ATP6V0D1
- Known as:
- ATP6V0D1
- Catalog number:
- 002251A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ATP6V0D1
Related genes to: ATP6V0D1
- Gene:
- ATP6V0D1 NIH gene
- Name:
- ATPase H+ transporting V0 subunit d1
- Previous symbol:
- ATP6D
- Synonyms:
- ATP6DV, VATX, VPATPD, P39, Vma6
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-08
- Date modifiied:
- 2016-10-05
Related products to: ATP6V0D1
32 kDa accessory protein,ATP6D,ATP6V0D1,Bos taurus,Bovine,P39,Vacuolar proton pump subunit d 1,V-ATPase 40 kDa accessory protein,V-ATPase AC39 subunit,V-ATPase subunit d 1,VPATPD,V-type proton ATPase32 kDa accessory protein,ATP6D,ATP6V0D1,Homo sapiens,Human,p39,Vacuolar proton pump subunit d 1,V-ATPase 40 kDa accessory protein,V-ATPase AC39 subunit,V-ATPase subunit d 1,VPATPD,V-type proton ATPaseanti-ATP6V0D1anti-ATP6V0D1anti-ATP6V0D1 (2G12)anti-ATP6V0D1 (3B7)anti-ATP6V0D1 (3B8)anti-ATP6V0D1 (2G12)anti-ATP6V0D1 (2G12) type: Primary antibodies host: Mouseanti-ATP6V0D1 (3B7)anti-ATP6V0D1 (3B8)anti-ATP6V0D1 type: Primary antibodies host: MouseAtp6d,Atp6v0d1,Mouse,Mus musculus,P39,Physophilin,Vacuolar proton pump subunit d 1,V-ATPase 40 kDa accessory protein,V-ATPase AC39 subunit,V-ATPase subunit d 1,V-type proton ATPase subunit d 1ATP6V0B Gene ATPase, H+ transporting, lysosomal 21kDa, V0 subunit bATP6V0D1 antibody Host Rabbit Related articles to: ATP6V0D1
- Autophagy-lysosome dysfunction accompanies dermal fibroblast ageing, yet whether remodelling is transcriptional or post-transcriptional in primary human cells remains unresolved. We reanalysed the Genetic and Epigenetic Signatures of Translational Ageing Laboratory Testing(GESTALT) paired RNA sequencing (RNA-seq) and tandem mass tag (TMT) proteome from 82 donors (aged 22-89) using Data Integration Analysis for Biomarker discovery using Latent cOmponents (DIABLO) for supervised multi-omics integration, weighted gene co-expression network analysis (WGCNA), external Genotype-Tissue Expression(GTEx) transcriptomic comparison, network medicine proximity mapping and CDOCKER molecular docking. Three analyses converged on the autophagy-lysosome axis: Kyoto Encyclopaedia of Genes and Genomes (KEGG) Lysosome ranked first in discordant-quadrant analysis; gene set enrichment analysis (GSEA) identified vacuole organisation and macroautophagy as the top age-upregulated Gene Ontology (GO) terms; and WGCNA recovered KEGG Lysosome in the brown module. Module regression localised most proteomic age signals to the lysosomal degradative-capacity module, whereas the proteasome was unaffected. McNemar testing and GTEx comparison supported a protein-side, post-transcriptional origin. TCIRG1, CTSA and ATP6V0D1 were recurrent hubs. Network proximity computationally prioritised hydroxytyrosol as a lysosomal-degradative-capacity-preferential candidate, and CDOCKER on cathepsin A linked its advantage over tyrosol to an ortho-hydroxyl group forming additional hydrogen bonds. These results support protein-layer-dominant autophagy-lysosome remodelling as a feature of dermal fibroblast ageing and suggest a cell-type-resolved computational route from ageing proteomics to testable dietary candidates. - Source: PubMed
Publication date: 2026/07/29
Cai MengXu Meihong - While acupuncture is an established intervention for insomnia, the neurobiological mechanisms linking its modulation of brain activity to molecular-level changes remain poorly understood. This study addresses a critical gap by integrating multimodal data to uncover how electroacupuncture regulates oscillatory activity in specific brain regions and correlates these changes with proteomic alterations. - Source: PubMed
Publication date: 2026/03/04
