ATP2A2
- Known as:
- ATP2A2
- Catalog number:
- 002172A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ATP2A2
Related genes to: ATP2A2
- Gene:
- ATP2A2 NIH gene
- Name:
- ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
- Previous symbol:
- ATP2B, DAR
- Synonyms:
- SERCA2
- Chromosome:
- 12q24.11
- Locus Type:
- gene with protein product
- Date approved:
- 1990-09-10
- Date modifiied:
- 2016-02-10
Related products to: ATP2A2
Related articles to: ATP2A2
- Copper oxide nanoparticles (CuONPs) are widely employed in industrial and biomedical applications; however, their long-term exposure induces severe cardiac impairments. Spiraeoside (SPD) is a naturally occurring flavonoid with diverse biological properties. The current study was designed to investigate the cardioprotective effects of SPD against CuONPs-induced cardiotoxicity. Thirty-two rats were randomly allocated into four groups: control, CuONPs (100 mg/ kg), CuONPs (100 mg/kg) + SPD (200 mg/ kg), and SPD (200 mg/kg) alone treated group. Our findings showed that CuONPs exposure substantially reduced the expression of ATP2A2, RYR2, CACNA1C, and GSK3B while upregulating CAMK2D, AXIN2, WNT3A, and CTNNB1. Moreover, CuONPs intoxication induced severe oxidative imbalance as evidenced by high levels of ROS and MDA while reducing the activities of GST, GSR, CAT, HO-1, SOD and GPx. Besides, CuONPs administration increased the levels of Troponin-I, LDH, Troponin-T, CRP, BNP, NT-proBNP, CPK, and CK-MB. Severe echocardiographic alterations were found after CuONPs exposure as indicated by significant reduction in heart rate, high EDV and ESV, as well as ventricular dilation. Similarly, CuONPs induced marked upregulation of pro-inflammatory markers including COX-2, IL-6, IL-1β and TNF-α. A significant upregulation of Bax, Caspase-3, and Caspase-9 while a marked reduction in the levels of Bcl-2 was found following the exposure of CuONPs. Histopathological analysis showed severe structural myocardial damage in response to CuONPs intoxication. Nonetheless, SPD notably protected cardiac tissues via regulating calcium-dependent signaling pathways, inflammatory and apoptotic responses, echocardiographic parameters, oxidative stress, and histopathological alterations. Collectively, these findings suggest that SPD is a promising natural bioactive molecule against cardiac injury caused by nanoparticles. All preclinical studies, such as pharmacokinetic, toxicological, and dose optimization investigation, are still needed to assess the potential clinical applicability. - Source: PubMed
Publication date: 2026/08/28
Arshad RameeshaMehreen ArifaJamil SalimHassan Hesham MHalawani Ibrahim FAlsharif Khalaf FAlzahrani Khalid J - Anthracycline-induced cardiotoxicity remains a major limitation in cancer therapy, with substantial inter-individual variability in susceptibility, including documented sex differences. However, the molecular basis underlying these disparities remains incompletely understood. In this study, we employed large-scale data-independent acquisition proteomics in a long-latency rat model of doxorubicin-induced cardiomyopathy to characterize early cardiac proteomic remodeling. Longitudinal echocardiography demonstrated a significantly greater decline in fractional shortening in males compared to females. Early proteomic profiling identified 5184 proteins and revealed widespread remodeling across metabolic, mitochondrial, cytoskeletal, and stress-response pathways. While doxorubicin induced broad proteomic changes in both sexes, two-way limma-based sex-stratified analyses identified 430 proteins exhibiting significant sex-by-treatment interactions. Our results suggested that doxorubicin was associated with alterations in oxidative phosphorylation, fatty acid metabolism, and calcium handling pathways. A female-specific upregulation of mitochondrial proteins, including Sco1, Cox17, and Atp2a2, which may be associated with preserved energetics and Ca handling, was detected. In contrast, male hearts demonstrated reduced Micu1 and RyR2 together with increased levels of Ppp1ca, findings that may indicate alterations in mitochondrial function and, excitation-contraction