C1orf31
- Known as:
- C1orf31
- Catalog number:
- 002766A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- C1orf31
Related genes to: C1orf31
- Gene:
- COA6 NIH gene
- Name:
- cytochrome c oxidase assembly factor 6
- Previous symbol:
- C1orf31
- Synonyms:
- -
- Chromosome:
- 1q42.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-05
- Date modifiied:
- 2014-11-25
Related products to: C1orf31
Related articles to: C1orf31
- Coa6 controls copper delivery into the Cox2 subunit of the mitochondrial respiratory complex IV. Mutations in COA6 lead to Cox2 degradation and cause cardiomyopathy in humans. We show that decreasing the level of the mobile electron transporter cytochrome c improves both Cox2 accumulation and complex IV assembly in the budding yeast coa6-null mutant. As the heme attachment to apo-cytochrome c and the copper delivery to apo-Cox2 both require cysteine reduction, we propose that Coa6 plays a role in coordinating the maturation of Cox2 and Cytc with their cofactors. - Source: PubMed
Publication date: 2026/08/04
Dujardin GenevièveLalève AnaïsLogerais MathildePanozzo CristinaCornu DavidBourand-Plantefol AlexaChiodelli VirginieHamel PatriceBonnefoy Nathalie - Coenzyme Q10 (CoQ10) is a key mitochondrial electron carrier and a widely used dietary supplement with potential neurological benefits. However, the mechanisms underlying its effect in ameliorating memory deficits caused by cerebellar injury are not fully understood. In this study, we investigated the effects of long-term CoQ10 supplementation on working memory and the underlying mechanisms. - Source: PubMed
Publication date: 2026/04/27
Tie JingjingLi ShujiaoHuang XinRen KekeNi ZiweiLi XiaodongZhu ChangleiLiu HuiWu FeifeiYang YanlingWang Yayun - Hepatocellular carcinoma (HCC) is one of the most common and deadly malignant tumors with limited therapeutic strategies. COA6 is a mitochondria-associated protein that plays an important role in regulating tumor cuproptosis, but its role in HCC is currently unknown. In this study, we aimed to investigate the expression and potential mechanism of action of COA6 in HCC. - Source: PubMed
Publication date: 2025/09/25
Tian KailiangYang YangNiu XiaohangWei XiaomingZhang MingjinZhou YangliuYang MingyaSun HaonanZhu LixinLiu Fubao - Pancreatic ductal adenocarcinoma (PDAC) is characterised by immune hypo-responsiveness due to its complex, immunosuppressive tumour microenvironment (TME). Mitochondrial metabolic reprogramming allows PDAC cells to shift between glycolysis and oxidative phosphorylation (OXPHOS), supporting energy production and cellular viability, thus promoting tumour progression and therapeutic resistance. Mitochondrial genes associated with PDAC were identified using SMR/HEIDI analysis combined with MRC IEU OpenGWAS and GTEx V8 pancreatic eQTL databases. Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics were used to explore cellular interactions and construct spatial interaction networks. Potential small-molecule compounds targeting the TME were identified through drug prediction and molecular docking. COA6 expression was silenced in SW1990 and PANC-1 cells to assess effects on cell proliferation, migration, invasion and apoptosis. COA6, a key gene in the OXPHOS pathway, was upregulated in PDAC tumours compared to normal tissues. Functional assays showed that COA6 overexpression enhanced proliferation, migration and chemoresistance of PDAC cells. COA6 modulates OXPHOS, influences the TME and promotes drug resistance in PDAC. It is a promising therapeutic target for improving clinical outcomes in PDAC patients. Further research is needed to develop COA6-targeted therapies. - Source: PubMed
Jiang LaiJiang YuxuanZhou XuanchengWang LexinZhang ShengkeJiang ChengluMeng HuiHu QingwenGu YuhengFu YipinXu KeChi HaoZhong Xiaolin
- Source: PubMed