Lin LiyuZhao YananYang YueQin ShanWang XiaoqiuWang TingLiu ChengyongWu Wenzhong - In the expansive African region, goats display a diverse array of breeds that have evolved over time to adapt to varying local climates and environments. This study involved the analysis of 1591 samples, including 63 domestic breeds and 164 individuals from wild related species, focusing on genetic diversity, population structure, gene flow, selective signals, and landscape genomics. Our findings revealed lower genetic diversity in wild related species, particularly in the mountain goat (Oreamnos americanus). Gene flow was observed between wild Yura goats and North African populations. Introgression analysis identified 34 adaptive genes from wild relatives, particularly those involved in immune response to environmental stress (RGS family). Selection signatures, based on F, nucleotide diversity (π), and iHS methods, highlighted genes associated with lipid deposition (GSK3B), energy metabolism (HTR4), and response to cold climates (GLIS1). Landscape genomics further identified 23 climate-related genes, encoding integrin complex (ITGAM/ITGAX), sodium channel (SCN7A/SCN9A), and proton transporter (ATP6V0D1), which regulate cell adhesion, ion homeostasis, and pH balance to cope with pathogen pressure in sub-Saharan Africa, osmotic imbalance in arid environments, and heat stress in the East African plateau. This study provides the first systematic explanation of the multi-directional adaptation mechanisms of African goats to high temperature, drought, and pathogen infection. The adaptive gene modules, such as the ABCG1-AGTR1 metabolic axis, provide precise molecular targets for drought stress of livestock in arid regions, and provide a new paradigm for understanding the evolutionary logic of mammalian environmental adaptation. - Source: PubMed
Publication date: 2026/02/12
Peng WeifengWang YihuaZhang YiyuanGao LeiWu LiliWang ShupingGao YiyangShi WanluLu KaixinDeng RongLi JuntingHan JingLu XiaohuiLiu YujieTang XiaojiaoZhang YunxiaLi GuoyinHuang LiYang MingshengLi Xiaoyan - The acidification of the bone microenvironment is recognized as a key contributor to osteoporosis. However, current treatment approaches mainly rely on drugs to inhibit osteoclast activity, which often leads to systemic toxicity. Unlike conventional drug-based interventions, we present a polypeptosome (P) that enables "drug-free" osteoporosis treatment by modulating the bone microenvironment. P was coassembled from poly(ε-caprolactone)--poly(tyrosine)--poly[lysine--(lysine-zoledronic acid)] (PCL--PTyr--P[Lys--(Lys-ZOL)]) and poly(ethylene oxide)--poly(ε-caprolactone) (PEO--PCL) at a mass ratio of 1:1. The zoledronic acid (ZOL) group endows the polypeptosome with efficient bone-targeting capabilities with a hydroxyapatite (HA) binding rate of 75.3%, while the alkaline polylysine and antioxidant tyrosine segments synergistically restore bone microenvironment homeostasis through pH neutralization and ROS scavenging. , P regulates the bone microenvironment by downregulating pH-related genes (including Atp6v0d1) and oxidative stress markers such as lipid peroxidation (LPO) and malondialdehyde (MDA), thus enhancing the bone strength in OVX rats. Transcriptome sequencing further elucidates its therapeutic mechanisms. Overall, P restores bone microenvironment balance by regulating pH and ROS levels, thereby providing both a therapeutic approach for osteoporosis and insights into bone diseases. - Source: PubMed
Publication date: 2025/12/19
Jiang JingjingLiu DanqingZhou XueDu Jianzhong - SARS-CoV-2 non-structural protein 6 (NSP6) in the host's tissue-specific complexities remains a mystery and needs more in-depth attention because of COVID-19 recurrence and long COVID. Its reported role in immune evasion, viral replication and egress from the cells as well as its gain of function mutations occurring independently in various variants underscores its importance. - Source: PubMed
Publication date: 2025/10/22
Chatterjee ShrabontiMahata JoydeepKateriya SuneelAnirudhan Gireesh