BST1
- Known as:
- BST1
- Catalog number:
- 002691A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- BST1
Related genes to: BST1
- Gene:
- BST1 NIH gene
- Name:
- bone marrow stromal cell antigen 1
- Previous symbol:
- -
- Synonyms:
- CD157
- Chromosome:
- 4p15.32
- Locus Type:
- gene with protein product
- Date approved:
- 1994-11-17
- Date modifiied:
- 2016-10-05
Related products to: BST1
Related articles to: BST1
- We present a thermoelectric performance enhancement by anion-cation co-doping in p-type bismuth tellurides with a cost-effective and mechanically robust thermoelectric module fabrication process. Polycrystalline (BST)(NaCl) (0 ≤ x ≤ 5.0 mol%) samples were synthesized via melting and hot-press sintering, and their anisotropic transport properties were investigated. At low NaCl concentrations, Na and Cl act as effective substitutional dopants, optimizing carrier concentration and mobility while suppressing bipolar thermal conduction via local lattice strain. At higher NaCl contents, nanoscale precipitates form, providing additional phonon scattering without degrading electronic transport. Consequently, a maximum ZT ≈ 1.49 at 350 K and an average ZT ≈ 1.4(300-425 K) were achieved. In parallel, a mechanically robust module architecture using an electrically insulating, low-thermal-conductivity PEEK support eliminates wafering and dicing processes. A 31-pair module fabricated with optimized p-type (BST)(NaCl) and n-type (CuI) Bi Te Se materials exhibit competitive thermoelectric performance to that of commercial Bi Te-based modules. These results demonstrate a pathway toward economically competitive and mechanically robust next-generation thermoelectric modules. - Source: PubMed
Publication date: 2026/08/20
Thoravat SaurabhYun Jae HyunKumar AnilPark JunyoungJin HyungyuPak ChangsunKim Young-KwangHyun Dong JinChoi Li KoonKim Yeong HunLee Hyeung JinPark JonghoPark Su DongKim Jin HeeRhyee Jong-Soo - Sepsis remains difficult to diagnose since blood culture has low sensitivity and current biomarkers lack sufficient specificity. We sought to identify robust diagnostic and therapeutic targets for neonatal sepsis through an integrated bioinformatics and experimental workflow. - Source: PubMed
Publication date: 2026/08/12
Li JunjieXiu GuanghuiLiu PingChen XianzhongZhou KailvYang Yunfeng - Alzheimer's disease (AD), Parkinson's disease (PD) and Lewy body dementia (LBD) overlap clinically, pathologically and genetically, complicating interpretation of cross-disorder genome-wide association study (GWAS) signals. - Source: PubMed
Publication date: 2026/07/02
Zhang YingZhang ZhishuaiQiu ShizhengHu Yang - Podocyte injury is a central driver of proteinuria and progressive kidney dysfunction. Although podocytes are continuously exposed to diverse stressors in both physiological and pathological contexts, the dynamic processes underlying their adaptation and eventual failure remain poorly defined. Here, we performed integrative single-nucleus RNA sequencing of kidney tissues from patients with six types of representative chronic glomerulonephritis, capturing a spectrum of podocyte injury states. We identified distinct podocyte subpopulations and reconstructed a dynamic trajectory characterized by an initial adaptive activation followed by progressive functional decline. Integration with time-resolved transcriptomics identified 778 candidate genes associated with podocyte stress responses. To distinguish putative functional drivers from secondary transcriptional changes, we integrated these candidates with a genome-wide CRISPR-Cas9 knockout screen, prioritizing genes required for podocyte survival under stress conditions. Subsequent siRNA-mediated validation of five representative candidates-BST1, TALDO1, ATP6V1E1, PPP2R1A and CHL1-showed that knockdown of these genes significantly compromised cell viability and accelerated apoptosis, highlighting a coordinated survival network spanning metabolic regulation, autophagy, and cytoskeletal stability. Our findings define a dynamic framework of podocyte stress adaptation and failure, and suggest that targeting stress-response pathways may prolong podocyte survival, thereby extending the therapeutic window for intervention in chronic kidney disease. - Source: PubMed
Publication date: 2026/07/13
Qing JianboHu JiayingWang XiaoShen XiaoyunMa YimiaoGao MingjingWu Junnan - Endothelial cells expressing the CD157 antigen (CD157 ECs) contribute to vascular regeneration and maintenance in adult tissues, but their molecular identity is not fully defined. Here, we show that CD157-positive ECs in mouse and human tissues share conserved transcriptional profiles enriched for angiogenesis-associated genes. Regulon analysis revealed a gene-regulatory network in which the NFAT pathway contributes to vascular network formation. Integration of mouse and human scRNA-seq datasets revealed human EC clusters with gene expression profiles resembling mouse CD157-positive ECs. The clusters were localized in the large vessel intima and expressed known stem-like EC markers such as BST1 (CD157), PROCR (CD201), and ABCG2. Functionally, human CD157 ECs isolated from muscle exhibited greater proliferative capacity than CD157 ECs. Cell-cell interaction analysis suggested active communication between CD157-positive ECs and surrounding cells, via the CXCL12-CXCR7 axis. Our findings identify a conserved gene signature for CD157 ECs with potential relevance for vascular regeneration. - Source: PubMed
Publication date: 2026/06/04
Iba TomohiroWakabayashi TakuIto RieSugawara AiFujimura SatoshiSawane MikaYoshioka KazuakiMatsui AyaMorishige Jun-IchiNagata NaotoIto YukinobuHorie MasafumiMaeda DaichiTanaka RicaAndo HitoshiTakakura NobuyukiNaito Hisamichi