ATP2B2
- Known as:
- ATP2B2
- Catalog number:
- 002175A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ATP2B2
Related genes to: ATP2B2
- Gene:
- ATP2B2 NIH gene
- Name:
- ATPase plasma membrane Ca2+ transporting 2
- Previous symbol:
- -
- Synonyms:
- PMCA2
- Chromosome:
- 3p25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-26
- Date modifiied:
- 2016-02-10
- Gene:
- ATP2B4 NIH gene
- Name:
- ATPase plasma membrane Ca2+ transporting 4
- Previous symbol:
- ATP2B2, MXRA1
- Synonyms:
- PMCA4
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-10-05
- Date modifiied:
- 2016-02-10
Related products to: ATP2B2
Related articles to: ATP2B2
- Hsa-miR-99a has been linked to the advancement of several malignancies, including colorectal cancer (CRC). This investigation seeks to elucidate its function and regulatory network in CRC. - Source: PubMed
Publication date: 2026/03/17
Yang XuejingZhang TingtingSun HuFeng HuijingSong Dong - Remodeling of Ca signaling is an important step in cancer progression, and altered expression of members of the Ca signaling toolkit including the plasma membrane Ca ATPases (PMCA proteins encoded by ATP2B genes) is common in tumors. - Source: PubMed
Publication date: 2018/10/23
Varga KarolinaHollósi AnnaPászty KatalinHegedűs LucaSzakács GergelyTímár JózsefPapp BélaEnyedi ÁgnesPadányi Rita - The P-type ATPases family consists of ion and lipid transporters. Their unique diversity in function and expression is critical for normal development. In this study we investigated human pluripotent stem cells (hPSC) and different neural progenitor states to characterize the expression of the plasma membrane calcium ATPases (PMCAs) during human neural development and in mature mesencephalic dopaminergic (mesDA) neurons. Our RNA sequencing data identified a dynamic change in ATPase expression correlating with the differentiation time of the neural progenitors, which was independent of the neuronal progenitor type. Expression of ATP2B1 and ATP2B4 were the most abundantly expressed, in accordance with their main role in Ca regulation and we observed all of the PMCAs to have a subcellular punctate localization. Interestingly in hPSCs ATP2B1 and ATP2B3 were highly expressed in a cell cycle specific manner and ATP2B2 and ATP2B4 were highly expressed in a hPSC sub-population. In neural rosettes a strong apical PMCA expression was identified in the luminal region. Lastly, we confirmed all PMCAs to be expressed in mesDA neurons, however at varying levels. Our results reveal that PMCA expression dynamically changes during stem cell differentiation and highlights the diverging needs of cell populations to regulate and properly integrate Ca changes, which can ultimately correspond to changes in specific stem cell transcription states. - Source: PubMed
Publication date: 2018/02/06
Chen MuwanLaursen Sofie HHabekost MetteKnudsen Camilla HBuchholdt Susanne HHuang JinrongXu FengpingLiu XinBolund LarsLuo YonglunNissen PoulFebbraro FabiaDenham Mark - Along with sodium/calcium (Ca) exchangers, plasma membrane Ca ATPases (ATP2Bs) are main regulators of intracellular Ca levels. There are four ATP2B paralogs encoded by four different genes. Atp2b2 encodes the protein pump with the fastest activation, ATP2B2. In mice, the Atp2b2 transcript has several alternate transcriptional start site variants: α, β, µ and δ. These variants are expressed in developmental and tissue specific manners. The α and β Atp2b2 transcripts are equally expressed in the brain. αAtp2b2 is the only transcript found in the outer hair cells of young mice (Silverstein RS, Tempel BL. in Neuroscience 141:245-257, 2006). Mutations in the coding region of the mouse Atp2b2 gene indicate a narrow window for tolerated dysfunction of the ATP2B2 protein, specifically in the auditory system. This highlights the necessity of tight regulation of this gene for normal cell physiology. - Source: PubMed
Publication date: 2017/05/22
Minich Rebecca RLi JinTempel Bruce L - The bulk of human genes undergo alternative splicing (AS) upon response to physiological stimuli. AS is a great source of protein diversity and biological processes and is associated with the development of many diseases. Pheochromocytoma is a neuroendocrine tumor, characterized by an excessive Ca2+-dependent secretion of catecholamines. This underlines the importance of balanced control of calcium transport via regulation of gene expression pattern, including different calcium transport systems, such as plasma membrane Ca2+-ATPases (PMCAs), abundantly expressed in pheochromocytoma chromaffin cells (PC12 cells). PMCAs are encoded by four genes (Atp2b1, Atp2b2, Atp2b3, Atp2b4), whose transcript products undergo alternative splicing giving almost 30 variants. - Source: PubMed
Publication date: 2014/06/06
Kosiorek MichalinaPodszywalow-Bartnicka PaulinaZylinska LudmilaPikula Slawomir