coupling. We also observed lower levels of calcineurin (Ppp3cb) in females. Baseline proteomic differences between sexes further implied distinct regulatory states that may shape the cardiac response to doxorubicin.Together, these findings suggest early proteomic remodeling upon doxorubicin treatment and represent candidate molecular targets that warrant functional validation in future studies. This work offers hypothesis-generating mechanistic insights into sex-specific responses to anthracycline-induced cardiomyopathy and underscores the importance of incorporating sex as a biological variable in cardio-oncology research. - Source: PubMed
Publication date: 2026/08/15
Sedighi SogolChen LijunWang YuefenLebarbenchon KauiYi JenaMenghani TanviShah Firasat AliYang SamSaeki HarumiIto TomoakiOrita HajimeZhang HuiO'Rourke BrianFoster D BrianGabrielson Kathleen L - The 5' mRNA leader regulates translation through its length and upstream open reading frames (uORFs), but its systematic remodeling in cancer remains unclear. We analyzed isoform-weighted 5' leader features across The Cancer Genome Atlas, the Genotype-Tissue Expression transcriptomes and the Clinical Proteomic Tumor Analysis Consortium proteogenomic cohorts. Tumor-associated shifts frequently opposed normal tissue aging trajectories, with the clearest signals in lung adenocarcinoma and lung squamous cell carcinoma. Raw closed-uORF burden defined the sharpest paired-supported lung cores, whereas residualized closed-uORF burden provided the most stable length-independent signal. Colon adenocarcinoma reproduced the transcriptomic pattern but showed a prominent adjacent-normal field effect, with nontumor colon already shifted toward the tumor pattern relative to healthy colon. Upstream-initiation features did not improve proteome-wide prediction beyond mRNA abundance but showed modest, gene-selective associations within independently prioritized age-opposed lung gene sets. Recurrent proteogenomic anchors included and . These findings define an age-opposed, tissue-dependent pattern of 5' leader remodeling and prioritize specific genes and isoforms for functional investigation. - Source: PubMed
Publication date: 2026/08/18
Pal AyonPal RanavRoy VivekChaki Madhumita GRoy Bhaskar - To report a rare case of refractory generalized Darier's disease (DD), also known as keratosis follicularis, with a disease duration exceeding 40 years and to explore the therapeutic effect of the interleukin-17A inhibitor secukinumab. - Source: PubMed
Publication date: 2026/08/13
Ou YangfeiFang HuiLiu TingtingCai ZongkunCheng Li - Congenital pathogenic gene variants may not elicit symptoms until later in life, highlighting the importance of identifying extra-genetic factors influencing the onset and severity of heritable diseases. We explored this in Darier disease (DD or -nEDD), an autosomal dominant skin disorder arising from heterozygous variants leading to haploinsufficiency of the endoplasmic reticulum (ER) calcium pump, SERCA2. Metabolic analysis of epidermal keratinocytes from confirmed patients with DD revealed abnormalities in the pentose phosphate pathway responsible for regenerating antioxidants like glutathione, accompanied by diminished free glutathione and increased glutathione-based, oxidative modifications of SERCA2. Induction of oxidative stress weakened intercellular adhesion, a defining characteristic of DD, which antioxidant treatment improved. Treatment with antioxidants or SERCA activators also diminished glutathionylation, consistent with SERCA2 haploinsufficiency giving rise to oxidative stress and placing residual SERCA2 at risk of oxidation. We posit that partial loss of protein activity primes cells for stress-induced loss of the remaining activity, a mechanism that may drive disease flares in other haploinsufficiencies. - Source: PubMed
Publication date: 2026/08/05
Harmon Robert MMcCarthy Erin FKrol AnnetteShetti AashutoshBraun JonasDiDominicis Rosemary JGodsel LisaRen ZiyouPerez White Bethany ECohen-Barak EranDodiuk-Gad RoniGudjonsson Johann EPaller Amy SSimpson Cory LWeinberg SamuelDahl RussellGoyal YogeshPrakriya MuraliGreen Kathleen J