AURKC
- Known as:
- AURKC
- Catalog number:
- 002314A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AURKC
Related genes to: AURKC
- Gene:
- AURKC NIH gene
- Name:
- aurora kinase C
- Previous symbol:
- STK13
- Synonyms:
- AurC, ARK3
- Chromosome:
- 19q13.43
- Locus Type:
- gene with protein product
- Date approved:
- 1998-05-13
- Date modifiied:
- 2015-08-27
Related products to: AURKC
Related articles to: AURKC
- Macrozoospermia is a rare form of teratozoospermia characterized by tetraploids, large-headed spermatozoa with multiple flagella, usually caused by bi-allelic AURKC mutations. The etiology of atypical phenotypes with a lower proportion of large headed spermatozoa and single flagella however often remains unresolved. - Source: PubMed
Publication date: 2026/09/16
Perrin AuroreMorel FrédéricWehbe ZeinaFrapsauce CynthiaGueganic NadiaTous CorinneCommet SéverineDijols LauraBasinko AudreyDouet-Guilbert NathalieTebbakh CéliaKherraf Zine-EddineRay Pierre FCoutton CharlesMartinez Guillaume - Children with intellectual disability are more likely to experience chronic and neuropathic pain, which remains frequently under-recognized due to limitations in self-reporting and objective assessment tools. Epigenetic mechanisms, particularly DNA methylation, are believed to influence pain perception. This study investigates the differences in methylation patterns between children with intellectual disability and their age- and sex-matched neurotypical controls. - Source: PubMed
Publication date: 2026/05/18
Celsi FulvioZupin LuisaSenn Francescad'Adamo PioCappellani StefaniaDe Zen LuciaCozzi GiorgioSelicorni AngeloBarbi EgidioPeri Francesca - Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by impaired differentiation and accumulation of immature myeloid cells. Aurora kinases and their regulatory genes play key roles in mitotic progression and may contribute to leukemogenesis. This study aimed to evaluate the expression and promoter methylation status of , , and and their regulatory genes, , , and in AML. Peripheral blood samples from 83 AML patients and 28 age- and sex-matched healthy controls were analyzed using MIQE-compliant RT-qPCR for gene expression and MSRE-qPCR for promoter methylation. Diagnostic performance was assessed using receiver operating characteristic (ROC) curve analysis. Expression levels of , , , and were significantly increased in AML patients ( < 0.001), whereas expression was significantly reduced ( = 0.001), and showed no significant difference. Promoter methylation analysis revealed significantly increased methylation in AML ( < 0.001), decreased methylation ( = 0.023), and no significant change in . ROC analysis demonstrated strong diagnostic performance, with showing the highest accuracy (AUC = 0.95), while a combined biomarker panel achieved an AUC of 0.96. Aurora kinase-related genes are dysregulated in AML and may serve as preliminary peripheral biomarker candidates. However, further validation in independent cohorts and more refined cellular models is required before clinical application. - Source: PubMed
Publication date: 2026/04/05
Yalniz Kayim ZubeydeTuncer Seref BugraCelik Demirbas BetulGezer UgurSukruoglu Erdogan OzgeKilic Erciyas SedaDalay NejatSelim Yavuz AkifYasasever Vildan - Decabromodiphenyl ethane (DBDPE), a widely used novel brominated flame retardant, has been increasingly detected across environmental matrices and human samples. Owing to its marked persistence and bioaccumulation potential, DBDPE was designated as a Substance of Very High Concern (SVHC) by the European Chemicals Agency in 2025. However, evidence regarding its potential reproductive hazards remains limited. Here, we systematically investigated the molecular mechanisms underlying DBDPE-induced spermatogenic disorder using an integrated approach that combines network toxicology, machine learning, and in vivo validation. Intersecting 564 DBDPE-associated targets with 1,743 NOA-related differentially expressed genes identified 33 overlapping candidates that may mediate DBDPE-induced spermatogenic disorder. Enrichment analyses implicated the HIF-1 signaling and gap junction pathways in DBDPE-induced spermatogenic disorder. Machine learning prioritized five core genes, including PRKACG, WDR5, AURKC, PFKP, and ASGR1, all of which were downregulated in NOA patients. Molecular docking demonstrated stable binding between DBDPE and these core targets. In vivo, DBDPE exposure disrupted testicular structure, reduced sperm concentration and motility, and decreased expression of the five core proteins, confirming the predicted mechanisms. Additionally, we proposed an adverse outcome pathway (AOP) framework describing key events leading to DBDPE-induced spermatogenic impairment. Collectively, our findings revealed the reproductive toxicity of DBDPE and provided a mechanistic foundation for developing strategies to safeguard male fertility. - Source: PubMed
Publication date: 2026/03/27
Shi WeiSun YuantengLiu KejiaZhang YingLu LuZhou QianPu YuepuSun RongliYin Lihong - Macrozoospermia is a rare cause of male infertility characterized by a high proportion of sperm with large, irregular heads. In this study, we identified a novel homozygous Aurora kinase C () missense variant (c.253G > A (p.Glu85Lys)) in a Chinese infertile man using whole-exome sequencing. Segregation of the c.253G > A variant within the family was confirmed by Sanger sequencing, and In silico prediction tools suggested that the variant is pathogenic. Sperm ultrastructural abnormalities in the patient were further examined using transmission electron microscopy. Our findings identify a novel pathogenic variant associated with macrozoospermia, providing potential value for genetic diagnosis and clinical management. - Source: PubMed
Publication date: 2026/01/13
Zhang JianZhao YijiaDeng LiwenWu YuchunLi RongWang Binbin