BAI3
- Known as:
- BAI3
- Catalog number:
- 002397A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- BAI3
Related genes to: BAI3
- Gene:
- ADGRB3 NIH gene
- Name:
- adhesion G protein-coupled receptor B3
- Previous symbol:
- BAI3
- Synonyms:
- KIAA0550
- Chromosome:
- 6q12-q13
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-05
- Date modifiied:
- 2018-02-13
Related products to: BAI3
Related articles to: BAI3
- The Baicheng You Chicken is a precious indigenous breed in Xinjiang, China, prized for its strong disease and stress resistance and superior meat quality. However, the lack of scientific breeding and conservation has led to poor production performance, particularly in growth traits. In this study, we collected phenotypic and whole-genome resequencing data from 1,535 18-week-old Baicheng You Chickens (180 males and 1,355 females). After stringent quality control (SNP call rate > 95%, minor allele frequency > 1%), we constructed the breed's first comprehensive SNP-based genome-wide variation map, which comprised 2,020,743 high-quality SNPs across the genome. The filtered SNPs had high mapping quality (99.73% mapped to the bGalGal1.mat.broiler.GRCg7b reference genome, Q30 = 93.26%) and a reasonable Ti/Tv ratio (2.596), guaranteeing the reliability of subsequent analyses. We estimated genetic effects (SNP-based heritability and phenotypic variance explained (PVE) by individual loci) via the restricted maximum likelihood (REML) method, and performed a genome-wide association study (GWAS) using a mixed linear model (MLM) - with sex as a fixed effect and principal components to correct for population stratification - to identify significant loci and their effect sizes (Beta). All eight growth traits showed moderate to high heritability: body weight (BW) had the highest heritability (0.86±0.11), while chest width (CW, 0.41±0.08) and body slanting length (BSL, 0.43±0.09) were the lowest; keel length (KL), chest girth (CG), pelvic width (PW), chest depth (CD) and shank length (SL) had heritabilities of 0.50±0.09, 0.46±0.09, 0.54±0.09, 0.67±0.10 and 0.74±0.10, respectively. GWAS identified 145 significant SNPs, with a maximum Beta value of 0.39 and PVE ranging from 1.25% to 6.25%. We annotated 22 candidate genes, with TAPT1, IGF2BP1, ADGRB3, LDB2, NCAPG and LCORL as key candidates. These quantifiable genetic markers and effect estimates provide direct targets for marker-assisted selection (MAS) and valuable resources for future genomic selection (GS) programs, offering a practical approach to improve the breed's slow growth while preserving its unique meat quality. - Source: PubMed
Publication date: 2026/05/01
Jiang TinghaoYou GaoyunLi HaiyingHou ZhuochengZhao XiaoyuDong WeiLiao HerongZhang ShihaoYin Zhongtao - In transfected cells, adhesion G protein-coupled receptors (GPCRs) are activated by tethered agonists that are embedded in their canonical autoproteolytic GAIN domain. It is unknown, however, whether a tethered agonist-dependent activation mechanism generally mediates the physiological functions of adhesion GPCRs. Here, we show that G protein signaling by BAI3 (), a brain-specific adhesion GPCR, is essential for its functions in controlling axon and dendrite growth and promoting synapse formation. Moreover, our signal transduction assays confirm that constitutive exposure of BAI3's tethered agonist massively stimulates (~5-fold) its GPCR activity. However, the constitutive exposure of BAI3's tethered agonist, produced by deletion of its extracellular domains, blocked instead of activating BAI3's functions in regulating axonal and dendritic growth and promoting synapse formation. Moreover, inactivating mutations of BAI3's tethered agonist or deletion of BAI3's constituent GAIN domain did not detectably impair BAI3's physiological functions. Thus, the GPCR activity of BAI3 is functionally required, whereas tethered agonist-mediated stimulation of its GPCR activity is not. - Source: PubMed
Publication date: 2026/07/01
Wang JieMiao YiWang JinzhaoZhu ShaoyuanZhang YuWong Tsz LokYousif AhmedWernig MariusSüdhof Thomas C - The function of platelet-derived growth factor (PDGF) in the prognosis of head and neck squamous cell carcinoma (HNSCC) remains unknown. This study aims to investigate the role of PDGF in the prognosis of HNSCC and explore its potential mechanisms. - Source: PubMed
Publication date: 2026/04/26
Li YingZhou Shengfei - The GAIN domain is a hallmark of adhesion G protein-coupled receptors (aGPCRs), as this extracellular domain contains an integral agonistic sequence (Stachel) that activates the receptor by binding to its 7-transmembrane helix (7TM) domain. Many aGPCRs undergo autoproteolytic cleavage at the GPCR proteolysis site (GPS), which has a canonical H-X-S/T sequence motif located within the GPCR autoproteolysis-inducing (GAIN) domain. Here we present the crystal structure of the Hormone Receptor (HormR) and GAIN domains of ADGRB2/BAI2. The protein was not cleaved at the GPS, despite possessing an HLS sequence. Through structural comparisons and molecular dynamics (MD) simulations, we identify determinants that contribute to autoproteolytic activity beyond the H-X-S/T motif. Specifically, we highlight a T-shaped π-π interaction between the histidine base of the H-X-S/T motif and a phenylalanine residue that is highly conserved in cleavage-competent aGPCRs. This interaction is critical for properly positioning the imidazole group of the histidine to deprotonate the alcohol nucleophile. Disruption of this interaction reduces autoproteolytic activity in the ADGRL1 and introduction of the phenylalanine restores cleavage competence in the otherwise non-cleavable ADGRB3 upon expression in HEK293 cells. In addition, the poorly conserved and flexible flap regions flanking the GPS also contribute to full autocleavage activity. - Source: PubMed
Publication date: 2026/04/06
Pohl FabianSeufert FlorianChung Yin KwanSchick RobinKieslich BjörnSchöneberg TorstenLangenhan TobiasHildebrand Peter WSträter Norbert - Acetylcholinesterase (AChE) is a cholinergic enzyme that hydrolyzes the neurotransmitter acetylcholine (ACh). Dysregulated AChE activity is closely linked to neurodegenerative diseases and cancer. Current chemical probes for AChE detection mostly rely on single-modality fluorescence readouts, limiting their utility. Herein, we developed a set of activity-based multimodal probes, termed , , , and , which combine the complementary strengths of near-infrared fluorescence (NIRF) imaging, photoacoustic (PA) detection, and proteome profiling. These probes offer a comprehensive toolset for deciphering the AChE code in complex biological systems. // enable continuous monitoring of AChE activity via NIRF/PA detection, while represents the first trimodal probe for simultaneous NIRF/PA imaging and proteome profiling in live systems. Notably, the usage of and (1) highlighted the superior capability of PA imaging for deep-tissue studies in live animals, (2) revealed significantly elevated AChE activity in microglia compared to astrocytes in the depressive brain, and (3) identified a functional link between AChE and adhesion G protein-coupled receptor B2 and B3 (ADGRB2 and ADGRB3) in both cellular and murine models of depression. Our study not only provides powerful molecular tools for studying cholinergic systems but also reveals novel therapeutic targets for depression intervention. - Source: PubMed
Publication date: 2026/01/21
Xiang JingWang HaoLi LonghuiYang XuelinXu GuangyuYan JiaqianLi TaoShi ZhengyangXu ChunfaWang RuiTu QidongWang MiaomiaoXie Yusheng