products to: C1orf186
Related articles to: C1orf186
- Long non-coding RNAs (lncRNAs) are regulatory RNA molecules involved in numerous biological processes, including immune response. Although their functions remain difficult to characterize, lncRNAs have been associated with both productive and immune traits in pigs. Because immune parameters have been proposed as indicators of immunocompetence, studying lncRNA regulation in immune-related tissues may contribute to improving pig robustness and disease resistance. In this study, whole-blood RNA-seq data from 255 commercial 60-day-old Duroc pigs were used to identify lncRNA-associated immune mechanisms. Co-expression networks were constructed from highly correlated lncRNAs and other genes, followed by functional enrichment analyses. Associations between network genes and 15 immune-related phenotypes were evaluated, and putative RNA-RNA interactions were characterized. The largest network identified was enriched for immune pathways, particularly antiviral response, and included key transcription factors such as , , , and . Four genes within this network (, ENSSSCG00000036342, , and ) were in silico predicted to interact with the same domain of lncRNA ENSSSCG00000055468. Additional networks were associated with V(D)J recombination, cytokine-mediated signalling, and other immune functions. A second putative RNA-RNA interaction was identified between lncRNA ENSSSCG00000058144 and . These findings reveal potential lncRNA-mediated regulatory mechanisms underlying porcine immunity and provide candidate RNA-RNA interactions that require future validation. - Source: PubMed
Publication date: 2026/09/17
Jové-Juncà TeodorHernández-Banqué CarlesCrespo-Piazuelo DanielGonzález-Rodríguez OlgaQuintanilla RaquelBallester Maria - Chiral fungicides constitute a substantial proportion of commonly used pesticides; however, the spread of antibiotic resistance genes (ARGs) in agricultural settings under repeated exposure to different enantiomers is still unclear. Here, the prevalence and potential risks of ARGs were investigated in the soil-earthworm ecosystem when exposed to hexaconazole (HEX) enantiomers. Metagenomic analysis indicated that R-HEX and S-HEX facilitated the dissemination of ARGs in soil without earthworms, but this effect diminished with successive exposures. Notably, S-HEX exhibited a greater effect on ARG profiles compared to R-HEX. Furthermore, HEX enantiomers, particularly S-HEX, increased the mobility potential of ARGs and enhanced host pathogenicity, thereby contributing to elevated ecological risks. Specifically, exposure to the HEX enantiomer led to an enrichment of dominant pathogenic ARG hosts, such as Enterobacteriaceae. Importantly, earthworms alleviated the enantiomer-driven dissemination of ARGs and weakened their association with mobile genetic elements (MGEs). Overall, this study offers novel perspectives on the enantiomer-driven propagation of ARGs induced by the chiral pesticide hexaconazole in soil and highlights the role of earthworms in mitigating ARG contamination. These findings contribute significantly to the risk assessment and remediation strategies for chiral pesticides. - Source: PubMed
Publication date: 2026/08/25
Shan MeiWang JiaoChen WeibinZheng ConglaiZhang LuqingYu YunlongHan LingxiFang Hua - In this study, a novel flying legged robot configuration with enhanced obstacle-crossing capability is introduced. Legged robots, especially RHex robots, already possess high obstacle-crossing capability; however, the obstacle size that can be overcome is directly dependent on the leg length. Although stair climbing-descending, obstacle course and inclined surface algorithms have been studied for the RHex robot, flight capability has not been explored. In this study, this improvement is achieved with minimal impact on the RHex's design by adding just a thruster as an additional propulsion system to propel the robot into flight. The attitude control is realized using the mass actuation of the robot legs, similar to how animals like lizards and cats utilize their limbs or tails as inertial appendages to stabilize their body pitch during mid-air maneuvers. Instead of direct and complete flight control, the aim was a temporary flight similar to obstacle-clearing flights of chickens. Hence, a nonlinear 2D model is developed to investigate the kinematics and dynamics of the RHex robot. Equations of motion are derived, linearized and used in a state feedback regulator design; the regulator is also expanded for reference tracking. - Source: PubMed
Publication date: 2026/05/08
Kutluay EmirGültekin OğuzhanYazıcıoğlu Yiğit - Intumescent cataracts complicate cataract surgery due to high intra-lenticular pressure, often causing radial tears, such as the Argentinian flag sign. The micro-Rhex-pression technique offers a precise solution for achieving safe continuous curvilinear capsulorhexis in these cases. By creating a small central puncture in the anterior capsule and using controlled decompression with capsule massage to release liquified cortex, this method effectively reduces intra-lenticular pressure and minimizes tear risks. Applied in over 1,600 cases, it achieved a 99.6% success rate with minimal complications. Compared to costly femtosecond laser capsulotomy, micro-rhex-pression is affordable, efficient, and easy to learn, making it highly accessible. This technique advances intumescent cataract management by providing a reliable, safe, and accessible approach for optimal surgical outcomes. Its straightforward approach and short learning curve make it accessible, providing surgeons with a reliable method to improve outcomes in managing challenging intumescent cataracts. This technique enhances surgical safety and accessibility, transforming the approach to such complex cataracts. - Source: PubMed
Publication date: 2025/09/25
Srivastava SudhirChandorkar DevShreeSrivastava ShivayanMoktan Devashree - Legged robots face inherent challenges in energy efficiency and stability at high speeds due to the repetitive acceleration-deceleration cycles of swing-based locomotion. To address these limitations, this paper presents a motion strategy that uses rolling gait instead of swing gait to improve the energy efficiency and stability. First, a wheel-legged quadruped robot, R-Taichi, is developed, which is capable of switching to legged, wheeled, and RHex mobile modes. Second, the mechanical structure of the transformable two-degree-of-freedom leg is introduced, and the kinematics is analyzed. Finally, experiments are conducted to generate wheeled, legged, and RHex motion in both swing and rolling gaits, and the energy efficiency is further compared. The experimental results show that the rolling motion can ensure stable ground contact and mitigate cyclic collisions, reducing specific resistance by up to 30% compared with conventional swing gaits, achieving a top speed of 0.7 m/s with enhanced stability (root mean square error (RMSE) reduction of 22% over RHex mode). Furthermore, R-Taichi exhibits robust multi-terrain adaptability, successfully traversing gravel, grass, and obstacles up to 150 mm in height. - Source: PubMed
Publication date: 2025/07/02
Xue YongjiangWang WeiDuan MingyuJiang NanqingZhang ShaoshiXiao Xuan