ATP6V1E2
- Known as:
- ATP6V1E2
- Catalog number:
- 002235A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ATP6V1E2
Related genes to: ATP6V1E2
- Gene:
- ATP6V1E2 NIH gene
- Name:
- ATPase H+ transporting V1 subunit E2
- Previous symbol:
- ATP6EL2, ATP6V1EL2
- Synonyms:
- MGC9341, VMA4, ATP6E1
- Chromosome:
- 2p21
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-20
- Date modifiied:
- 2016-02-11
Related products to: ATP6V1E2
anti-ATP6V1E2anti-ATP6V1E2anti-ATP6V1E2anti-ATP6V1E2anti-ATP6V1E2 type: Primary antibodies host: Mouseanti-ATP6V1E2 type: Primary antibodies host: RabbitATP6E1,ATP6EL2,ATP6V1E2,ATP6V1EL2,Homo sapiens,Human,Vacuolar proton pump subunit E 2,V-ATPase subunit E 2,V-type proton ATPase subunit E 2Atp6e1,Atp6v1e2,Mouse,Mus musculus,Vacuolar proton pump subunit E 2,V-ATPase subunit E 2,V-type proton ATPase subunit E 2ATP6V1D Gene ATPase, H+ transporting, lysosomal 34kDa, V1 subunit DATP6V1E2 antibody Host rabbitATP6V1E2 antibody Isotype IgG Host RabbitATP6V1E2 (Human) IP-WB Antibody PairATP6V1E2 (Human) Recombinant Protein (P01)ATP6V1E2 (Human) Recombinant Protein (P01)ATP6V1E2 (Human) Recombinant Protein (Q01) Related articles to: ATP6V1E2
- High altitude polycythemia (HAPC) is an important public health problem at high altitude, and genetic factors play a key role in hypoxia adaptation in Tibetan populations. The aim of this study was to investigate the association between and gene locus polymorphisms and genetic susceptibility to HAPC in Chinese Tibetan population. This study included 78 HAPC patients and 85 healthy controls and genotyped the gene single nucleotide polymorphism loci (rs1868092, rs4953396, and rs4953354) and rs896210. We analysed the association between and genes and HAPC using logistic regression analysis Multifactorial dimensionality reduction, protein-protein interaction and KEGG pathway. This study found that rs896210 and rs1868092, rs4953396, rs4953354 were significantly associated with genetic susceptibility to HAPC in the Chinese Tibetan population, and synergistic effects existed among these genetic loci. This provides new evidence for the genetic mechanism of high altitude adapted diseases in Tibetan populations, which is valuable for individualized risk assessment and exploration of potential therapeutic targets for HAPC at high altitude. - Source: PubMed
Publication date: 2026/01/20
Ran LirongLi YongjieLiao DongweiChen ZiyiWang GuangmingZhang Yuanyuan - To identify biomarkers to predict acute liver failure and investigate the mechanisms and immune-related pathways linked to its onset and progression. - Source: PubMed
Publication date: 2024/11/13
Wu XinyanZheng XiaomeiYe Gang - Autophagy, by modulating cellular degradation and recycling processes, affects sperm cell survival and differentiation and may be linked to the pathophysiology of non-obstructive azoospermia (NOA). However, the role of autophagy-related genes (ARGs) in NOA has not yet been fully explored. - Source: PubMed
Publication date: 2025/06/30
Yao JunchengZhang YuanyuanLan TingtingLi Yutao - Homocysteine (Hcy), a sulfur-containing amino acid derived from methionine, has been shown to be a significant and modifiable risk factor for various neurological disorders, including stroke, Parkinson's disease, Alzheimer's disease, and elderly depression. However, there is currently a lack of comprehensive understanding regarding the molecular mechanisms underlying Hcy-induced neurotoxicity. Therefore, this study aimed to establish rat and cell models of Hcy intervention in order to elucidate the underlying mechanism of neurotoxicity. Our research findings demonstrate that Hcy induces depressive - like symptoms in normal Sprague-Dawley rats. Pathological damage and apoptosis were detected in the DG, CA3, and CA1 regions of the hippocampus, along with the cortical area. Moreover, synaptic structural impairment was observed within the hippocampal. Simultaneously, Hcy promotes neuronal apoptosis and LDH leakage in mouse neuroblastoma (N2a) cells. Furthermore, we conducted mRNA microarray analysis to investigate differences in mRNA expressions and utilized Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis for gene function annotations in Hcy-treated N2a cells. The results highlighted significant alterations in 457 mRNAs in the Hcy-treated group compared to the Control group. Among the differentially expressed genes (DEGs), a total of 155 were found to be significantly up-regulated, while the remaining 302 were down-regulated. Furthermore, it was observed that four genes (snap25, cplx1, slc32a1 and atp6v1e2) related to the synaptic vesicle cycle exhibited decreased expression in Hcy-treated N2a cells compared to the Control group. The expression levels of these four genes, as well as their corresponding proteins, were subsequently confirmed using RT-qPCR and western blot analysis, respectively. In conclusion, this study shed light on the detrimental impact of hyperhomocysteinemia on the nervous system, particularly with regard to the synaptic vesicle cycle. - Source: PubMed
Publication date: 2025/05/29
Wang MengLiang XiaoshanJin KeqingLiu YinyueLuo SuhuiZhang QiangWang XuanDong ZhipingZhang Xumei - The effect of electromagnetic exposure on health is becoming increasingly important as it affects many aspects of human life and health. However, the effects in environmental electromagnetic fields on the male reproductive system were still controversial, and the impacts of long-term microwave exposure on testicular tissue remain poorly defined. This study exposed rats to 30 mW/cm of microwave radiation (2.856 GHz) for six weeks and revealed that long-term microwave exposure damaged the testis structures, sperm motility, and morphology, affected hormone levels, energy metabolism, and induced oxidative stress. Assays for bulk RNA, metabonomics, single-cell RNA, and transposase-accessible chromatin with high-throughput sequencing were performed to analyze the transcriptional and metabolic atlas of testicular damage after microwave radiation. Differentially expressed genes were enriched in oxidative stress and energy metabolism pathways. Furthermore, ten subgroups were identified with scRNA-seq, including five developmental phases of germ cells, and radiation-associated changes in cell composition, especially stuck in round spermatids, were observed. Radiation significantly upregulated the expression of Atp6v1e2 in round spermatids and enriched the expression of many transcription factors by disturbing the accessibility profile of chromatin. This study provides effective insights into the long-term impacts of microwave radiation on male reproduction. - Source: PubMed
Publication date: 2025/03/13
Yao BinweiZeng JingShi JingqiPang YueyueMen JunqiLi YanyangWang HeranLiu JingHui WangZhao LiLi ChunlinPeng RuiyunFan Jiao