B3GALT4
- Known as:
- B3GALT4
- Catalog number:
- 002346A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- B3GALT4
Related genes to: B3GALT4
- Gene:
- B3GALT4 NIH gene
- Name:
- beta-1,3-galactosyltransferase 4
- Previous symbol:
- -
- Synonyms:
- beta3Gal-T4, GalT4
- Chromosome:
- 6p21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-01
- Date modifiied:
- 2017-02-10
Related products to: B3GALT4
Related articles to: B3GALT4
- Centromere-associated genes are linked to genomic instability and tumor progression, yet their significance and immunological roles in osteosarcoma (OS) remain undefined. We developed a centromere-associated prognostic gene model (CPGM) by applying machine learning across independent cohorts, including TARGET-OS and GEO databases. The Meta-OS and GEO datasets were integrated to form a comprehensive Meta-OS cohort for further analysis. Model performance was evaluated using Harrell's concordance index (C-index). Then, the optimal model was selected and validated using Kaplan-Meier plotter, time-dependent ROC (tROC), Cox regression, and nomogram construction. Functional enrichment and immune infiltration analyses were performed to characterize the tumor immune microenvironment. Single-cell RNA sequencing (scRNA-seq) was conducted to assess cellular heterogeneity and intercellular communication. Finally, the function of Beta-1,3-galactosyltransferase 4 (B3GALT4) was validated using in vitro assays to evaluate its effects on OS cell proliferation and migration. The CPGM demonstrated consistent prognostic performance across independent datasets, achieving a maximum C-index at 0.733. The tROC analysis showed strong predictive accuracy, with area under of curve values of 0.857, 0.806, and 0.783 at 1, 3, and 5 years, respectively. Univariate and multivariate Cox analyses confirmed CPGM as an independent prognostic factor ( = 0.002). Meanwhile, high CPGM scores were associated with poor survival, higher tumor purity, reduced immune infiltration, and suppressed antitumor immune responses. Enrichment analyses indicated significant involvement of immune-related pathways. scRNA-seq analysis revealed that high-CPGM cells were enriched in early developmental trajectories and exhibited enhanced intercellular signaling. Among the model genes, B3GALT4 was consistently downregulated in OS tissues and cell lines, and low expression correlated with poor prognosis. Overexpression of B3GALT4 significantly inhibited the proliferation, migration and invasion of OS cells. This study establishes a robust centromere-associated prognostic model linked to immune dysregulation in OS and identifies B3GALT4 as a potential tumor suppressor and therapeutic target. - Source: PubMed
Publication date: 2026/07/14
Yao WenchaoZhang LinPingJiang ZhenBao TaoMa JunhuaNie Jiangbo - Gangliosides play important roles in membrane organization and cellular signaling. Although their involvement in spermatogenesis has been suggested, the specific functions of individual ganglioside species during each stage of germ cell development remain poorly understood. In this study, we generated beta-1,3-galactosyltransferase 4(B3galt4) knockout (KO) mice to investigate the role of B3GALT4-dependent ganglioside in male germ cell development. Immunostaining analyses demonstrated that B3galt4 deficiency caused selective alterations in ganglioside distribution. Although testis size did not differ significantly between KO and control mice, KO males were completely infertile. Histological examination revealed that spermatogenesis in KO mice proceeded to the elongating spermatid stage; however, abnormalities were observed during the late stages of spermatogenesis, including a reduced number of elongating/elongated spermatids and multinucleated giant cells in subsets of seminiferous tubules. Consistent with these observations, the number of sperm recovered from the cauda epididymis was markedly decreased, accompanied by morphological abnormalities and impaired motility. Collectively, these findings demonstrate that B3galt4 deficiency compromises late spermatogenesis and sperm function, resulting in male infertility. Our results further suggest that B3GALT4-dependent gangliosides have stage-dependent roles during late spermatogenesis and sperm development. - Source: PubMed
Publication date: 2026/07/16
Nagata ShinoNishioka SakiIkawa MasahitoOzawa Manabu - Accurate prediction of the lymph node status is essential for clinical decision-making in breast cancer. This work aimed to develop a multimodal deep learning model that integrates gene expression data with hematoxylin and eosin (H&E)-stained whole slide images (WSIs) to predict lymph node metastasis (LNM) and assess the tumor microenvironment in breast cancer. - Source: PubMed
Publication date: 2026/06/20
Sha YongliangZhuang HuijieWang YiqiuGuo HaoCheng Hui - Osteosarcoma (OS) is a malignant primary bone tumor developing from primitive mesenchymal cells. Glycosylation is important in the adhesion, metastasis and transformation of cancer cells. Nevertheless, the investigation of glycosylation-related genes (GRGs) in OS has been infrequently described. - Source: PubMed
Publication date: 2026/03/12
Ding NingLi JinlongShi SongboWang JizuDing YinliangYang Qingshan - Limited information is available on how DNA methylation of cytosine-phosphate-guanine (CpG) sites across the genome regulate circulating von Willebrand Factor (VWF) and factor VIII (FVIII) levels. - Source: PubMed
Publication date: 2026/03/02
Hahn JulieBressler JanFornage MyriamBoerwinkle EricSmith Nicholas LMorrison Alanna Cde Vries Paul S