ATPBD4
- Known as:
- ATPBD4
- Catalog number:
- 002280A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ATPBD4
Related genes to: ATPBD4
- Gene:
- DPH6 NIH gene
- Name:
- diphthamine biosynthesis 6
- Previous symbol:
- ATPBD4
- Synonyms:
- MGC14798
- Chromosome:
- 15q14
- Locus Type:
- gene with protein product
- Date approved:
- 2005-10-24
- Date modifiied:
- 2014-11-19
- Gene:
- DPH6-DT NIH gene
- Name:
- DPH6 divergent transcript
- Previous symbol:
- ATPBD4-AS1, DPH6-AS1
- Synonyms:
- -
- Chromosome:
- 15q14
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2012-06-30
- Date modifiied:
- 2018-03-22
Related products to: ATPBD4
Related articles to: ATPBD4
- Ferroptosis is a novel form of regulated cell death that involves in cancer progression. However, the role of ferroptosis-related long non-coding RNAs (lncRNAs) in papillary thyroid cancer (PTC) remains to be elucidated. The purpose of this paper was to clarify the prognostic value of ferroptosis-related lncRNAs in PTC. - Source: PubMed
Publication date: 2024/07/05
Zhao Jun YuYao Jin MingZhang Xin ZhongWang Kai LiJiang ShanGuo Si YiSheng Qi QiLiao LinDong Jian Jun - Dedifferentiation is the main concern associated with radioactive iodine (RAI) refractoriness in patients with papillary thyroid cancer (PTC), and the underlying mechanisms of PTC dedifferentiation remain unclear. The present work aimed to identify a useful signature to indicate dedifferentiation and further explore its role in prognosis and susceptibility to chemotherapy drugs. A total of five prognostic-related DR-lncRNAs were selected to establish a prognostic-predicting model, and corresponding risk scores were closely associated with the infiltration of immune cells and immune checkpoint blockade. Moreover, we built an integrated nomogram based on DR-lncRNAs and age that showed a strong ability to predict the 3- and 5-year overall survival. Interestingly, drug sensitivity analysis revealed that the low-risk group was more sensitive to Bendamustine and TAS-6417 than the high-risk group. In addition, knockdown of DR-lncRNAs () strongly promoted cell proliferation, invasion, and migration via PI3K-AKT signal pathway in vitro. Furthermore, downregulation also increased the expression of vimentin and N-cadherin during epithelial-mesenchymal transition. This study firstly confirms that DR-lncRNAs play a vital role in the prognosis and immune cells infiltration in patients with PTC, as well as a predictor of the drugs' chemosensitivity. Based on our results, DR-lncRNAs can serve as a promising prognostic biomarkers and treatment targets. - Source: PubMed
Publication date: 2022/03/07
Wang WenlongBai NingLi Xinying