B3GNT7
- Known as:
- B3GNT7
- Catalog number:
- 002360A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- B3GNT7
Related genes to: B3GNT7
- Gene:
- B3GNT7 NIH gene
- Name:
- UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
- Previous symbol:
- -
- Synonyms:
- beta3GnT7
- Chromosome:
- 2q37.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-06-20
- Date modifiied:
- 2016-10-05
Related products to: B3GNT7
Related articles to: B3GNT7
- Keratan sulfate (KS) is a glycosaminoglycan consisting of repeating -acetyllactosamine disaccharides, in which both galactose and -acetylglucosamine are often 6--sulfated. It has been reported that KS recognized by the monoclonal antibodies 5D4 and 373E1 is preferentially expressed in papillary thyroid carcinoma (PTC) and only minimally in other thyroid tumors/lesions or normal thyroid tissue. However, the precise epitopes recognized by these antibodies remain incompletely characterized, and the expression and extent of low-sulfated KS in PTC have not been systematically evaluated. To better understand the nature of KS expressed in PTC, we generated a novel anti-KS monoclonal antibody, 299-1C1, and performed immunohistochemical analyses using 299-1C1 together with two existing anti-KS monoclonal antibodies, 5D4 and R-10G, in combination with keratanase II and endo-β-galactosidase. The results showed that both highly sulfated and low-sulfated KS are preferentially expressed in PTC, including lymph node metastases, accompanied by upregulation of genes encoding key KS biosynthetic enzymes (, , , and ) in integrated TCGA/GTEx transcriptomic datasets. Expression of , , and , but not , was further increased in -mutant PTCs. These findings indicate that anti-KS monoclonal antibodies are useful for the pathological diagnosis of PTC, particularly for distinguishing lymph node metastases from intranodal thyroid inclusions. - Source: PubMed
Publication date: 2026/08/28
Kato EiichiAkama Tomoya OYonemoto NatsumiMuramoto AkifumiFujieda ShigeharuKobayashi Motohiro - Basement membrane-related genes (BMRGs) play a pivotal role in the pathogenesis of several diseases. However, their association with coronary artery disease (CAD) remains unexplored. Therefore, this investigation is designed to elucidate the involvement of BMRGs in CAD mechanisms. - Source: PubMed
Dong ZhaoZhang YuyuLi ZhuangYu HaozhenGe Wei - To investigate a prognostic risk model for thyroid cancer based on immune genes and its link to immune cell infiltration in tumors. - Source: PubMed
Zhang YufanSong ShiliYu XiaochenLi Jie - Mucus covers and protects colonic epithelial cells. Mucus is mainly composed of heavily O-glycosylated proteins called mucins, and disruption of normal mucin glycosylation occurs in ulcerative colitis (UC). Mucin-2 (MUC2) is the major colonic mucin, and MUC2 O-glycans are often extended with sulfated polyLacNAc, also known as keratan sulfate (KS). The GlcNAc residues in KS are added by B3GNT family members. is highly expressed in the colon, and expression is dramatically reduced in UC. However, the function of B3GNT7 in colonic physiology is unexplored. Here we show that B3gnt7 is a key player in colonic physiology through its function in controlling the structure of mucus glycans. We found that B3GNT7 prefers to extend a sulfated acceptor substrate and is required for production of polyLacNAc-modified mucus in a human goblet cell model. , B3GNT7 regulates Muc2, Muc13, and Muc17 O-glycosylation. Intestinal B3GNT7 deficiency increases susceptibility to colitis and enteric infection in mice, showing that B3GNT7-dependent glycosylation confers protective properties to colonic mucus. Taken together, these results demonstrate that B3GNT7 has a function distinct from other B3GNT family members and is critical for maintaining colonic homeostasis. - Source: PubMed
Publication date: 2026/05/19
Burns Mary W NChongsaritsinsuk JoannPropheter Daniel CYin JianyiZuo VivianHuang ChinPeng LanRuhn Kelly AMoremen Kelley WBurstein EzraHooper Lora VMalaker Stacy AKohler Jennifer J - Mucin-2 (MUC2) plays a crucial role in maintaining intestinal homeostasis during acute pancreatitis (AP). We aimed to investigate the role of B3GNT7 (β-1,3-N-acetylglucosamine transferase) in the O-glycosylation of MUC2 in AP. We used two mouse models of AP induced by caerulein/lipopolysaccharide or L-arginine, and observed colonic goblet cells using electron microscopy, noting that Golgi damage was linked to decreased levels of mature MUC2. Golgi stress-associated proteins (reduced GM130 and elevated GOLPH3) were identified using immunofluorescence. Transcriptome analysis revealed the downregulation of B3gnt7, a glycosyltransferase that is highly enriched in the Golgi apparatus of goblet cells in AP mice. B3GNT7 expression was negatively correlated with pancreatic and colonic pathological scores. In patients with AP, intestinal B3GNT7 levels are markedly reduced and correlated with Ranson scores, C-reactive protein levels, and intestinal permeability markers (serum diamine oxidase and D-lactate). Adeno-associated virus (AAV)-mediated knockdown of B3GNT7 reduced O-glycosylated MUC2 levels, exacerbated pancreatic and systemic inflammation, and worsened intestinal permeability and dysbiosis. In vitro, LPS-treated HT-29 cells exhibited Golgi stress (decreased levels of B3GNT7 and O-glycosylated MUC2) that was reversed by L-glutathione (GSH). These findings demonstrate that B3GNT7 downregulation, mediated by Golgi stress, disrupts MUC2 O-glycosylation, exacerbating AP by impairing intestinal homeostasis. - Source: PubMed
Publication date: 2026/05/31
Hu JiaFu YangHuang ZehuaYin NuomingXu BinqiangHuang HuizhenCui MengyanMei QixiangHuang ChunlanZeng YueFan Junjie