AXIN1
- Known as:
- AXIN1
- Catalog number:
- 002328A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AXIN1
Related genes to: AXIN1
- Gene:
- AXIN1 NIH gene
- Name:
- axin 1
- Previous symbol:
- -
- Synonyms:
- PPP1R49
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-17
- Date modifiied:
- 2015-08-24
Related products to: AXIN1
Anti-Axin1 produced in rabbit AntibodyAnti-Axin1 (C-terminal region) produced in rabbit AntibodyAnti-Axin1 (C-terminal) produced in rabbit Antibodyanti-AXIN1 (C-Terminus)anti-AXIN1 (C-Terminus)anti-AXIN1 (C-Terminus)Anti-AXUD1(AXIN1 up-regulated) AntibodyAntibodies: AXIN1 HOST: Goat Clonality: pAbAWAT1 Gene acyl-CoA wax alcohol acyltransferase 1Axin1 Primary Antibody, AXIN1, Species: Human Recombinant Protein Source: Rabbit PolyclonalAXIN1 AntibodyAxin1 Polyclonal Antibody, Reactivity: H M R, Gene ID: 8312, Synonyms: AXIN1Axin1 Polyclonal Antibody, Reactivity: H, Gene ID: 8312, Synonyms: AXIN1Axin1 Polyclonal Antibody, Reactivity: H, Gene ID: 8312, Synonyms: AXIN1AXIN1 (Human) Recombinant Protein (Q02) Related articles to: AXIN1
- /Aims: Hepatocellular carcinoma (HCC) is an aggressive disease with limited response to available therapies. Progress in therapeutic development has been hampered by the lack of preclinical models that recapitulate human HCC and support evaluation of multimodal therapies. Here, we employ CRISPR editing to identify alterations that drive hepatocyte transformation and to establish genetically defined HCC models. - Source: PubMed
Publication date: 2026/09/22
Elkhadragy LobnaDavid Olayinka GCastillo Caitlyn CRedlon Luke NJordan Luke RKhan NusratLiu HannahRosa Lopes Isadora AndreZhou YanqiongKanzaki HiroakiHoshida YujinSamuelson Jonathan PLujambio AmaiaSchook Lawrence BGuzman GraceSchachtschneider Kyle MGaba Ron C - is a major human pathogen that can elicit immune-inflammatory responses and infections, largely driven by its broad repertoire of antigenic proteins. Understanding these factors is valuable for elucidating mechanisms of infection. - Source: PubMed
Publication date: 2026/09/02
Dalloul Rajaa S DSohail Muhammad UChennakkandathil SareenaSawarth HinaAl-Noubi MunaChoi SunkyuSchmidt Frank - Water extract of Semiliquidambar cathayensis (WESC) exhibits favorable therapeutic effects against depression, yet its pharmacodynamic material basis and mechanism of action remain unclear. In this study, ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was employed to analyze the chemical constituents of WESC. Network pharmacology and molecular docking were further applied to screen the antidepressant mechanism basis and potential targets of WESC. Lipopolysaccharide (LPS)-induced mouse and PC12 cell models were established as in vivo depressive animal model and in vitro cellular injury model, respectively. Combined with pathological examination and molecular biological techniques, the antidepressant mechanism of WESC was systematically investigated. Results showed that a total of 14 chemical components were identified from WESC. Network pharmacology and molecular docking analyses indicated that GSK3β was one of the key targets, and the active components in WESC possessed strong binding affinities with GSK3β, Axin1, and NF-κB. Pathological studies demonstrated that WESC significantly alleviated inflammatory infiltration in the mouse prefrontal cortex and hippocampal neuronal damage. Molecular biological analyses revealed that WESC markedly downregulated the expression of proteins related to the GSK3β/NF-κB signaling pathway in LPS-stimulated mice and PC12 cells, thereby attenuating neuroinflammation, promoting neural plasticity, and exerting antidepressant effects. - Source: PubMed
Yang LiHe JunhuiLi DongmeiLi YiSu QibiaoLiang HongningYuan JiantongLai KedaoWei Guining - The Ordos fine-wool sheep is a high-quality fine-wool breed in China, renowned for its excellent wool quality, meat production, and adaptability to the arid and semi-arid regions of Inner Mongolia. Body weight and wool traits are important economic characteristics in sheep breeding. This study aimed to identify genetic loci associated with body weight (BW), wool length (WL), and wool fineness (WF) in Ordos fine-wool sheep. - Source: PubMed
Publication date: 2026/08/28
Zhang LifeiGu YingHe XiaolongWang BiaoDa LaiDe DemaTe RigeleLiu YongbinFu Shaoyin - Clutch length is an important reproductive trait in geese, but its epigenetic basis remains poorly characterized. Daily egg production was recorded for 280 individually housed Zi geese, and clutch-related indices were calculated as described in our previous study. Based on these records, six geese with contrasting clutch-length phenotypes were selected and assigned to the long-clutch (LC) and short-clutch (SC) groups. Ovarian tissues from three geese per group were subjected to whole-genome bisulfite sequencing (WGBS) and assay for transposase-accessible chromatin using sequencing (ATAC-seq) to identify candidate epigenetic signatures associated with clutch length. WGBS identified 630,909 differentially methylated regions (DMRs), whereas ATAC-seq identified 902 differentially accessible regions (DARs). Integrated analysis revealed distinct patterns of ovarian DNA methylation and chromatin accessibility between the two groups, suggesting that clutch length variation may be accompanied by epigenomic differences in ovarian tissue. Genes associated with DMRs and/or DARs were enriched in biological processes related to granulosa cell differentiation and endocrine competence, follicular fate regulation, and periovulatory cytoskeletal and signaling remodeling. RERE was prioritized as a candidate locus because it was supported by changes in both DNA methylation and chromatin accessibility, whereas FOXL2, STAR, BAK1, FGF17, PRSS35, ACTR3, and AXIN1 were supported mainly by evidence from a single omics layer. RT-qPCR analysis of selected genes showed expression trends broadly consistent with the corresponding epigenomic differences, providing additional supportive evidence for these candidate associations. Collectively, this study provides an exploratory ovarian epigenomic resource and identifies candidate epigenetic signatures, genes, and biological processes associated with clutch length variation in geese. - Source: PubMed
Publication date: 2026/07/27
Wang HechuanYin JiaxinJiang KeCong KexinLiu YunuoYang WeiranMiao XinyiChen ZhifengZhang YingLiu Shengjun